ID A0A0N1NHY6_9ACTN Unreviewed; 748 AA.
AC A0A0N1NHY6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=MMPL domain protein {ECO:0000313|EMBL:KPI13115.1};
GN ORFNames=OK074_8843 {ECO:0000313|EMBL:KPI13115.1};
OS Actinobacteria bacterium OK074.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592327 {ECO:0000313|EMBL:KPI13115.1, ECO:0000313|Proteomes:UP000037991};
RN [1] {ECO:0000313|EMBL:KPI13115.1, ECO:0000313|Proteomes:UP000037991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK074 {ECO:0000313|EMBL:KPI13115.1,
RC ECO:0000313|Proteomes:UP000037991};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI13115.1}.
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DR EMBL; LJCV01000151; KPI13115.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1NHY6; -.
DR PATRIC; fig|1592327.3.peg.4156; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000037991; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037991};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..329
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 727..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 77116 MW; 82297BD45FB1AA81 CRC64;
MATVLYHLGR VSFRWRWLVT FLWIAVLGAV GFAAAKAPTA PDDGFTMPGI ESQKAFDLME
QRFPGAAADG ASARIVFVAP NGEKVTAAEN KKVIETLVGS AADGAQVSNA VDPFQAKAVS
KDGTVAYSTV NFKVKADDLS DGAKKHLESA IEVARHAGLT VEVGGDALAT KPAAGGSAEA
IGIAIAAVVL LITFGSLAAA GLPLLTAVLG VGISMSAILA LGTTFGLSET TGTLATMLGL
ACGIDYALFV VSRYREERAK GRTPQEAAGM AAGTAGSAVV FAGLTVVIAL AGLTVVGIPL
LTKMGLAAAG AVLVAVLISL TLVPAILGFW PNKVLSRGVR RNTKRSRKGT ENNGGSRWAR
FVTRRPLPVL LLSVVGLGAV AVPMLGLQLG MPGDEAKPTS TTERRAYDDL AKGFGPGFNG
PLTIVVDAKG TANAKTAVAT IEKKIAATDG IVSVSTATFN QAGDTAIFSA TPSTAPTDKK
TEDLVTKIRD ERPATESATG ASFEVTGTTA LNIDVAKKVQ GALIPYLIVV VGLAIVLLLL
VFRSLLVPLK AALGFLLSVL AALGAVVFVF QEGHGASLLG VETSGPIMSM MPIFLVGIVF
GLAMDYEVFL VSRMREAYVH GEGAKPSIVS GFRHSARVVV AAALIMMAVF SGFIGAGESM
IKMIGFGLAI AVFFDAFVVR MAIVPAILAL LGDKAWYLPR WLDRVLPNID VEGEALTRKH
EVAAAAASAS ADRDGDGASA GVELTSVK
//
