ID A0A0N1PFB3_LEPSE Unreviewed; 2136 AA.
AC A0A0N1PFB3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Putative RNA helicase {ECO:0000313|EMBL:KPI90208.1};
GN ORFNames=ABL78_0726 {ECO:0000313|EMBL:KPI90208.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI90208.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI90208.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI90208.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI90208.1}.
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DR EMBL; LJSK01000009; KPI90208.1; -; Genomic_DNA.
DR EnsemblProtists; KPI90208; KPI90208; ABL78_0726.
DR VEuPathDB; TriTrypDB:Lsey_0009_0570; -.
DR OMA; MCSATEF; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:UniProt.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KPI90208.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 447..629
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 667..868
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1316..1490
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1521..1732
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2136 AA; 239790 MW; CF4E3FF171777B5E CRC64;
MQSTGPSDPG PGGNGQEKVN LNANAAPYQG KFSGRGRGGN NRIYCSPTNN NSSSANDAER
DSATQGAGMT SGSPEFKAPD VQAANAGSFY GNEKAASASR AQLGNRGRRN RGGAGSSDAA
SVGTSAAVTA AMSRLQSLLA ASQRSSAKQG LSDPQGSGLH CSLAEDMFSG GASASSFVTE
CMQTQRPVAL LTHSGEPLSP RGDRVGGAGR SAYQLQRKVP LDMLLSSVDD IVSQVYVNFD
EDLTKVLLNA LDRVTACDTA DQRERAKVRV IDEMLEVLGD KHYDLLQCIM YRPREVFLRL
LEEFCTLDDD GDTGASQSSG GPQGLTVRFV KNAAQRSQAQ DVVIGSTGKI TDQKWLSQMN
KRYRILMQES DLDALFKRDF SVTGSIMPAG ATVTKKPGHV RIHIPPPRQE IMPAEKRVCV
ATSLPEWTHP AFLSITHLNT IQTTIFQTAF HTSQNMLVCA PTGAGKTVCA LLVMLRCISE
HFDDGILDRD FKIIFVAPMK ALAQEMVENF SRRLAPFMMK VRELTGDMQL TKRELAETQV
IVTTPEKWDV ITRKSSNEEL ISQVRLIIMD EIHLLNEERG PVLEAIVART LRHGELNPEL
RVRLVGLSAT LPNYKDVANF LQADLREGLK VFGPEYRPVP LEQTFIGVQS SGSQQKHNKE
YELDRLAYEE VVRNMREGHQ VMVFVHSRKQ TVQLAKYFVE EAKRRGEEHL FQFKGVMPPA
IEKKGRTLQG RDLSALFASG FGAHHAGLIR YDRTSTEGFF RDGYLRVLCC TSTLAWGVNL
PAHTVVIRGT QMYDPKRGGL VSISVLDVMQ IFGRAGRPQF DTSGHGIIIS DDKEVSHFLR
LIAHALPIES QMQGKLCDHL NAEVNAGTVS SVMEASSWLE YTYMWQRIRV NPLTYGLKVN
NVRKDPELKM VRYEMINTSF TDLAIAGMVR YNPETGSVES TDLGRLASHY YITYESISIF
NEKMRRPDDT WIDSLDMGTA MNIAASAKEF SQLKVRQEEL DELQKLHQML PKQVREYRVS
GESTDETSTQ WKVTTLLKAY ISRLAVEAHS LSSDMVYVLQ NMPRICRALF EIELERGHPL
TTYTYLTLCK CMEHRCWDFE HPLMQFANWG RRVNITDAVW VNLNKRNPSM QLLQEMSAKE
VGQMVHNVRV GRDIADLVAK FPSVNIDIDV QPITRSILRV KVTIVADFAW SRDISGNSEL
FWLLVEDQDN HFIFHHESVM ITRKEVEAGI PHVVNLAVPI VPQYDMYSVR LYSDRWMGCK
EDYTFSIGHL HLPEDSQMTT KLLPLSPLRL HVIPEEYHVL YKRYNQFNAV QTQIFHAMFH
TDQNVFLGAP TGSGKTIAAE MAVLRVFERY PGKKVVYIAP LKALVKERLR DWRTRMRLIG
RSVVELSGDA TPDISALAKA DILCTTPEKW DGISRNWQVR SYVTAVKLVV FDEVHMLGTD
RGPILEVIVS RMRYIGWNLK APIRLVGLST AVSNPGDLGS WLGVEKKWAI FNFDPSVRPV
PMTVHISGYH GKNYCPRMAT MNKPTYNAIC EKSPTQPVIV FVSSRRQTRL TAMALIGFLL
MEGNTAKWVH MDVGQVQKYT SQLDDPYVKH CLQFGVGIHH AGLLEGDRTI VEDAFLSGRI
QVLVATSTLA WGVNFPAHMV VVKGTEYYDA KTSSYVDFPI TDVLQMIGRA GRPQYDTEGV
AQVLCHEPKK GFYRKFLYDP FPVESALHRQ LHVHINAEIV SGTINTRQDA VNYLTWTYLF
RRIARNPSYY GLEDGSPKAV TIFLSSLVKN VLADLERCGC IEPPEAMDDD ADPDAIQYTV
LGKLCSYYYI SHLTVDLFNR SIEPDQTCAE LLRLLCDAEE FNELPVRHNE DKLNMELARQ
LPLPIRDAES DSPHAKAYLL FQALFDRAPM PITDYLTDQK SAMDNAVRVI QAMTDVAANN
GHLYAALRCM TLMQCMVQAR WWDDNSLMQI PNVVKAMLPV IEKECGVRHA AELANSPLSV
LQQFQRVLEM PVFGLQKRDV NESMEAVRGL PLIQVDLTVA QQPTQPEDED AGATYELGVH
LQRLSFGQNS VVAPHFSKTK DEQYWVVVGH EPTGELVALK RVNRLRQSHT AVLRIDWDED
WVQYSSDGTV ELNVYLVCDS YIGMDQQYSF TLPKPC
//
