ID A0A0N4TI35_BRUPA Unreviewed; 429 AA.
AC A0A0N4TI35;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=L-lactate dehydrogenase {ECO:0000256|ARBA:ARBA00012967};
DE EC=1.1.1.27 {ECO:0000256|ARBA:ARBA00012967};
GN ORFNames=BPAG_LOCUS7837 {ECO:0000313|EMBL:VDN89023.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000787501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000787501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN89023.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate
CC from pyruvate: step 1/1. {ECO:0000256|ARBA:ARBA00004843}.
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
CC {ECO:0000256|ARBA:ARBA00006054}.
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DR EMBL; UZAD01013129; VDN89023.1; -; Genomic_DNA.
DR STRING; 6280.A0A0N4TI35; -.
DR WBParaSite; BPAG_0000787501-mRNA-1; BPAG_0000787501-mRNA-1; BPAG_0000787501.
DR UniPathway; UPA00554; UER00611.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004459; F:L-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd05293; LDH_1; 1.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR018177; L-lactate_DH_AS.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR PANTHER; PTHR43128:SF16; L-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02866; Ldh_1_C; 2.
DR Pfam; PF00056; Ldh_1_N; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR PROSITE; PS00064; L_LDH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..198
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 201..253
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT DOMAIN 296..383
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
SQ SEQUENCE 429 AA; 47175 MW; AF3A1301274225B0 CRC64;
MCRYKTGSYF RMSETTAALF KEIVPAHRTP HSKVTVVGVG QVGMACAVSI MQKIVVTSDF
RFTILHCTFE VNFTYLKGLQ NIVSELCLVD VVADKLKGEM MDLQHGVPFM NPCIIRASVD
YEITKGSKLC VVTAGVRQRE GESRLSLVQR NVEIFKGIIP KLVANSPDAM LLIVSNPVDV
LTYVAWKISG LPPHRVFGSG TNLDSARFRF LLSEKLGIAA TSCHGWIIGE HGDSSVPVWS
GVNVAGVALR DVKPDIGKSA DSDKWQEEVH KGVVSAHVLI SLLYFSFCIF QFPGIAYEII
KLKGYTSWAI GMSTAAIASI ALRNTRSVCA LSVNVKGLHG INQDVYLSLP VVLGENGITH
IVKQNLNETE IKQLQKSAAQ LYEVQCGIKE FKGFVLHSIF TKHVMCVQIS AEENGLKSKI
RQWLVAYVP
//
