ID   A0A0N4TRY3_BRUPA        Unreviewed;       940 AA.
AC   A0A0N4TRY3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=DNA_MISMATCH_REPAIR_2 domain-containing protein {ECO:0000313|WBParaSite:BPAG_0001143401-mRNA-1};
GN   ORFNames=BPAG_LOCUS11396 {ECO:0000313|EMBL:VDN92582.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001143401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001143401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN92582.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271}.
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DR   EMBL; UZAD01013228; VDN92582.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4TRY3; -.
DR   STRING; 6280.A0A0N4TRY3; -.
DR   WBParaSite; BPAG_0001143401-mRNA-1; BPAG_0001143401-mRNA-1; BPAG_0001143401.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0007127; P:meiosis I; IEA:UniProt.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 1.10.1420.10; -; 1.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 2.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627}.
FT   DOMAIN          668..684
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   REGION          101..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..128
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   940 AA;  106900 MW;  A68FE4EF8D96C092 CRC64;
     MSARILSVYY NRNRLGAACY DQETATIFVL TDLLEDEDDF RMAHSLLLQL EPSIVIVSKM
     QDVNLLTKLN KLYCYEKCFF VFVYLFLIGF GEKNSTATKI PDKKTEQNSA INEEEMDEKD
     EEDVDENEEQ IEERPLIALH LMPSVAYNFE DAKKRISSLF ESLNLTEEEN HLRLAFRVDL
     TATNMISAFG ALLKYLDAVR LGVEFEDINT KTPISTIKTI TLEEMLQMDD SSMRALQIFQ
     DDLHPSACKA YSVGGAREGI SLFRMCNRCQ SKSGEALLRR WFERPTTNRE TLTNRVTAIH
     YFVQDCNLDS ADFIRIRLKK ICILKGILKR AKSQRLSVND WRNLYMTCNT AQQIMDYIKM
     REIKLKLFEN DIRMIGSDIT RITAVIFEVI NFSESFVENR FVVNANVDGN LDQLKKLYAS
     LPETLTHIAR MEAVALNVPS AVCYVPMFGY LLVVPKNTVF PLSVQNEIEL LYEIEDALHV
     KNDRMRELDR EIGDIKMEII DIETNAMLKL KQLICRYDKA IRQAINVCAK LDCIISLALT
     AREYNWYCPR YVDESIIDVD DGRHAIMELL SKTKFVPNPI RSGGAQTKVK ILMGPNTSGK
     SIYLKQIGII VFLAHIGSFV PAKSATIGPV DRIITRMHSL DCVLDGMSTF ANDLSQMAIA
     LRRGTGNSLI LIDEFGKGTV MEAGLSLLTS SLNYWIRKGK TDCPHVFAVS HFHSLIDHIV
     KDVNLLSFLT MDVILNDGNF DFQYKLVDGF IDFSHASYVA SKVGIGDEVI KRANQIYECL
     KCNKPIDPLD DDDGELLFKI VPLLDNLKNT DFNVDLKNFL QIMTDLLLPV QEQNATLMEE
     MNENVDMNIQ NDDSINVEQI DLTRSDDQRI KLGQNDSHAS SSEVLQRLND SAIILTDLLH
     GPEDNNSTMI DIFESCLNAT GKSSIMKKTQ FEHASFNLFN
//