ID   A0A0N4UEI6_DRAME        Unreviewed;       830 AA.
AC   A0A0N4UEI6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000579301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000579301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC       {ECO:0000256|ARBA:ARBA00008695}.
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DR   AlphaFoldDB; A0A0N4UEI6; -.
DR   WBParaSite; DME_0000579301-mRNA-1; DME_0000579301-mRNA-1; DME_0000579301.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000038040; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd16023; GPI_EPT_3; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   InterPro; IPR037675; PIG-O_N.
DR   InterPro; IPR039524; PIGO/GPI13.
DR   PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR   PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..830
FT                   /note="GPI ethanolamine phosphate transferase 3"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005886710"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        521..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        572..589
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        639..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        679..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        710..728
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        740..762
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        768..787
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        807..826
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   830 AA;  95518 MW;  21EC5A0BAD9E1268 CRC64;
     LTLSLTVSLL MFQYGILIKR VELNERSSCS DVSYSINSCW VPSQFNRIIL IIVDALRYDF
     VNPTNSHTFY GGHMKNVNNL LSRNNGNSLL FHFIADPPTT TMQRLKALTT GSLPTFIDMN
     SNFASASISE DNWIDQLVQS GRKIVFMGDD TWVSLFPKQF HRKYHLPSFD VYDLHTVDDM
     ILGNIYNELR RSDWTVLIAH FLGVDHCGHK HGPKSPEMVA KLSQMDDFIK NMTDLMNDET
     LLVVMGDHGM TETGDHGGDA DMEIDAALFL YSRKKLLHSQ FVSDSVSQVD IVPTLSLLLD
     LPIPFSNIGI VIESIFPQKL LPLVLRSNTW QIIRYAQRMA SEIPELEWHL RQFESGTENL
     RKYRDTMSRM QLVFRYFWTS FNSYFIMIGL LSLLEAVLNC ADSIFNGDDI SISWLIFRSG
     LLFMQAATYI TGDEEHYFSV IFILLCSSVS FRIIYLLNSL LTVTYSWSTV MLLFFLFFHA
     ISFFSNSFIV FESITIRFLT QQKFNRPRRF MSFLDWFKHR LEYRKILMVL LVLFLLRLGS
     VFERCREEQQ SACIQTVFAE PLSKVPSDTL KIIRFITAIL SFSFANYFAY QYLQKFPSES
     VHSSFLFPSA IATICHWSTE LIPDKVLNHF PAFSHITAQV VYVISLCGML AICVRLIRKG
     PFRLFEGCSY SYMLCISEIL ALILGDGLAL SLTIVLSVLF ISLRFIDNEY HLVLFLTLFS
     SHSFFALAHQ STFTSIPWNA AFVGIPGNFI YHWIPATLII MHVFASQILY SFSLPLFVFS
     IICATALHRR HLMMWKVFAP KFIFESLSLC IINITVVLTC CIFRNISFIK
//