ID A0A0N4UG21_DRAME Unreviewed; 447 AA.
AC A0A0N4UG21;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE RecName: Full=Tubulin gamma chain {ECO:0000256|RuleBase:RU000352};
GN ORFNames=DME_LOCUS9526 {ECO:0000313|EMBL:VDN59553.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000641501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000641501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN59553.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Tubulin is the major constituent of microtubules. The gamma
CC chain is found at microtubule organizing centers (MTOC) such as the
CC spindle poles or the centrosome. {ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; UYYG01001184; VDN59553.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4UG21; -.
DR STRING; 318479.A0A0N4UG21; -.
DR WBParaSite; DME_0000641501-mRNA-1; DME_0000641501-mRNA-1; DME_0000641501.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0000930; C:gamma-tubulin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR CDD; cd02188; gamma_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002454; Gamma_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF7; TUBULIN GAMMA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01164; GAMMATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT DOMAIN 48..251
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
SQ SEQUENCE 447 AA; 49496 MW; 3A8369C8A274D6D2 CRC64;
MPNELITVQF GQCGNQIGDA FWRSLCAEHG IAPNGTLIKP ELDAQDLKRV FFYQADDAHY
VPRAVLVDLE PRVINSIINS EYRSFYNAEN IFQSKSGGGA GNNWASGYIQ GREAQEALFD
MLEREAENSD YLEGFMLCHS IAGGTGSGMG SFTLEKISDR FPKKLVQTYS VFPVIRKGEA
SDVVVQPYNS ILTLARLIDH PNCVVVLDNT ALHRIATENA PNSISASSFA LINSLVSRIM
CASTATIRFP GAMNTRLINL IAPLVAYPPM RFIQTGFTPL RDGEACVTKT SVGDVLRRLL
QPKSMMSSAT MEDDVEHCVL SAIAILQGRI DPSEIYVSLG KIKEKNQIKF APWGSGSLNI
TQCRLSPYLP LTNRVSGLML CNHTNTASLF QESLTHCETL FKKKAYLEQF LKEDPDILQT
LGDSVECVRE MIDTYRSATK ANFIDFE
//
