ID   A0A0N4UI19_DRAME        Unreviewed;      1140 AA.
AC   A0A0N4UI19;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=B30.2/SPRY domain-containing protein {ECO:0000313|WBParaSite:DME_0000723201-mRNA-1};
GN   ORFNames=DME_LOCUS9900 {ECO:0000313|EMBL:VDN59927.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000723201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000723201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN59927.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004326}.
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DR   EMBL; UYYG01001195; VDN59927.1; -; Genomic_DNA.
DR   STRING; 318479.A0A0N4UI19; -.
DR   WBParaSite; DME_0000723201-mRNA-1; DME_0000723201-mRNA-1; DME_0000723201.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   Gene3D; 1.10.490.160; -; 1.
DR   Gene3D; 2.60.120.920; -; 2.
DR   Gene3D; 2.80.10.50; -; 2.
DR   Gene3D; 6.20.350.10; -; 1.
DR   Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46399:SF8; RYANODINE RECEPTOR 44F-LIKE PROTEIN; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR   SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR   SUPFAM; SSF82109; MIR domain; 2.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50919; MIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT   DOMAIN          106..160
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          584..805
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
SQ   SEQUENCE   1140 AA;  128832 MW;  2802F0F6127C6BE7 CRC64;
     MTDKEEGGNG EQDDISFLRT GDIVAMTCMA SANREGVLGS ERVCLCTEGF GNRMCILESV
     SDRDIPPDMS MCMLYIDNAL SMRALQEMMS SGSANELKGA GGGGGHKTLL YGHAVQLKHV
     LSEMYLACLS SCSSNDKLAF DVGVQEKNDD EACWWIIHPA SKQRSEGEKV RVGDDVILVS
     VATERYLHMA HNKGYMVIAS FHQTLWNITS VSSGSIRVRN IGHLFGSDVV RFFHGNDEVL
     TIPENWSEYP QHNMVIYEGG SAVSQARSLW RIELIRMKWH GALINWEHAF RVRHITSGRY
     LGVLENAVQL YHKDKSDYDL TAFIMCQNKD QKKQMLEEKE EEGMGIATIR YGETDAFIQH
     IKTQLWLSYQ TSEVTKKGLG KVEEKKAVAL KDGHMDDCFT FFMALEEESK SARVIRKCSS
     VLNRFLKGIE ALQREGKQSN DWIRVDLKEV LKLMEDLIKY FAQPDEADDF EEKQNRLRAL
     RSRQDLFQEE GVLNMILDTI DKFSEMEALP DFAGLIGEET QMMWEEIATY LYLLVAAMIK
     GNHYNCAQFA AAQRLDWLFG RLANPQSAEG ILDVLYCVLT ESPEALNMIN EDHIKSVISL
     LEKVGRDPKV LDVLSSLCEG NGMAVRSSQN TITKHLLPGK DLLLQTKMMD HVSSMSPNVL
     VAVQEGSSQF RRWYYEAEVE HIEEMTKLKP YLRIGWANSL GYRPFPGSGD GWGCNGVGDD
     FYSYGFDGSC IYCAGKGKQV GNRKLQKGDI VGCILDLTIP EIRFTLNGQQ ISAFYKNFNI
     DGYFFPVMSL SAKVSCRFIF GSCHGLLRFG PPSGFSPLAE AISEQLEIAE YFSFGKLAKN
     IFYGPSTMHS NAKPFVPTPI DISSSILPHF AMEFHEKLAE NLHELWAMRK IELGWTFGEV
     RDELQRHHPC LTSFDKLPVT EKNYNINLAI DTMKTIDALG YNMVVDKPPT RLRPIRLPQN
     YQQSNGFKPQ PLDSHEISLD ENITPLIDAL AKNTHNVWAK EKIHRGWTFG LNEFVDSNQK
     RSPHLVPYDL VDQRIKDANK ESAAEFIKAL QLFGIFLEPP VHEHDEGAEK ELLASRTPSL
     IYRAEATYAV TSGKWYFEFE VLTSGFMKVG WIDIGAPPDT DLGLDERSYG FDGYLKILVY
//