ID   A0A0N4V7Q3_ENTVE        Unreviewed;       649 AA.
AC   A0A0N4V7Q3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=CARD domain-containing protein {ECO:0000313|WBParaSite:EVEC_0000632401-mRNA-1};
OS   Enterobius vermicularis (Human pinworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX   NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000632401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EVEC_0000632401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the AAA ATPase family.
CC       {ECO:0000256|RuleBase:RU003651}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC       family. {ECO:0000256|ARBA:ARBA00010044}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC       family. {ECO:0000256|ARBA:ARBA00010550}.
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DR   AlphaFoldDB; A0A0N4V7Q3; -.
DR   WBParaSite; EVEC_0000632401-mRNA-1; EVEC_0000632401-mRNA-1; EVEC_0000632401.
DR   Proteomes; UP000038041; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd19501; RecA-like_FtsH; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.1690.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.20.58.760; Peptidase M41; 1.
DR   HAMAP; MF_01458; FtsH; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR005936; FtsH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000642; Peptidase_M41.
DR   InterPro; IPR037219; Peptidase_M41-like.
DR   NCBIfam; TIGR01241; FtsH_fam; 1.
DR   PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR   PANTHER; PTHR43655:SF2; SD01613P; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF01434; Peptidase_M41; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00674; AAA; 1.
DR   PROSITE; PS50209; CARD; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU003651};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          551..594
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   REGION          602..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..649
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   649 AA;  72000 MW;  62D484FCBC4BC686 CRC64;
     LLFRPQVWQQ LFLTVGVLLV LYLVYDSLTA REISWKEFYA NYLERGLVRF SDDSSCLYIL
     ESVYFNIGSV ESFERSLAAA QSHLGIPAEN QIPVIYKNEI TLSYLLPLAF VIYFFRSVSK
     GMPKGKDGRK LGGFPFFGAM GQSTARLINK NDIKVAFKDV AGCEEAKIEI MEFVNFLKNP
     QQYKSLGAKI PKGALLTGPP GTGKTLLAKA TAGEANVPFL SVSGSEFLEM YVGVGPARVR
     DMFAEARKNS PCILFIDEID AVGRKRGRNL GGSHSEQENT LNQLLVEMDG FSTDEASVIV
     IAATNRVDIL DPALLRPGRF DRQIYIPVPD IKGRASIFRV HLAPLKTSLN KTDLARKLSA
     RTPGFSGADI ANVCNEAALV AARDGGEEIT MKNFEQAIER VVAGMEKKSQ VLQPEEKKTV
     AYHEAGHAIT GWFLEHADPL LKVSIIPRGK GLGYAQYLPK EQYLYTKEQL LDRICMMLGG
     RVSEEIFFGR ITTGAQDDLQ KVTQMAYSQV IVTYGMSAKV GPLSFQAPAP GEMAFDKPYS
     ESTAQLIDQE VRDLVNKALN RTRELLLSKQ PQIEKVAQRL LDKEVLSRED MEELVGPRPF
     AEKSTYEQFV EGTGGLDEDT SLPKGLESWN KQKNQEPEKN GECGKKGNK
//