ID A0A0N4VJL4_ENTVE Unreviewed; 596 AA.
AC A0A0N4VJL4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial {ECO:0000313|WBParaSite:EVEC_0001103501-mRNA-1};
GN ORFNames=EVEC_LOCUS10360 {ECO:0000313|EMBL:VDD95609.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0001103501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0001103501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD95609.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; UXUI01010768; VDD95609.1; -; Genomic_DNA.
DR STRING; 51028.A0A0N4VJL4; -.
DR WBParaSite; EVEC_0001103501-mRNA-1; EVEC_0001103501-mRNA-1; EVEC_0001103501.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000274131}.
FT DOMAIN 15..458
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 134..331
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 521..594
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 596 AA; 66313 MW; F9B3A0EBEE896F2F CRC64;
MIGVFNVRRF STAKKISRLL IANRGEIAIR VIKTARRMGI ETVAVYSDAD RNSLHVAKAD
FAYHIGPSSS VQSYLNIDRI IEVANKAKVQ AIHPGYGFLS ENATFAECCA KAGLIFVGPP
PRAIRDMGAK DVSKRLMAES GVPVIRGYHG TDQSDQKLRE EATLIGYPVM LKAVYGGGGK
GMRVVLEESE FAEKLSSARS EAHKAFGDSS MIVEKFIERP RHIEVQVFGD THDNYVYIWE
RDCSVQRRHQ KIIEEAPAFG INAETRRKLG ETAVQASKAI GYVGAGTVEF IMDKNGQFYF
MEMNTRLQVE HPVTEAISGL DLVEWQLRVA EGEELPLKQD QVQLGGHAIE ARIYAEDTRS
GFLPTAGKLI HVAIPNSVRV DTGVRQGDEV TIHYDPMIAK VIAWGSNREK AIVKLQKALN
DTHIVGVPTN IEFMIKTLGN PDFQKGDLYT DFIKDHEKEL FEEERLSEND LCDAITAYYL
LTKPLHSRQH YKKTGILLLQ LFGEKQLQFA LPKESEVFKN EEDEKLEAHS PIPGVIERVL
VSQGEQVKQG QALIVMIAMK MEYIIRAPSH ATVTALHCSA GDNVSKGSTL VSFASE
//
