ID A0A0N4X9J0_HAEPC Unreviewed; 642 AA.
AC A0A0N4X9J0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Peptidase A2 domain-containing protein {ECO:0000313|WBParaSite:HPLM_0002103201-mRNA-1};
GN ORFNames=HPLM_LOCUS21024 {ECO:0000313|EMBL:VDO87414.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0002103201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0002103201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO87414.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO87414.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAF01022850; VDO87414.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4X9J0; -.
DR STRING; 6290.A0A0N4X9J0; -.
DR WBParaSite; HPLM_0002103201-mRNA-1; HPLM_0002103201-mRNA-1; HPLM_0002103201.
DR OMA; ECLSITC; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR PANTHER; PTHR37984:SF8; PROTEIN CBG26711; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR SUPFAM; SSF50630; Acid proteases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT DOMAIN 340..358
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT REGION 560..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..642
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 74552 MW; EF96A5F5A99AC6FE CRC64;
MAVRAAIINS ETKERLPVII LLDSGAQASF ISKAAVKRHK LNVFEEAPMT ACAFGAALRS
VIPDVIIGID YLWDILTLQE PVTLPSDNIV IPLNVARYQV NSKSIIRDSR VPEDKKRDLI
LLKLDDAAYR KYADDILPSQ PHEIDFNTTV RNLQKLFTSK KTLIRRRYEC LSITCPPLTQ
DNVPFRDYAN TIKRMDEDAA LKEMDYTSMK TLQFVARLQD PSLLKIRLRM LRRLDTQAED
VPLTIEDLVA ECENITALKV DNANMEASHD VHAVQKKKVK CFECGGPHYK TFCPLLMKQF
PKKPKRMHHR LKRNKCKDVA TFSAEHARTY INVDVSGHKL RFQLDTGADI TLISRHTWKK
LGFPALEPYA TPVKTADGSP MKIDGRFHIE FSVKDRPAYK ELQEKYHSRM GIEHIRSPPL
HPQSNGAFRR HAEESFTQIE GRRELLTEFL KCYRRMPCTT TPKQLSPAEL FLGRQLRTTL
TLLKEEIRNE KGSRKTRMER QHNLHHEARE RSYDIEDPVY IRNYRSGEQN WIPAHVKNLY
GRVLYDVSME DGQLWRRHTN QMRTRSQPSA TDQAKKTVGE HSQYENPQEK YNVVHNEEVQ
PTRDFSDESM DPNATATVLD RMNRQRRPPN RLQVRPRKKT YM
//
