ID A0A0N4XCT2_NIPBR Unreviewed; 688 AA.
AC A0A0N4XCT2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 {ECO:0000313|WBParaSite:NBR_0000028201-mRNA-1};
GN ORFNames=NBR_LOCUS283 {ECO:0000313|EMBL:VDL62724.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000028201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000028201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL62724.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYSL01000100; VDL62724.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4XCT2; -.
DR WBParaSite; NBR_0000028201-mRNA-1; NBR_0000028201-mRNA-1; NBR_0000028201.
DR OMA; KCSERAR; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13250; PH_ACAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045258; ACAP1/2/3-like.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23180:SF399; BLOWN FUSE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR23180; CENTAURIN/ARF; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 194..292
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 334..462
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 563..595
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 596..628
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 298..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 75648 MW; 5D824F391CD2AE5B CRC64;
MSEESFSGNV LAQKTLNSLS EACGRTVSLM RDYHEQSCTN LYGLIASELV KVQEARVHFD
SMSTSMDEAL SRNAASTRTR PSDAADGRNA LTAVGACFAH TTLDYVAQIN IAHAQKDHLI
IDALWSFIRE TSSYFSRGHA VFDDWTAHDD GAVSDSITAL SAKSKLIQRK MQDIHSLVPK
EMFQHFSGMP PDPDVMMEGY LYKRSSNAFK TWNRRWFQIK DNKLLYSHRT AESEEPTVME
ENLMLCLVRP APASVDRVGC FELVTPTRSH LLQADSEALC NDWMRALQRT ILALHESDDV
SRPSSSSKSD TRKTAAPANS NSTSVSSPTV SDVTTTFEQI RRVPGNERCA DCGSEQPKWV
SINLGVVLCI ECSGVHRSLG VQTSKVRSLT MDSIDPELRD VLLSLGNSQV NAIYLAHLPD
KNIVPPPAVD TSSRQVREAW IKAKYVERRF AVSSCDRARS NAIVRKEHLL ARHRPSTSSV
GSGVLRSSSY EDSLDTNKDT NDEMGKCLNG MRPKRLSSCG SDPSLAKFES TDWEVISECA
RCGDVLGLLR SLAAGADINC GRSGTTALHI ATKNGQTAAV EFLLLNGAKI NVLDEKLNTP
LHLAAAEGNT LQVCQLLKRG ADKSLKNADG VTPLEIAVEG KHADIVTLFR VHTMRDEFNE
EFNNPMDDTV DSVISDITRR AAVSRSSE
//
