ID A0A0N4YJ21_NIPBR Unreviewed; 1090 AA.
AC A0A0N4YJ21;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=VWFA domain-containing protein {ECO:0000313|WBParaSite:NBR_0001694201-mRNA-1};
GN ORFNames=NBR_LOCUS16943 {ECO:0000313|EMBL:VDL80556.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0001694201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0001694201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL80556.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYSL01022479; VDL80556.1; -; Genomic_DNA.
DR STRING; 27835.A0A0N4YJ21; -.
DR WBParaSite; NBR_0001694201-mRNA-1; NBR_0001694201-mRNA-1; NBR_0001694201.
DR OMA; CKIAPAD; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00063; FN3; 1.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF20; COLLAGEN ALPHA-1(XXI) CHAIN; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00092; VWA; 2.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 157..331
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 368..546
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 814..908
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 21..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 118772 MW; 9DCFF729A77578CD CRC64;
PLPTDASGNY IVVSEGEAVS KELPTDESGN VIYPVTKPDG TPESSAVPPL PTDDSGRILY
PVVRPDQIPA DREGSAVPTY GSGRPVQYIV VTEDGRPLPT NEYGSAIGEN GSPLPTDESG
RPLDHTNSPF PTNAYGEYVV PPSRRPSAHC LVNSHIELII VLDTSNSVKV LDYRVMKELL
KSFLFDHFDM TKNKVRVGVI KYGETADIPI SLGDYDYVDD LLHRISETRR VKGKPMLGSA
LKEVAGEILI SGTDEVPKFV LLLKNGLSSD SFQEEVDTLK NDIGAELFVV EAGDDASYAQ
SLQITSEDRV VRIPRWRGTD SEVLGPIADV ICKIAPADPA RLVTWPARKV TATSKAARAC
TQIDYQADVI IMLDSSENFS QEEFDEMKES IADLADVGFD LAPDVVRIGF VVYSDKVAVP
VALGHYEDKI DLIQQISDTE KINDGVAIAL YGLNAARQQF QLHGRENATR IVIMITNGRN
RGNAAPAAED LRETYNVQLF VLAVATDSEG LSTLKRIAGT EYPDRVIEVP TAFELDERTA
DISRHLCGYT TPAQISTATE PTLHRTTKRE VSSDSRSQTI FPRGISRGLK FPPLCSDGIK
RPYQFNILVD VTARSSPQDF RLAIDHLSLF FQKRFAPDDN MLQFNIMTVN SKKVLDARAG
LVVGEIVFAL NDITQNGDDV ESAKLGVGVD SLVEMSNENY IIGSHKIMLI ISADSTSSDA
ALPSAEYATG DFGQNIIGLS VRKPSTDLLT NMAGTGTRVI HLDWTSPNEL FNSWFAYAIC
DYVTATTIKT APTTTKAKSI TTRKTTPAPA AVSAATNVEA VPLSPNSFSV SWTCCTNRKS
NYTILYTHDT SIPQKNWQKR EATCRDSFGT TIKDLPTDHQ YTACVVAANG KESPSEAKLE
DYTTIAEAYE PVEIAPCNCL CDRGEAVLRP SCDVAVDEYR PIATLPPATE GECPCKIKSH
GGRCPFGYIL AKGQCYDVDE CAVDNGGCSH GCVNTPGGHY CACPYGMTRD PLDPNTCVNA
ANSFDRIAQL LSQYLHANAQ QAAGSMRTDA IATQQKTKYK ATIKSGDGNT ITFEWSSVPA
VVRRAFRWLF
//
