ID A0A0N5AJK0_9BILA Unreviewed; 1461 AA.
AC A0A0N5AJK0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=EF-hand domain-containing protein {ECO:0000313|WBParaSite:SMUV_0000464101-mRNA-1};
OS Syphacia muris.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000464101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMUV_0000464101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 451379.A0A0N5AJK0; -.
DR WBParaSite; SMUV_0000464101-mRNA-1; SMUV_0000464101-mRNA-1; SMUV_0000464101.
DR Proteomes; UP000046393; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1079..1097
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1162..1191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1267..1290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1306..1341
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 338..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 627..686
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 228
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 568
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 942
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1461 AA; 167962 MW; A5E57CBEFC5D31E1 CRC64;
MIRRQCKAII EWGPFEYFIL MTIIGNCVVL AMDQHLPKND KNMLGEWLEF TEPYFMGIFC
IECSLKIIAF GFVLHKGSYL RSGWNIMDFI VVVSGVVTML PFTPSGNEGG GSVDLRTLRA
VRVLRPLKLV SGIPSLQVVL KSILCAMAPL LQIGLLVLFA IIIFAIIGLE FYSGIFHSTS
TRNATGAYKC EGDGLLCLSG WVGPNYGITS FDNIAFAMLT VFQCITMEGW TSIMYYTDDA
LGSTYNWAYF IPLIVLGSFF MLNLVLGVLS GEFAKEREKV ENRRDFLKIR RQQQIDRELD
GYLDWILTAE EAILRGDPTE EERDAIYESR RLNEKRRQKA ASKQRSLDTE EEQEEEDEEY
EATYDEQSAY SVVTIRFRLR TRSLVKTQVF YWSVIMLVFL NTVCVASEHY GQPDWLTVFL
RYAEYVFLGV FMFEMCLKIF AMGTTAYFKS NFNRFDCIVI IGSAFEVIWA EVKGGSFGIS
VLRALRLLRI FKLTSYWLSL RNLVRSLMNS MRSILSLLFL LFLFSVIFAL LGMQLFGGKF
NFPSGHPYTN FDTFPVALIT VFQILTGEDW NEVMYYAIES QGGVYKGGFP YCIYFIVLML
FGNYTLLNVF LAIAVDNLAN AQELTAADEA EERAYEMSQD SESMNDEMKI PLDSKRNSID
TENKTAADLC QLQRDMEEEC EEEEESPFGG RKPMVPFSSM FIFSPTNPIR RFAHWIVNIK
YFEITVMVVI LLSSMALSAE DPVDENNYRN SVLQYFDYLF TGVFALEMTL KLIDQGVILH
PGSYCRDFWN VLDGVVVVFA LLAFSFAFSG AEGAAGKNLN TIKSLRVLRV LRPLKTIKRI
PKLKAVFDCV VNSLKNVFNI LIVYFLFQFI FGVIAVQLFN GKFFYCTDKT KKYAHECQGQ
YFVYTSQEEP PRVETREWRL RPFNYDNTVN AMLTLFVVTT GEGWPGIRQN SIDTTEEDQG
PSPFYRVEVA LFYVMFFIVF PFFFVNIFVA LIIITFQEQG EQELSEGDLD KNQKQCIDFA
LNARPRSLFM PEDKNSTRYK LWKIVSSSKF DLLIMVLISL NTAVLMTKHH NISEWLERSL
RICNTVLTFM FTIEAGMKIL AYGVRNYFRD GWNRFDFVTV VGSITDALVT EFGGHFVSLG
FLRLFRAARL IRLLQQGYTI RILLWTFIQS FKALPYVCLL IGMLFYIYAI VGMQVFGNIW
LDPSTELNRH NNFQTFFNSL ILLFRCSTGE AWQDIMMACT AGKYCVTPNS DQENFAKGKT
CGTQLSYAYF TSFVFLSTFL MLNLFVAVIM DNFDYLTRDS SILGPHHLDE FIRHWAEYDP
AATGRIHYTE MYDMLRNIAP PVGFGRKCPY RLAYKHLIRM NMPVADDGTV RFSTTLFALI
RESLSIKMRP VEEMDEADEE LRQTLKKMWP LKAKKNMIDL VVPPNSELCF QKLTVGKIYA
GLLILENYRA KKSGTEQNLK F
//
