ID A0A0N5AKE2_9BILA Unreviewed; 1067 AA.
AC A0A0N5AKE2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
OS Syphacia muris.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000496101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMUV_0000496101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A0N5AKE2; -.
DR STRING; 451379.A0A0N5AKE2; -.
DR WBParaSite; SMUV_0000496101-mRNA-1; SMUV_0000496101-mRNA-1; SMUV_0000496101.
DR Proteomes; UP000046393; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 2.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 457..475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 512..537
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 601..618
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 638..656
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 686..705
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 725..742
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 786..806
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 812..836
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 65..336
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 398..570
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT DOMAIN 576..863
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1040..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 120060 MW; 2F5284C9015FD4F2 CRC64;
MYSTVVLKSA KGRNWFISAP STRVMFLLKE RNEMPALFTE MNELQRAGPV EEWRETARWV
KFEEDVEEGG NRWSKPHVAT LSLHSLFQLR SCILNGIVIV DSASETLNDL IEEILEAFSD
KKQIDSKERD QIRQVLSRRH RHQYEQAKGA SNGVGSGQGG FLNAVRSISD MGKSLSGRNI
SKAAEVTEST ANKSPNLLLP KVESSDISRE SSHSDVKGNV HFMKKLPLGA EASNVLVGEV
DFLTRHITAL VRLKKATVLG DLTEVPVPTR FFFVLLGPTG HGSQYRGIGR AMATLMSDEV
FHDVAYKARN RRDYLDGVDE FLDQVTVLPP GEWDPNIRIE PPSQIPSQEK RKNAENLFLE
VQPPKIDSCT FMHLSYLKKP LDDDEPHGTD PALKRTGKLF GGLFADIKRK RRWYWSDFTD
SLNLQCIATF CFMYFALLAP IVTFGGLLEE ATHQRMAAME NLFGGAICGI LYHLFSGQPL
TIIGSTGPVL VFETIVYDLC DSRGIDYLSF RFWVHVWTAL ILFVMVITDA SSLVSYITRF
TEESFATLIA VIFIYEAIKK LANIRNQLGV INYSYDVDIN DCYAFHGHPT GSNCFYLYDK
LLMSLVLMIG TFTLAITFKK MRNSCYFPSR IRQIFSDFAV MISIFIMTLI DYFVGINTPK
LNVPSSFRPT WEGRGWIIPP FNGNPWWTAP IAFVPALLAC ILIFMDQQIT TVIVNRKENK
LKKGCGYHLD LFVLAALIFI VGFLGLPIYV AATVLSINHV NSLKVESESR APGEVAQFIG
VREQRVTGIV TFLFIGLSVM MTGLLSHIPM PVLYGVFLYM GIAALGGIQL FDRILLLFMP
MKYQPDTIYI RHVPISVIHR FTFFQVACLG VLWTVKSIKA TSISFPIMLV VMVAVRKFME
KFFTEKDLKY LDDKMPDFHL RKKEDMSKVE EGEEIDIDLD ENQGTIHAVK TKAHLHIPMA
SGNIIKIPLA AIQEPSHNIN ISNEVNQSGL WKQIASESRM SYTKEAEEKY SLDGAVSDSA
NEKLDETLDD EEAIMINIVR PSPTSSSAQL NGEKAPLLSE KSSDQPL
//
