ID   A0A0N5AQS7_9BILA        Unreviewed;       844 AA.
AC   A0A0N5AQS7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Syphacia muris.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Syphacia.
OX   NCBI_TaxID=451379 {ECO:0000313|Proteomes:UP000046393, ECO:0000313|WBParaSite:SMUV_0000705201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMUV_0000705201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A0N5AQS7; -.
DR   STRING; 451379.A0A0N5AQS7; -.
DR   WBParaSite; SMUV_0000705201-mRNA-1; SMUV_0000705201-mRNA-1; SMUV_0000705201.
DR   Proteomes; UP000046393; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF58; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        439..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        484..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        553..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        580..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        619..639
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        671..690
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        759..777
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        783..808
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          113..140
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   844 AA;  96708 MW;  93CBA64CCD52F9CE CRC64;
     MGSLLRSETM CLAQIFLQTE SAYACVAELG ELGLAQFRDL NAEISAYQRK FVTEVKRCDE
     MERKLRELTT FTKILIYYYI VTDYCFIEGE IAKDEIEIPD VNEHIPAPLP KDMNDLEAKF
     ERLEEELLKV NENTNSLKKD YNNLIELNEV LRHVQQFLDE GQRERAKAQI AEAQQAQLDA
     ESYSGSNKLR AVSFVDDFMV QKLDNEMKYI AGVLPKKKAI SFERTLWRAC RGNAFVRTSD
     ITGIDESLQD EPESKVVFII FYYGDQLGNK CTKICDGYRA SLYNCPGTAE ERGQMRHDVE
     IRIEELHAIL RQTMEHREKV LRATALNYKT WTIKVLKIKS IFHTLNMFSL DITQKCLIAE
     CWIPVTDIPL VRHQLQVGAE ISGSSIPPVL NKMEFTDEPP TFHRTNKFTR GFQNIVDSYG
     IATYREINPA PWTIISFPFI FAVMFGDAGH GIIMFLAALA LVLFENRLIA MKIRDEIFNT
     FFGGRYVILL MGIFSIYTGL VYNDIYSKSI NIFGSGWKNP YRLGPYPFGV DPIWNIATNK
     LNFLNPLKMK MSVIIGIAQM TFGLMLSLGN YIYFRSVVDV VFIFIPELVF LACIFIYLCV
     QIIIKWLMFW VEAKEIFGWY YPSSHCAPSL LIGLINMFMM KSREEGYVQK NDTSTELDQC
     YLQQWYPHQS LVEMILLVLA VVSIPVMLLV KPIILKIRAS RGQPVKTHGG GESEEFSFGD
     TMVYQAIHTI EFCLGCISHT ASYLRLWALS LAHAQLSEVL WSMVFNIAFT MGGWAGVAGQ
     YIIFWVFAIL SISILILMEG LSAFLHALRL HWVEFQSKFY GGTGYQFEPF SFEAILRVAE
     GLDN
//