ID   A0A0N5B7G5_STREA        Unreviewed;       624 AA.
AC   A0A0N5B7G5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   22-FEB-2023, entry version 23.
DE   SubName: Full=FYVE-type domain-containing protein {ECO:0000313|WBParaSite:SPAL_0000199100.1};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0000199100.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0000199100.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Negative regulator of epidermal growth factor receptor (EGFR)
CC       signaling. {ECO:0000256|ARBA:ARBA00003580}.
CC   -!- SIMILARITY: Belongs to the lst-2 family.
CC       {ECO:0000256|ARBA:ARBA00008755}.
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DR   AlphaFoldDB; A0A0N5B7G5; -.
DR   STRING; 174720.A0A0N5B7G5; -.
DR   WBParaSite; SPAL_0000199100.1; SPAL_0000199100.1; SPAL_0000199100.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15731; FYVE_LST2; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR043269; FYVE_LST2.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46465; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR   PANTHER; PTHR46465:SF2; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          488..548
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   REGION          297..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..344
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  71664 MW;  06D295CFEEE22862 CRC64;
     MQSILKLVRK PRMDDWSPLA KFYYADEALN SITLELESFD GRRDQARCDQ LVQRLRQAQD
     RLIHIIYEMI AIIFPNEADR ASRDYRVKFP DEIIHDSLPG QLWFGAECLA AGSNIVDREF
     ESEQIRPIAK TLTKHLDQMR ELLKDQSLRN PHQYTDKIKA SLKVFDYLFA EFEFHYVSAM
     VPVKSVKEHD AQLDIAVLFS ETLNKAMQKK YITQDQIDMF DPNVMFAIPR LAIVWGLLYY
     PEGALNVDRE PQQLSEMFRQ YCHLLLTMRS LLRDMSPEEL RQLEMTLVTG ECITTPCSKK
     SSKQCEPSTS SSSISEMERK LSGEPNDFTN DGKVLKKDSN ASDNDPESKI VSISLQDAID
     CRVEIEHDAA DDLRLLEAFQ NMNLTEVYMR YEKSIQKKSR RMYKDRNELI HRLFICIAGV
     ADQLQTNYSQ DVRKLLKMVL QPNEIVPVYE VNGKTARVPE NEEETGIEVQ EETLPLPSFI
     VGVRWVPDEE CDQCTSCNAP FTIIRRKHHC RNCGRIFCSY CSSSRLALPE LGYDKKVRIC
     DMCYYYKMNP TTTDPSLTSM RRDVQNSTYG NEENHLSPGS SDISSPTTAT IARNCNHESG
     SNYTPSTTLT SIHEPIEGTN SISA
//