ID A0A0N5CUD9_THECL Unreviewed; 1557 AA.
AC A0A0N5CUD9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Nuclear export mediator factor NEMF {ECO:0000313|WBParaSite:TCLT_0000387601-mRNA-1};
GN ORFNames=TCLT_LOCUS3865 {ECO:0000313|EMBL:VDN00887.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000387601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000387601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN00887.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; UYYF01004268; VDN00887.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CUD9; -.
DR WBParaSite; TCLT_0000387601-mRNA-1; TCLT_0000387601-mRNA-1; TCLT_0000387601.
DR OMA; RRVMWFE; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR CDD; cd12689; RRM1_hnRNPL_like; 1.
DR CDD; cd12424; RRM3_hnRNPL_like; 1.
DR CDD; cd12427; RRM4_hnRNPL_like; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; NF041120; RqcH_arch; 1.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 1020..1094
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1113..1186
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 699..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 357..394
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 699..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1557 AA; 176317 MW; A98D6026699F0AFB CRC64;
MYVNECVSVC ERSLESVGRC YLLQKFLLVG VGARFQCIWL LPETVRCVYF RYCNVVMIGM
KNGFTTLDVF AAVHDLKKLV GHRVANVYDV NPKTYLIRIQ NADDKCFIMF ESGCKIYKTT
FDWRKAQFPS SFSMKLRKHI RQKRLQSVNQ LGIDRIVDMQ FGSCEQACHV IVELYDRGNV
LLTDHNYIIL NALRPRTAKE LDLRFIVHEK YPLEAARQVA SCLTKDELIM RLNNAKEGDS
LKRFFAPLTQ YGSALIEHSL KAVGISKDAK IGISISKEEA DISKLLNALQ LAQEIFNNVR
QNPTPGFLMY KEDVKTDGTI VETYQEYHPF KFSQFNERQI KQFSSFSECV DEFFSKLESQ
KADLKALNVE KEAMKKLNNV IKDQQERIAA LELAQVEREQ MAELIELNTA LVDKALLVIR
SAIANQLSWE AIEEMRVKAC NAGDPIAASI VGLNLNSNEM VLLLKDPYQP ETVPKKVTIN
IALSSHQNAR KLHTEKKAAQ EKQQKTISAS SKALKSAQIK TKQTLEAVRT KSEVMKKRRV
MWFEKFLWFV SSENYLVIGG RDAHQNELLV KKYLRPGDIY VHADVWGASS IVIRNKLGGG
DIPVRTLNEA ATMAVCYSSA WEAKITASSW WVHEHQVSRT APTGEYLTPG SFMIRGKKNY
LPTCQLQMGF GVMFKLDEDS LERHKEERKI ASILLPENDT RKESDAENDI SINNSEDEKE
EDYPDIQVNL KGIMREVKGA EDESYTIVQV GPSVQKKHTS QQAGNTQGNV EVTEAQRAKE
SKKIRPMNRR QKHKIEKIKK KYGDQDEEER QLRIMLLGSK PKDTDKVEKK TSSNKPTESM
DSSNVLLKNT NGHVSEENKI DNYAKKSKRL AELLEFSNFP DEEDEMLETD VALMDAEETK
MLNSLTWKPL EEDVILFAVV VVAPYQTMLN FKYKVKLTPG TGKKGKAAKC AIALFQRDKF
ASSQELDLLK VLASDDQISR NIPGKMDAEI KDDDNVSQAP SSKRYRRDDN VDPTNPDPSI
VVHVRNLSPK ATEADLLEAL SHFGPISYAT CMPGKRMALV EFEEVEGARS CVVYAQTNQI
YVAGQAALFN YSTSKVIQRL GLESETPNHV LILTIYNAQY PVNVDVIHQI CEPHGFVKRI
AMIRRTMLQA LVEFESTEIA KKAKHAMNGA DIYSGCCTLK VEFAKPEHVK VTRNDMDQWD
YTKVPQSVQL SFASFTVRRN SHNYSKRKKK GITSIRKNLE RRGYSGRGRG GPPNDYSYHE
DRYGGSYGRG RGSYDDYEAG YSRSEGYVRG DGYSRGDVYY GNRGSGRGGF GRGDSGYGRG
SYARGRGNGS GHYDDDRDYY NGDGPVMMIY GIDQDNFNCD KLFNLLCLYG NCEKIKFMKS
KTDTAMAQMG NVRQVYTAID NLHGTVIFGN KLALRPSKQQ VLHEIRDPFI LPDGTPSYRD
FNNSRNQRYT TPELAGRNRI VKPTHVLHWY NAPVTMTEDK LKELFVDKGA VEPDKIIIFP
QRSERSSAGI CEFTSTERAT EALMLANHTP VDSPVGKAPY IVKLAFAGGR DGKDFRI
//
