ID A0A0N8CFU0_9CRUS Unreviewed; 760 AA.
AC A0A0N8CFU0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=EOG090X01A3 {ECO:0000313|EMBL:SVE79958.1};
DE SubName: Full=Mitofusin-2 {ECO:0000313|EMBL:KZS16364.1};
DE SubName: Full=Transmembrane GTPase Marf {ECO:0000313|EMBL:JAL67787.1};
GN Name=EOG090X01A3 {ECO:0000313|EMBL:SVE79958.1};
GN ORFNames=APZ42_017993 {ECO:0000313|EMBL:KZS16364.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAL67787.1};
RN [1] {ECO:0000313|EMBL:JAL67787.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT "Daphnia magna gene sets from two clonal populations assembled and
RT annotated with EvidentialGene.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAL67787.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KZS16364.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS16364.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS16364.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:SVE79958.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CH-H-1 {ECO:0000313|EMBL:SVE79958.1}, and FI-XINB3
RC {ECO:0000313|EMBL:SVE82924.1};
RA Cornetti L.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001270};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
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DR EMBL; GDIP01135927; JAL67787.1; -; Transcribed_RNA.
DR EMBL; LRGB01000725; KZS16364.1; -; Genomic_DNA.
DR EMBL; LR010339; SVE79958.1; -; mRNA.
DR EMBL; LR013305; SVE82924.1; -; mRNA.
DR AlphaFoldDB; A0A0N8CFU0; -.
DR STRING; 35525.A0A0N8CFU0; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR PANTHER; PTHR10465:SF0; TRANSMEMBRANE GTPASE MARF-RELATED; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 632..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..347
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 710..737
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 760 AA; 85905 MW; 669B47DA6F8F87D5 CRC64;
MMSGQIQRSS SVVIGVNGSP ANNSLSISPT TAIQSPLQIF VRAKKRINDI YGEVEQYVSD
SCKFLSALPK DSDLITKEEL VVVNSHVEKV KGIREVLSRD HMKVAFFGRT SNGKSTVINS
MLRERILPSG IGHTTNCFIQ VEKSENDESY LISEDSLERK NVKSVSQLAH SLCTGSLGDS
ALVRVYWPTD KCPLLRDDVV LVDSPGIDVS PNLDSWIDRH CLDADVFVLV ANSESTLMLT
EKNFFFKVSA RLSKPNVFVL NNRWDASASE PEYLEEVRRQ HMLRTVDFLV DELKVCGTRT
EAEQRVFFVS AKEVLQARTN EFKGLPLNTG IVTDGFHGRY FEFQDFERKF EECISKSAVR
TKFDQHTKRG KAVVGDARNV MEVLLERASA KRAAKSQSRR EVLDHLDFTE KQLQLVTVEM
KDKICKMVEE VEHKVSKALN DEIRRLSVLV DEFHAPFHSE SLVLQVYKKE LHNHVEACLG
SNLRARLSTA LALNMDQSQK EMIERVTSML PSEKKQLGLG MIPRREPFEV LYRLNCDNLC
ADFSEDIEFR FSFGITSMIQ RFTGKGKIAP WVINNYTESI PRSIGSHHSQ PGQLIPQGVE
DWSMLSRIAI ASVTSQGTMG GLLVAGFLMK TVGWRLIFAS GVIYGGLYLY ERLTWTNKAK
ERAFKRQYVD HATRKLRLIV DLTSANCSHQ VQQELSSTFA RLCHLVDGTM NDMQGDIKQL
ETELRSLDEV ATSAKVLRNK ANYLVGELDR FDKSFLTPDN
//
