ID A0A0N8D9Y9_9CRUS Unreviewed; 1260 AA.
AC A0A0N8D9Y9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE SubName: Full=Furin Protease 2 {ECO:0000313|EMBL:KZS13967.1};
DE SubName: Full=Proprotein convertase subtilisin/kexin type {ECO:0000313|EMBL:JAM49380.1};
GN ORFNames=APZ42_020548 {ECO:0000313|EMBL:KZS13967.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAM49380.1};
RN [1] {ECO:0000313|EMBL:JAM49380.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT "Daphnia magna gene sets from two clonal populations assembled and
RT annotated with EvidentialGene.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAK62486.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RT "EvidentialGene: Evidence-directed Construction of Complete mRNA
RT Transcriptomes without Genomes.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:JAM49380.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KZS13967.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS13967.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS13967.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; GDIP01240467; JAI82934.1; -; Transcribed_RNA.
DR EMBL; GDIP01239359; JAI84042.1; -; Transcribed_RNA.
DR EMBL; GDIP01238058; JAI85343.1; -; Transcribed_RNA.
DR EMBL; GDIP01219118; JAJ04284.1; -; Transcribed_RNA.
DR EMBL; GDIP01186610; JAJ36792.1; -; Transcribed_RNA.
DR EMBL; GDIP01186609; JAJ36793.1; -; Transcribed_RNA.
DR EMBL; GDIP01175619; JAJ47783.1; -; Transcribed_RNA.
DR EMBL; GDIP01153967; JAJ69435.1; -; Transcribed_RNA.
DR EMBL; GDIP01149774; JAJ73628.1; -; Transcribed_RNA.
DR EMBL; GDIP01149773; JAJ73629.1; -; Transcribed_RNA.
DR EMBL; GDIP01147126; JAJ76276.1; -; Transcribed_RNA.
DR EMBL; GDIP01143479; JAJ79923.1; -; Transcribed_RNA.
DR EMBL; GDIP01143478; JAJ79924.1; -; Transcribed_RNA.
DR EMBL; GDIQ01189239; JAK62486.1; -; Transcribed_RNA.
DR EMBL; GDIQ01146509; JAL05217.1; -; Transcribed_RNA.
DR EMBL; GDIQ01146508; JAL05218.1; -; Transcribed_RNA.
DR EMBL; GDIQ01129771; JAL21955.1; -; Transcribed_RNA.
DR EMBL; GDIP01139426; JAL64288.1; -; Transcribed_RNA.
DR EMBL; GDIP01138021; JAL65693.1; -; Transcribed_RNA.
DR EMBL; GDIP01135224; JAL68490.1; -; Transcribed_RNA.
DR EMBL; GDIP01135223; JAL68491.1; -; Transcribed_RNA.
DR EMBL; GDIP01114974; JAL88740.1; -; Transcribed_RNA.
DR EMBL; GDIP01114973; JAL88741.1; -; Transcribed_RNA.
DR EMBL; GDIP01112432; JAL91282.1; -; Transcribed_RNA.
DR EMBL; GDIP01112431; JAL91283.1; -; Transcribed_RNA.
DR EMBL; GDIP01088228; JAM15487.1; -; Transcribed_RNA.
DR EMBL; GDIP01088227; JAM15488.1; -; Transcribed_RNA.
DR EMBL; GDIP01066084; JAM37631.1; -; Transcribed_RNA.
DR EMBL; GDIP01066083; JAM37632.1; -; Transcribed_RNA.
DR EMBL; GDIP01054335; JAM49380.1; -; Transcribed_RNA.
DR EMBL; GDIP01054291; JAM49424.1; -; Transcribed_RNA.
DR EMBL; GDIP01052943; JAM50772.1; -; Transcribed_RNA.
DR EMBL; GDIP01052942; JAM50773.1; -; Transcribed_RNA.
DR EMBL; GDIP01051732; JAM51983.1; -; Transcribed_RNA.
DR EMBL; GDIP01051731; JAM51984.1; -; Transcribed_RNA.
DR EMBL; GDIP01048341; JAM55374.1; -; Transcribed_RNA.
DR EMBL; GDIP01048340; JAM55375.1; -; Transcribed_RNA.
DR EMBL; GDIP01046737; JAM56978.1; -; Transcribed_RNA.
DR EMBL; GDIP01046736; JAM56979.1; -; Transcribed_RNA.
DR EMBL; GDIQ01087387; JAN07350.1; -; Transcribed_RNA.
DR EMBL; GDIQ01085638; JAN09099.1; -; Transcribed_RNA.
DR EMBL; GDIQ01064393; JAN30344.1; -; Transcribed_RNA.
DR EMBL; LRGB01001005; KZS13967.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N8D9Y9; -.
DR STRING; 35525.A0A0N8D9Y9; -.
DR EnsemblMetazoa; XM_045179190.1; XP_045035125.1; LOC116931035.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 5.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR043601; Rspo_Fu-CRD_dom.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF23; FURIN-LIKE PROTEASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF15913; Furin-like_2; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00261; FU; 8.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1198..1218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..622
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 197..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 188
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 227
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 408
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1260 AA; 137279 MW; 76445DC922006C84 CRC64;
MSSRLSYQRT CDTTVMSVIK KTILLVIVYF SYCCASSIVE ESNDLMYNNQ FAVNIPNASE
VLVQLIAEKH GFRSLGQVGS LDGYFLFEHD HVHKRSADPS GLHHEKLVNE PGVVWVAQQF
EKKRYKRDFA SRAGISNFAL GKGSEFPDPF YREQWYLHGG SQEGFDMNVI PAWRKGYSGK
GIVVSILDDG IQTNHPDLAQ NYDPLASSDI NDNDSDPMPR DNGDNKHGTR CAGEVAAVAF
NSYCGVGIAF NASIGGVRML DGTVNDAVEA RALSLNPDHI DIYSASWGPE DDGKTVDGPG
PLAKRAFING IMKGRKGRGS IFVWASGNGG RHDDSCNCDG YTNSIFTLSI SSATQGGFKP
WYLEECSSTL ATTYSSGRPD VDRSIATVDM DGSLRPEFLC TSDHTGTSAS APLAAGICAL
ALEANSNLTW RDMQHLVVFT SRPDPLHDNG WVTNGIGKKV SHKFGYGLMD ASAMVTLAEQ
WTNVPPQHVC QTPADQSDRL IPSGFGQKLE VVVETDACAG SAHEIRFLEH VQCRISLRFA
PRGNLRIRLT SPSGTQSVLL FERPRDVLDS SFDDWPFMSV HFWGERASGR WKLEILNAGV
KRVNKAGILK KWQLVFYGTD TNPIRLRSLQ TPRPTFPNLG GGAATIGRDV HRLTAPPSVA
TPFAPTFKSV GHVPNPTGGQ LFFPGNPGFR PSNFPNTGYP DFLQFAGSQP VTYSAALEAT
QPSNVGIKNN CPNFSLDGNC VDACPPTGYY VSPEMVCLNC HSSCRNCTGA EPHQCLSCAP
QFSQIIDKNL CVEHCPDGYH MDETKMMCIP CQPQCNTCNS ALECSSCEFR FVIHDGQCLP
SCLPGYYETD DYACAPCDTS CSTCRGPHQD HCVTCADSFS EFNGSCIQRC PEGFWSHGLS
GSKQCLPCPP GCEACSLKEN GFDLVCSRCA DQWVLDVSTL LCLNPSANIC PEGEYVVEGK
CYPCHGSCSE CSGSSSSQCT HCSNRTMHLG SCLESCPQGT FVEAGSVDSR HIEFCRPCPH
ACAQCDSMDH CTECLGALHL QNGRCLASCE DGYYSDRGVC VRCHGSCASC SGPLATDCTR
CANSFSWLQH HCLSQCHLGH YNISLGSLIA TEFQTPSKMN QFLCARCHAS CQMCEVSPLN
CLSCSDGFVW NNSTCIPASV EARIFEIPLV EFVKESEGRG IRAKDNVEPG HFISASHWLF
GVAASFIAGL IVVLAIQVKS RSKKYSRVPL SSSENDHETG HEKLLFASDE DESDNTYPKV
//
