ID A0A0P0MGH1_9BURK Unreviewed; 703 AA.
AC A0A0P0MGH1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Fatty acid oxidation complex subunit alpha {ECO:0000313|EMBL:ALK92197.1};
GN Name=fadB_1 {ECO:0000313|EMBL:ALK92197.1};
GN ORFNames=L103DPR2_01799 {ECO:0000313|EMBL:ALK92197.1};
OS Limnohabitans sp. 103DPR2.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Limnohabitans.
OX NCBI_TaxID=1678129 {ECO:0000313|EMBL:ALK92197.1, ECO:0000313|Proteomes:UP000063254};
RN [1] {ECO:0000313|EMBL:ALK92197.1, ECO:0000313|Proteomes:UP000063254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=103DPR2 {ECO:0000313|EMBL:ALK92197.1,
RC ECO:0000313|Proteomes:UP000063254};
RA Ahn J.-H., Kim S.B.;
RT "Limnohabitans sp. 2 strains.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP011834; ALK92197.1; -; Genomic_DNA.
DR RefSeq; WP_055360777.1; NZ_CP011834.1.
DR AlphaFoldDB; A0A0P0MGH1; -.
DR STRING; 1678129.L103DPR2_01799; -.
DR KEGG; lim:L103DPR2_01799; -.
DR PATRIC; fig|1678129.3.peg.1792; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000063254; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000063254}.
FT DOMAIN 303..479
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 484..576
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 612..700
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 703 AA; 75694 MW; 066861E7A75E7EB2 CRC64;
MTAEYKVIGD VAVITMSNPP VNGLGLATRV GITNGLTQAN SDAAVKSIII TGAGNAFSGG
ADINEFGSPK AIQEPNLLSV IRACENSAKP VLAAVHSVAM GGGLELALGC HYRIAAPGCK
VALPEVKLGL IPGAGGTQRL PRVLGVEPAL NMIVSGEPIN SEMLAMLPGQ KLFDRMATSA
ESLAAEAMAY AKELAAQHAD GSALPLVRNL PCKHPQGDAY FQFARNMVKG MAKNYPAPPK
CVDAVEAATK KKFEDGMVFE REIFTNLMWT PECRALRHIF MADRAASKIP DVPSDTPKRT
IASVAVIGAG TMGGGISMNF LNAGIPVKML EMKQEALDRG VATIRKNYEA QVKKGKLKQD
KYEQRMALLT TTLSYDDIGS ADLVIEAVFE EMGVKEAVFK KLDEVMKPGA ILASNTSTLD
VNKIASFTKR PEDVVGMHFF SPANVMKLLE VIRGAKTSKE VLATVMALGK KIKKTAVVSG
VCDGFIGNRM IEQYSRQAGF LIEEGCTPAQ VDKAVEKFGF AMGPFRMGDL AGNDIGWAIR
KRRNVERPGM KYSKTADLLC EMGRFGQKTG AGWYDYQAGK RDAIPSALVV EMIEKHRAAE
GITPRKISDE EIVQRLVFSL VNEAAHILEE GIASKASDID MVYLTGYGFP IFRGGPMLYA
DQVGLFNVAE AMKRFAKNPR DDAAFWQPAP LLARLVADGK TFN
//