ID A0A0P1FZ10_THAGE Unreviewed; 710 AA.
AC A0A0P1FZ10;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=GTP pyrophosphokinase rsh {ECO:0000256|ARBA:ARBA00014315};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
GN Name=rsh {ECO:0000313|EMBL:CUH66287.1};
GN ORFNames=TG4357_02349 {ECO:0000313|EMBL:CUH66287.1};
OS Thalassovita gelatinovora (Thalassobius gelatinovorus).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Thalassovita.
OX NCBI_TaxID=53501 {ECO:0000313|EMBL:CUH66287.1, ECO:0000313|Proteomes:UP000051587};
RN [1] {ECO:0000313|EMBL:CUH66287.1, ECO:0000313|Proteomes:UP000051587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 4357 {ECO:0000313|EMBL:CUH66287.1,
RC ECO:0000313|Proteomes:UP000051587};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; CYSA01000023; CUH66287.1; -; Genomic_DNA.
DR RefSeq; WP_058263087.1; NZ_FOFW01000004.1.
DR AlphaFoldDB; A0A0P1FZ10; -.
DR STRING; 53501.SAMN04488043_10480; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000051587; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 2.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:CUH66287.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051587};
KW Transferase {ECO:0000313|EMBL:CUH66287.1}.
FT DOMAIN 45..144
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 382..447
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 627..701
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 710 AA; 79760 MW; 4813FEE37CD252BE CRC64;
MIAVDDLIAL VCNYNPKTNE NLLREAYAFG LAMHEGQFRH SGEPYFTHPV AVAAILTEQR
LDDATIVTAL LHDTVEDTKA SYSEVEKRFG KEIADLVDGV TKLTNLQLSS SETKQAENFR
KLFMAMSKDL RVILVKLADR LHNMRTIKAM RPDKQSQKAR ETMEIYAPLA GRMGMQSMRE
ELEDLAFKVL NPEARASIMR RFVMLQNETG DVIHRITGDM RQELDEVGID AQVFGRAKKP
YSIWRKMSEK DVGFSRLSDI YGFRVITNSE DDCYRALGVI HQRWRAVPGR FKDYISQPKS
NGYRSIHTTV SGRDGKRVEV QIRTRQMHDV AETGVAAHWS YRDGVRAMNP FAVDPAKWLA
GLTEQFNAEE DHDAFLEAVK LEMYTDKVFC FTPKGEVVKL PKGATPIDFA YAIHTRIGNA
CVGAKIDGMR VPLWTRVKNG QSIEIITAEG QTPQATWLDI ATTGKARTAI RRALREVDRE
RFSKLGRELA RSAFDHVGKK ATDKALETAA RNLRLEDTDM LLALLGSAEL TTRDVLHAVY
PELSEAESDD IELRGAVVGL SHDQHFTIAR CCQPLPGERI VGISHRGKGV IVHAIDCEAL
ANYEDQPNRW MDLHWHAGKH PAIHATTLNV TIGNDAGVLG RICTLIGEQK ANIADLVFVD
RKPDFFRLLI EIELRDAEHL HSVMSALEAE SDVAAVQRHR DPTRANMQAG
//
