ID   A0A0P1GRV0_9RHOB        Unreviewed;       499 AA.
AC   A0A0P1GRV0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE            EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN   Name=mmsA {ECO:0000313|EMBL:CUH85410.1};
GN   ORFNames=TM5383_02643 {ECO:0000313|EMBL:CUH85410.1};
OS   Thalassovita mediterranea.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Thalassovita.
OX   NCBI_TaxID=340021 {ECO:0000313|EMBL:CUH85410.1, ECO:0000313|Proteomes:UP000051681};
RN   [1] {ECO:0000313|EMBL:CUH85410.1, ECO:0000313|Proteomes:UP000051681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8383 {ECO:0000313|EMBL:CUH85410.1,
RC   ECO:0000313|Proteomes:UP000051681};
RG   Swine Surveillance;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CYSF01000014; CUH85410.1; -; Genomic_DNA.
DR   RefSeq; WP_058319490.1; NZ_FTNX01000016.1.
DR   AlphaFoldDB; A0A0P1GRV0; -.
DR   STRING; 340021.TM5383_02643; -.
DR   OrthoDB; 9812625at2; -.
DR   Proteomes; UP000051681; Unassembled WGS sequence.
DR   GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR   CDD; cd07085; ALDH_F6_MMSDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR010061; MeMal-semiAld_DH.
DR   NCBIfam; TIGR01722; MMSDH; 1.
DR   PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CUH85410.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051681}.
FT   DOMAIN          16..479
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   499 AA;  53833 MW;  D76C9C4B6AACB267 CRC64;
     MQEIMNYVDG QMVPGTSGRF TENSNPATGE PASRVPLASK EEMDAIIEKA AAAQVKWAAT
     NPQRRARVMM KFGDLINQHM DELAELVSRE HGKTLPDARG DVQRGLEVVE VCMGAPHMLK
     GEYMNDGGPG IDLYSMRQPL GVVAGITPFN FPAMIPLWKI APAIVSGNAM ILKPSERCPS
     TSLRLAELLK EAGLPDGVLQ VVNGDKEAVD AILDNETIQA VGFVGSTPIA QYIYGRAATN
     GKRAQCFGGA KNHMIIMPDA DLDKAADALV GAGFGAAGER CMAISVAVPV GKETADALRE
     RLIPRIEALK VGPYTSEEDV DYGPVITAQA KDRINGLITS GVEQGADLVT DGRGFSLQGY
     ENGHFIGPTY FDNVTTDMDI YKEEIFGPVL SQVRMDTYED ALNLIIDNDY GNGTAIYTAD
     GDTARDFANK VNVGMVGINF PIPVPLSYFT FGGWKKSAFG DLNQYGPDAL RFYTKTKTVT
     ARWFSGIKEG GEFAFKAMD
//