ID A0A0P5YGL1_9CRUS Unreviewed; 1413 AA.
AC A0A0P5YGL1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=ATP-dependent RNA helicase YTHDC2 {ECO:0000313|EMBL:JAM45683.1, ECO:0000313|EMBL:KZS03203.1};
GN ORFNames=APZ42_034049 {ECO:0000313|EMBL:KZS03203.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAM45683.1};
RN [1] {ECO:0000313|EMBL:JAM45683.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT "Daphnia magna gene sets from two clonal populations assembled and
RT annotated with EvidentialGene.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAM45683.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KZS03203.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS03203.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS03203.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GDIP01058032; JAM45683.1; -; Transcribed_RNA.
DR EMBL; LRGB01003325; KZS03203.1; -; Genomic_DNA.
DR STRING; 35525.A0A0P5YGL1; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:JAM45683.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 19..83
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 174..340
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 452..478
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 535..707
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 991..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1017
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1413 AA; 159502 MW; F8E6021BE9C4942E CRC64;
MAFARNKNGR GNSKHHIYES VKKGLDTLLK SFRDDDSSTE YTFSSTLSTE ERAYIHACAP
TMGMISRSQG KGSERKLTVK KIAIFAKNQI SKLNIHPNTV ARATQLLQEF PLTAEELLDV
LPLENQATRC TTDKQTHADC IKYHMPIIPQ PLKASALIAE RKSLPTWSHR EEILNMISKN
KVVMITGDTG SGKTTQVPQY LLELFSERNE PVRIICTQPR RIAAISVAER VANERGEQLG
GTVGYQIRLE SRMSSKTALM FCTTGILLRT LMYQEGNLER VTHLIIDEVH ERDRFVDFLL
GVLKSRLPRL PNLRLILMSA ALDISVFSNY FSSCPVMHVQ GKCFPVTEYF LEDVLELTDH
LGHSSPLEIG VWEESEIKST ETKIVGISRE GQAPRTSKLE KNNPCVLDSG ARLTFDCWIQ
EAFIIENADA MEKLCKAVMR THLPVNYRHS QTRLSPLMVA AARGRLDLVN SFLQFGADPA
QTAGQWTAAK LARSMHHHTV ADFLEKYQSE KAESLLRIYK DRHDEEAVNV DLVLDVLHLI
EQQSSEGAVL IFLPGYEEIM NIRDRIMYND SRFAASGKFE VYTLHSSMQS GDQRRVFFRP
PSGKRKIVLS TNLAETSITI DDIVFVIDTG KVKVKSFDAV TGVSALKAEW VPQASAIQRK
GRAGRCREGI CYHLYSRQRY ELFEKYQIPE IFRVPLEELC LQSKNLAPTG FSIAEFIGQV
PEAPKLHVIQ RAVKMLQWMD ALDPWENVTD LGRLLLELPV EPRAGKMLLT ATVLHCLDPV
LTIVCCLSHR DPFLLPADPN EKKVAAARKL ELAAGTLSDH MAMLRAFNLW LGARGFPRKE
RDFCHRYFLS SATMEIIHQL RIQILDQLRK SGFVRSLQEL NRNASSWVAI KACILSGLYP
QVARACGSGK LTTRREPSVR LHMTSALLGE NGNASQKKAI SQLPSKWMVY EEISRYGGLV
ASLRCVTLVN TVALAIFGGH CRLSSESLKD PVLSSESENG DDDDDDWTTD DASEESEDID
DALLKELSEG LHDLELAEKF SHSPLPDERN FKQKKKNISK AKSEFHLDEW ICLKMETNAA
HHLFAIRQKW QALFARRMRD PIGAELEGDK QVLDALLSIL SKEEEASGLP PSPEFLGIAE
MRRLHKSDDF GIYRQPNSRP NNINPVLESK NNYMPNPRLH SMPNSWRSNQ RSTIVSDDNF
DQNSRPNSAR NANGPYHMNR IDPFPKGFKG KDLGNLRYKT GNADMNFMTR SSVPQSGGNL
ANQERGQWSR NGTNRATHIH DNGASASNKE WRNEVDVGNK NGFNSKAKPK NQFTAGYGNA
NQTPNFPRDR LPPRLERRAG KIPSESQTNK HQPDQSKRIV PKENAQGYFQ RQAKERGTDV
LIQEPNANIQ LSKRRKRPQK RKETNVALPP IPF
//
