ID A0A0P7YF40_9BACT Unreviewed; 668 AA.
AC A0A0P7YF40;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=2-oxoisovalerate dehydrogenase E1 component {ECO:0000313|EMBL:KPQ13164.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:KPQ13164.1};
GN Name=bkdA {ECO:0000313|EMBL:KPQ13164.1};
GN ORFNames=HLUCCX10_13880 {ECO:0000313|EMBL:KPQ13164.1};
OS Algoriphagus marincola HL-49.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Algoriphagus.
OX NCBI_TaxID=1305737 {ECO:0000313|EMBL:KPQ13164.1, ECO:0000313|Proteomes:UP000050421};
RN [1] {ECO:0000313|EMBL:KPQ13164.1, ECO:0000313|Proteomes:UP000050421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HL-49 {ECO:0000313|EMBL:KPQ13164.1};
RA Nelson W.C., Romine M.F., Lindemann S.R.;
RT "Identification and resolution of microdiversity through metagenomic
RT sequencing of parallel consortia.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPQ13164.1}.
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DR EMBL; LJXT01000101; KPQ13164.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7YF40; -.
DR STRING; 1305737.GCA_000526355_03757; -.
DR PATRIC; fig|1305737.6.peg.3485; -.
DR eggNOG; COG0022; Bacteria.
DR eggNOG; COG1071; Bacteria.
DR OrthoDB; 9769337at2; -.
DR Proteomes; UP000050421; Unassembled WGS sequence.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KPQ13164.1}.
FT DOMAIN 352..525
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 668 AA; 74838 MW; 26591BC709CB24C7 CRC64;
MEIATTPSKE LNFDRKKLST TKLLELYEAL IIPRRIEEKM LILLRQGRIS KWFSGWGQEA
VSVGAVQALM KDEFILPMHR NLGIFTGRKI PLTKLFAQFQ GKKSGFTKGR DRSFHFGSVE
HHIVGMISHL GPQLAIADGV ALANQLSKEK KVTLVFSGDG ASSEGDFHEG LNVAAVWKLP
VIFVIEHNGY GLSTPNQEQF AFKNFTDKGP GYGMETVRVE GNNILDVYQT ISDLAKDIRK
NPRPVLVEAI TFRMRGHEEA SGTKYVPKQV MEEWSKLDPV ENYELYLESL GVLDEKNKEL
INHKVRKAIT EAWEIAFAEE AILPDLAEEL ADVYAPFDQE VVKPSYGQNC EKRFVDAISD
GLRQSMEKFP KLVLMGQDIA EYGGVFKITD GFVKEFGADR VRNTPLCESA IIGTGLGLSV
KGYKAMVEMQ FADFVSVGFN QIVNNLAKIH YRWGQKADLV IRMPTGAGVA AGPFHSQSNE
AWFFHTPGLK IVYPSNPYDA KGLLNAAIED PNPYLYFEHK ALYRSLSEEI PDDYYTVEIG
KAKLISEGEQ VSIITYGMGV HWAKKATEEL GLSADILDLR TLLPWDQEAV KSTVKKTGKV
IFLQEDCLTG GIGAEICAWI SEHCFEYLDA PVMREGSLDT PVPFAPNLEK QFLPEGRFRE
KLKNLVDF
//
