ID A0A0P8A2E7_9EURY Unreviewed; 206 AA.
AC A0A0P8A2E7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Hef nuclease {ECO:0000313|EMBL:KPQ42236.1};
GN ORFNames=MPEBLZ_03216 {ECO:0000313|EMBL:KPQ42236.1};
OS Candidatus Methanoperedens sp. BLZ1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Candidatus Methanoperedenaceae; Methanoperedens.
OX NCBI_TaxID=1719120 {ECO:0000313|EMBL:KPQ42236.1, ECO:0000313|Proteomes:UP000050360};
RN [1] {ECO:0000313|EMBL:KPQ42236.1, ECO:0000313|Proteomes:UP000050360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Arshad A., Speth D.R., De Graaf R.M., Op Den Camp H.J., Jetten M.S.,
RA Welte C.U.;
RT "A metagenomics-based metabolic model of nitrate-dependent anaerobic
RT oxidation of methane by Methanoperedens-like archaea.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPQ42236.1}.
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DR EMBL; LKCM01000252; KPQ42236.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P8A2E7; -.
DR Proteomes; UP000050360; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd20075; XPF_nuclease_XPF_arch; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR10150; DNA REPAIR ENDONUCLEASE XPF; 1.
DR PANTHER; PTHR10150:SF0; DNA REPAIR ENDONUCLEASE XPF; 1.
DR Pfam; PF02732; ERCC4; 1.
DR Pfam; PF12826; HHH_2; 1.
DR SMART; SM00891; ERCC4; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722}.
FT DOMAIN 1..74
FT /note="ERCC4"
FT /evidence="ECO:0000259|SMART:SM00891"
FT DOMAIN 147..166
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 179..198
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
SQ SEQUENCE 206 AA; 23244 MW; 4309328D7D524D91 CRC64;
MRSRVPEALV KLGAEIEIST LKTGDYVVSD RVAFERKTVD DVFATLIERR ELFSQLTDLA
KSYRKPILII EGEDIFFFSG RRMNPKAIQG FLNSIALMRI PTIYTLNEAE TAQVITMIAA
KEQIDKTRSF NLHGKRSRLS QSKAKEYIVS SLPGIGQVAA RNLLKHFGSV ENVMTAPLEE
LMNVERVGYR TAKRIRELSG GRYGSE
//
