ID A0A0P8XJ73_DROAN Unreviewed; 8397 AA.
AC A0A0P8XJ73;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Uncharacterized protein, isoform E {ECO:0000313|EMBL:KPU74927.1};
GN Name=Dana\GF19006 {ECO:0000313|EMBL:KPU74927.1};
GN Synonyms=dana_GLEANR_20542 {ECO:0000313|EMBL:KPU74927.1};
GN ORFNames=GF19006 {ECO:0000313|EMBL:KPU74927.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU74927.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU74927.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; CH902646; KPU74927.1; -; Genomic_DNA.
DR RefSeq; XP_014759331.1; XM_014903845.1.
DR EnsemblMetazoa; FBtr0382573; FBpp0342777; FBgn0096018.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 39.
DR CDD; cd00096; Ig; 3.
DR CDD; cd05748; Ig_Titin_like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 76.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340:SF24; -; 1.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR Pfam; PF00041; fn3; 39.
DR Pfam; PF07679; I-set; 34.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 39.
DR SMART; SM00409; IG; 35.
DR SMART; SM00408; IGc2; 27.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 21.
DR SUPFAM; SSF48726; Immunoglobulin; 37.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 39.
DR PROSITE; PS50835; IG_LIKE; 25.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 122..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 226..321
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..423
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 428..516
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1198..1290
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1293..1377
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1571..1668
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1671..1769
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1773..1863
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1871..1966
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1972..2067
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2169..2266
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2272..2367
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2371..2463
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2471..2566
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2572..2667
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2671..2760
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2768..2862
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2869..2964
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2968..3058
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3066..3159
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3165..3260
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3264..3353
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3357..3454
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3460..3555
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3559..3649
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3657..3750
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3756..3855
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3956..4049
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4055..4150
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4154..4245
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4251..4344
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4350..4443
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4447..4537
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4545..4640
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4646..4740
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4842..4935
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4941..5035
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5134..5228
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5234..5329
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5428..5526
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5532..5627
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5631..5722
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5729..5823
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5829..5923
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5929..6024
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6018..6115
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6124..6218
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6224..6320
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6420..6514
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6520..6615
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6621..6716
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6722..6800
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6914..7009
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7015..7110
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7115..7204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7209..7302
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7307..7400
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 7457..7712
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 7780..7868
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7905..7980
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8096..8184
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8204..8294
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8303..8377
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 623..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2651..2672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3440..3464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4428..4447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5817..5840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5926..5951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6204..6228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8022..8080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8027..8063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 7486
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 8397 AA; 940459 MW; E546EB62081EE30B CRC64;
MGVAEDFAPS FIKKPQLHQE DDGNRLIFEC QILSSPKPDI EWFRSDNKLV EDERTKFKIQ
PDGNNNYTVV LELDDVVEAD AGLYKVKAKN KSGEVSASIN LNFTQGMFSL HENEGQIDGF
APTFAKKPAI RQEEDGKRLL FECRVNADPI PIIKWVHNGT DVKESSRHKL TIDKDGHSYF
ATLEIMNVTV EDAGKYKVNA KNELGESNAT ISLNFDSASD VNGFAPSFIE KPRIIPNESG
TLITMKCKCK AKPEPTVTWY RGQEVVEKNQ KIKINIIVVA EDTYELTLEI KDPGASDGGT
YRCNVKNEFG ESNANLNLNI EAEPELEGEG PTFIEKPRIV SENNGKLVIM ECKVKADPKP
DIIWYRNGMA IQEINKIKMS MEQRGDQYYI KLELLDPQLD DSGIYKCNIK NSLGELNANL
TLNIEIVPVI KEKPKIIKII KKRSVVIECT VASKFQPKCT WYKEANVVKE STRHVYLVEK
IKDGEFAVKL EINDVEESDK GAYKVVASNE KGEAVSQVVN LIDIPEEDRK PSKPEILKKL
VDQKVTESKM FELLIKLTQS DRKCKVEWYK GNTLLRETKD ITTTFDGTIA RLTFSTAKSE
HTSNYKVIVI NEVGKDESSC KVTVEKKDKK KDEKPKNNDA SDANKELKPQ AAEEKILKKA
ERKASIISVK EDDSLEVRRQ SIINCKEETS IEDSKIEEVR KSSLVVQESK TGSRRSSIIE
KNSLEPIEAQ KPSEDLPHLR KASIAQPKEE SKPEAPKAKT KPKAKSKPKY EELPEIPDYE
RPVLEKYEKS EFKPSDFGRD VEIPSKMEKP ILDGNKKEPQ PESPKNDLLK KTAIIEKTPE
EKKELKIGKG KLAYEDDGQD GVSLKPVIIE PQEEKPKMTK IQQPAAGEPP KIEVIREKRP
SLAPEPPSRR GSLIPPADMG RRPSLIINDE RRRPSIDVRR PSVQDLEDLI NKPSTPLRDV
GDGGPPSIVD VQESYSVVED STAYLTVGVE GSPAPTFKFY KGVSEILEGG RYKFLTDGQT
NTITLCMRKC KPNDEGKYKI VVSNIHGEDS AEMQLYVSDS SGMDFRAMLK KRRYQKWDKD
EQDPNWGDLK ETEKPLPALK KVERKVESFL SPLIDQFAKE GKDKKVIFEA RFSKPNCKPK
WLFRKDEVFT GSKFKFKQEN DTYQLIIMTP KVEDTGKYTI EIGGVSSTAF LNVEEADPTY
TFTKTLKKKL EGFTEHETTL ECAVSSSMAN VHWFKDNTKI ESDDPRYLIS KDINGNLKLI
IKESLIEDSG LYRCQLDKQS DKTECNLRVV EYPYKFVKVL KSQQCVEKDT VTLACEIDDA
RGEVQWFRND EEIKADKRIQ IIKDGRKRKL VIKDCKVTDA GRFKCTTNAD KTEAEIIINY
QNRFNKKLKD TDAVEREKLV LDIELQDQTA PCNWKFNGDP IVPNERIEIK NLGGGKHQII
FNNLEMSDEG EIECESGQIT SKCHLSVRKG ESRPNIDCPD EFTGPISAPV VIEVPFKVSG
TKQSPVEAKL FKDGKPLPVK DVDVCIADDK VIFKIKKPSR DLSGPYQIKL SNGQGEDSKD
VHIICQDVPQ PPQDVDITDV YQTSCIVNFK PPTDDGGTPI IKYLIERQDI SKKQGWEPVV
EVLPSEPLVK KIDDLVPKKQ YRFRLRAVNK IGPSDPATFK SSILAKDPWD EPGKPQSVDL
IDWDKDHADL KWEAPENDGG DLITSYILEY KEKFSNDWVT SKEVDGQTRA ATVDGLKEGQ
QYEFRVRAVN RAGPGEPSDK TKSIIAKCRF VKPFLVGDGL KNITVKKGQT IRYDIKYDGE
PEPTATWLKG HDNIKFDNQR ISLEQLERNS SITVKKAVRK DTGRYKLVLS NSSGTIESEA
QVVVLDRPLA PGGPLEPDEI RANHIKMKWK HPEDDGGCEI TGYTLERMDE ETGRWIPAGE
VGPNENSFDF KGLTPNKKYK FRVKAINKEG ESEPLETSDA ILAKNPYDPP SPPSQPIIDD
YDNKSVSLKW NRPPSDGGRP ITHYVVEMKD KFSPTWSEVA QTEDPTPKCS VEGLKEKMIY
QFRVRAVNKA GASEPSQPTD NHLCKHKNLK PQIDRSTFKR VTIKSGRTHK WSVDVIGEPV
PTLCWSWRDD IPLNNGDRIK IENVDYHTDF AITNALRKDS GFYTLKAENC NGIDRETVEL
VVLGKPSSPK GPLAVGDVSA TGCKLQWKKP DDDGGVPIKE YVVEKMDTAT GKWIRVGRSP
GEKEPPSFNV TGLSPGSEYM FRVSAVNEEG ESEPLTSLVG VVAKDPFDEP NKPGAPEVID
HDNESVSLKW MPPNNDGGAP IQKYIIEKKD KNKPEWEKAI EVSGDKLEAK VGGLQEYGEY
QFRVIAVNKA GLSPPSDASV PQIVKYKKLK PRIDRTNLKP LLIRAGKPIK YDINVRGEPA
PTITWYQNDL ELKPNELPNN SEIKNIPYNT KISILDAVRK NTGTYKIKAV NEHGEDEATV
EVNILGPPGK PMGPLAVTDI TKDSCKLKWK KPNDDGGVPI TAYQVEKFDK KQGRWVPVGR
SSGNDTEFDV KGLQEGHEYQ FRVRAINEEG ESEPLETDGS IIAKNPYDAA SKPGTPIIDD
YDEHMVKLRW EPPKSDGGVP IVGYIIEKKD KFSPIWDEVL TTNSPAPEAV VKELTEGNVY
QFRVRAVNKA GASEPSDATG HHLSKPKNLK PSINREKMNS IKVRAGQAVK FDIDVKGEPA
PSLTWIFKEK ELLHTGKVRL ENEDYNTKLT LLDTSRKDSG QYRLRAENIN GVDEADVEVI
ILDKPSKPEG PLEVSAVHKE GCKLRWKKPK DDGGVPLTGY VVEKMDTATG KWVPAGSVDS
EKTDIEIKGL DPNHRYQFRV KAINEEGESE SLETDSAITA KNPFDVSAPP GLPELEDWDE
NHVKLKWEPP IRDGGSPISC YIVEVMDKDT GEFVKALETD SPICKGIVKK LDEGQQYKFR
VRAVNQAGPS DPSEQTNWHT AKPRYLKPHI DRTNLKPVIV KTGLSISLDI IIKGEPAPKV
QWLFNGNPLI NQKDGVQIDN IDYNTKFFVM RAERSQSGKY TIKAINEVGE DEAELEISVL
GKPAKPEGPL HVNDVTKHSC KLKWNKPKDD GGAPIDYYEI EKLDPHTSQW LPCGKSTEPE
AKVIGLQEGK QYKFRVRAVN KEGESEDLET EKPIIAKNPF DEPDKPGRPD PTNWDKDFVD
LAWDPPKNDG GAPIQKYIIQ MRDKSGRSWV DAATIAGDKT KGTVTGVQEG HEYEFRVVAV
NKAGPSDPSD VSKSVIAKPR HLKPHIDRKN LQKKIMRNGQ LLHMDANVKA EPPAKITWVY
NGAEIKNSDK IKIENEDYKT TFVIPKVKRT DCGIYTVTAK NDSGSDTVQV ELEVLCKPSK
PKGPIAVSAV LAESVHLKWD KPEDDGGEPI EHYIVERMDT ETGRWVPVQT TKTPEADVTG
LTEGKEYLFR VKAVNSEGES EPLVSDVPTK AKNPFDPADT PGKPQITDWA ANFCDLKWRA
PEDDGGAPIT SYIIEKKDPS TGKWQKAFES NTPDCKARVN DLIEGKKYQF RVKAVNKAGQ
SKPSEPSDQL IAKDRFAPPK IDRTHIKDVT IKAGQPIRYD IKVSGEPPAT KAWLHNKARL
NSDDTDYNID IESYRTKLAV PFAKRLHSGK YTLKAENESG RDEASFEVIV LDKPGTPEGP
LRVSDVHKEG CMLKWNPPLD DGGLPIEYYI VEKMDTETGR WLSSGRFKEP LAEVCNLEPG
HEYKFRVLAV NTEGESNPLI GEQPIIAKNP FDEPGKPGIP EASDWDKNHV DLVWRPPIND
GGSPISSYIV EKREKGTDKW IKGAEVTAPE LGEECRASVN NLDENCEYEF RVKAVNAAGP
GEPSDSSKFV ITKPRKLGPK IDRRNIRTYN FRAGEPIFLD INISGEPAPD VTWQQNNKSV
QSTSEYHIEN IPYNTKYINN NPNRKDTGLY KIIALNLYGQ DQVELQINII SKPGKPEGPL
EVSEIYKDGC KLKWKKPKDD GGEPIECYLI EKFDSDTGIW LPVGKTEVPE YNVDGLVSGN
EYQFRVKAIN KEGESEPLET FGSIIAKDPF TVPSKPGVPE PTDWTANRVE LSWLEPANDG
GSPITGYLIE VKDKYSPLWE KSLETSSPTP IATIPGLIEG NEYQFRVVAL NKGGQSEPSD
PSKTFIAKPR YLAPKIDRRN LRDVTISSGT ALKLDANITG EPVPKVEWKL SNYPLQSSKN
VTIETPDYYT KLVIRPTQRS DSGEYLVTAT NSSGKDSVLI NVVITDKPTP PKGPLQISDV
HKEGCHLKWK RPIDDGGTPI EYFQIDKLDS ETGCWVPCCR STEPQVDVSG LTPGNEYRFR
VSAVNSEGES LPLLGEDAVV AKNPFDEPGK PENLRATDWD KDHIDLAWTP PLADGGSPII
GFIIEKKDKY GKWEKAVEVP ANQYEARVPD LTEGQAYEFR VSAVNAAGPG EPSDATHSLT
AKSRNKPPVI DRSNLIEVRI KAGQGFGFDC KVSGEPAPKT KWLLKNKEIH TKENLKITHI
DYNTKLKVNG ATRSDSGLYT VEAENENGKD SANVKVTVID KPSPPNGPLK VTDVAAEGCT
LHWNPPDDDG GQPIDSYSLE KLDEVTGRWI PAGETDSPIT NIRIKGLTPG HKYKFRVRAK
NRQGVSDPLT TPHVIEAKNP YDEPTKPGIP IITDFDKDFV DLEWTRPDSD GGSPITGYII
EKRDKYSPNF EQIVEINGDI TNGHVPGLIE GVKYEFRVRA VNKAGLGTPS DSTEPHLARS
KNLPPNIDRN FMTDIKIKAG NVFEFNVPVS GEPIPSKEWS HDDSMVINTD RVKITNYNDR
TKLRTIDAKR SDTGSYTLVA RNINGVDKHT VKLIVLDIPT APEGPLRHND VSKSSAMLSW
RPPRDDGGSE ITHYVVEKMD NEAMRWIPVG ESSSTEIRAD NLIENHEYNF RVRAVNKQGQ
SQPLVTSQLI TAKDPYSHPD KPGQPIAVDW GKDYVQLEWT APKKDNGAPI SSFIVEKRPK
FGLWERALMV PSNELTAYIP ELTDGGEYEF RIIAVNRAGP SDPSDPSTPI ICKPRFLAPY
FDKNSLNDIT VHAGKRLGWN LPIEASPKPS IKWLHNGKET ASTRGESSLF QNELTFEIAS
AIRGDEGRYT LILKNEHGCF DASAHVTVLD RPSPPKGPVD ITKITRDGCH LAWNVPEDDG
GSPILHYVVE KMDLSRGTWS DAGMSTHPVH DVSRLVHRKE YLFRVKAVNA VGESEPMEAA
NSIIAKNEFD EPDAPGKPNI IDWDRDHVDL QWAEPKNDGG APLEEYIVQK KEKGYPYWTN
VLHVPPNQNN AKVSELTEGQ EYEFRVIAVN QAGQSEPSEP SDLIKAKARY LAPKILSPLR
EIRIKAGLIF HIDIDFIGEP APEAIWTHNN NPLISNDKST ITSIGHHTVV HTVNCQRTNS
GIYHLLLRND SGIDEGSFEL IVLDRPGPPD GPMQFEEITA NSVTVSWKPP KDNGGSEISS
YIIEKRDLTH GGGWVPAVNY VNAKYNHAVV PRLLEGTKYE FRVMAENLQG RSDPLTSDHP
IIAKNQYTVP GIPGKPEIAD SDKDHISIKW KQPISNGGNS IIGYDIERRD VNTGRWIKIN
GQPIPITEYQ DDRVSTNHQY QYRVSAINAA GNSKPSEPSS IFHARPLREK PKLYLDGLVG
KRLKVRAGEP VNITIPISGA PTPTIEWKKD SQNLAEGKRV SSDTNSERSV FRIDDSRRQD
SGKYSIIASN DFGIDKADIE IIVVDKPTPP EGPLCYTKTA PDHISLQWNP PKDDGGSEIT
GYVIEFSEFG TDDWKPVPGY CPKTNYTVKG LLEGRKYIFR VRAENIYGSS DALEGNPVIS
KSPFDPPGPP SQPSITAYSP NSASLEWHPP DYCGGKPISG YIVERRERGG EWIKCNNYPT
PNASYTVPDL RDGVRYEFRV TAVNEAGPGQ PSKPSDSVTA KLQCYCPDPP EPPKPDRISK
DSVTLSWRPP RNDGKSKIKG YYVEMRPKNG NDWKPVNELP INSTVYVVPH LKEGEEYLFR
VIAENDVGRS SPSKPSQPIM IEEQPNKPSM ELGSVRDIVC RAGDDFSIHV PYMAFPKPNA
SWYSNDTILD DDNRVHQHLT DDAASIVVKN SNRCDSGQYR LQLKNPSGFD TATINVKVLD
RPGPPSNLRA DEFSGDSLTL YWNPPKDDGG SPIQNYIIEK KEAHSPTWNK VSSYCTVPFV
RIRNLTINKE YDFRVIAENK YGQSDSANTS EPIKARHPFD VPNAPGIPRG IDSSEDSITI
SWSKPKHDGG SPISGYIIEK RLLSDDKWTK AVHALCPDLT CKIPSLIENA EYEFRVAAVN
AAGQSAFSAS SDLIFCRRPP NAPKITSDLS IRDMTVIAGE EFHITVPYNA NPRPTPSWTL
NGIDVAPNDR VHFNTDDYIS VYYNKFAKRC ETGAYTITLT NTKGADTASC HITVVDRPAP
PQGPLNAYDI TPDNCTLAWK TPLDDGGSPI TNYVVEKLDP SGTWVKVSSF VRNTHYDVMG
LEPQHKYHFR VKAENQYGLS DPLVLSDPIV AKHQFTVPDE PGQPKVIDWD SGNVTLIWTR
PTSDGGSRIQ GYQIEYRDIV NDSSWNTYDF LIKDTKYQLY NLANGTEYEF RIKAKNAAGL
SKPSPPSLRF KLKGKVSAPS PPETPQVTKV GKNYVDLKWE KPLRDGGSRI TNYVIERRDI
GGALWVKCND FNVLDTEYTV TSLIEMGDYE FRIFAVNSAG RSEPSLCTMP VKVCEVIGGE
KPEWITRLQN RVVPHGKDCT LKCEAIGKPS PISRWLRNGK EIQMGVSRFS CDSIDGVYRL
HISNVQAGDE GNYTCEATNS LGFVHTTGFL KIGSPPIINK CPKELYLPEG DNTKIKIYYS
GDQPLSVKIT KNNEVISDDN DESHFKFTIF DEYAALFIRD IVKNDAGLYQ IEFTNDSGSA
IGQFDVRITG IPSSPTGPMG VSNINKHSCI VTWRQPAHDG GLRVTHYIVE RKDVASPHWI
TVSSTCKDTS FNVQGLIENQ EYIFRVMAVN ENGMGPPLEG LNPIRAKAPI DPPSPPGIPQ
ILEIGGDFVH LEWTKPESDG GSHIQGYWID KREAGSDTWQ RVNVTICSAT QINCPHLIET
RQYEFQVFAQ NAAGISKASS ASQTVKIVDP KAASPPFVVK PLRDANCIQN HNAQFSCTIS
GIPRPTITWY KGAREITNGA RYHIYSEGDN HFLSINDIFG EDADEYVCRA VNKAGAKSTR
AALVIMTAPK LNVPPRFRDT AYFDKGENVV IKIPFTGFPK PRINWVKEGE NIESGGHYAV
EVKERHAVLI IRDGSRLDSG PYRITAENEL GSDTAIVQVQ ISDRPDPPRF PLIENIGTDS
LSLSWKSPVW DGGSDITNYY VERREHPLAS WIRVGNTRFT LMAVGGLNAG KEYDFRIFAD
NVYGRSEPSN TSTLIKTKEA IKKKPTERKW ELDANGKKVR GKADGQIKDY DSYVFDIYSK
FVPQPVEISQ QSVYDKYDIL EEIGTGAFGV VHRCRERSTG NIFAAKFIPV SHLIERDLIR
REIDVMNQLH HQKLINLHDA FDDDDEMVLI LEFLSGGELF ERITVEGYVM TEAEVINYMR
QICEGLKHMH ERNIIHLDIK PENIMCQTRS STNVKLIDFG LATRLDPNEV VKITTGTAEF
AAPEIVNREP VGFYTDMWST GVLAYVLLSG LSPFAGDNDV QTLKNVKACE WDFDEQSFNN
ISDDGKDFIR KLLVANKEKR MTAHECLLHP WLTGDHSNMT QAITRDRYLA YREKIRRKFE
DFEKYLLPIG RLSEYSSLRK LLMEKYKIHD TVFDRRQAAP RFVIRPSSQF CYEGQSVKFY
CRCIAIATPT LTWTHNNIEL RQSVKFMKRY SGDDYYFIIN RVKLDDRGEY IIRADNHYGS
REEVVFLNVQ PLPKEQPRYR TESTPIRRRD PLPYTFWQEE SESAPSFTFL LRPRVMQARD
TCKLLCCLSG KPVPSVKWYK DGRELSKYEY AMTHSDGVVT MEIIDCKPSD SGKYICKATN
CHGFDETECV VIVEGEWVTP EQAELAHNFL YSGDRKYIEQ PLKPAPPQIV TSRQLTSTSM
QETSETKNDE NSNQSNLSNK KKYAASSLKA PGSPSRSRSA TKELILPPDD SLMFKPEFIV
PLHDLNIHDG EQLVLSCHVK GDPEPQITWS KNGKSISSSD IIDLKYRNGV ATLTINEVFP
EDEGIFTCTA TNSISAVETK CKLTIKALGK NISNLRVASK DNAPKVVSHL ESRYVKDGDA
VTLACRIIGA EHFDVVWLHN NKEIKPSKDF QYSKEANIYR LQIAEIFPED GGTYTCEAFN
DVGESFSSCT INVSVPGDEP KHPAFVRFPI SVSIQEGENV IFDCELDSEI LNLIWVKDGK
PIDETLSRYS FTKENNIYSF SVSKCNMDDV GQYQAKAIAR KGESICAFSV NIYNSEL
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