ID A0A0P8YDL9_DROAN Unreviewed; 2240 AA.
AC A0A0P8YDL9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Uncharacterized protein, isoform K {ECO:0000313|EMBL:KPU79598.1};
GN Name=Dana\GF17864 {ECO:0000313|EMBL:KPU79598.1};
GN Synonyms=dana_GLEANR_19126 {ECO:0000313|EMBL:KPU79598.1};
GN ORFNames=GF17864 {ECO:0000313|EMBL:KPU79598.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU79598.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU79598.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; CH902617; KPU79598.1; -; Genomic_DNA.
DR RefSeq; XP_014766653.1; XM_014911167.1.
DR SMR; A0A0P8YDL9; -.
DR EnsemblMetazoa; FBtr0391728; FBpp0351155; FBgn0094882.
DR GeneID; 6500647; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21311; CH_dFLNA-like_rpt1; 1.
DR CDD; cd21315; CH_dFLNA-like_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 20.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF18; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 20.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 20.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 20.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 20.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..150
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 169..272
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 279..377
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 379..477
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 478..574
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 574..665
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 668..764
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 765..853
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 861..959
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 960..1052
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1053..1151
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1152..1247
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1248..1342
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1352..1453
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1453..1545
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1543..1633
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1636..1728
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1726..1826
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1829..1921
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1923..2016
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2018..2109
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2146..2240
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2240 AA; 243024 MW; 5398E1C7BCF78B2C CRC64;
MASRKPNEYY QQAQQQGQPA DQYEENFDED MEAERDLAED AQWKKIQQNT FTRWANEHLK
TIDRSINNLE TDLSDGLRLI ALIEVLSQKR MPKYNKRPTF RSQKLENVSV ALKFLQDEGI
KIVNIDSSDI VDCKLKLILG LIWTLILHYS ISMPMWDGED EKQLNGSGHT PKQRLLNWIH
AKIPDLPINN FTNDWTTGKA VGALVDACAP GLCPDWEMWD AKDAVQNASE AMGLADDWLN
VRQLIKPEEL VNPNVDEQSM MTYLSQYPNS KLKTGAPLRP KTNPNRVRAY GPGIEPIGPV
VGAPANFTVE TFSAGKGAVD VEIQGPNGEI EKADVRFNND KNLTYTVSYI PKAEGPHKVG
VKFSGRDIPK SPFPVKVEGH AGDASKVKVT GPGIQPNGVT IKKPTFFDIL TKDAGRGVPE
VIIIDPANHK TSVAAKVRQL ENDTWRCEYV TALQGLHSVN VFYAGTPIPN SPFPVKVAPL
SDARKVRASG RGLQATGVRV GDDADFKIYT EGAGEGLPEV RVIGPGGMNQ NVMLSKVDGN
TYECHYYPTK EGRYVIMVTF AGQEVPKSPF EIKVGPKKES SIVAYGPGLS SGVIGYPAAF
VVETNGETGA LGFTVAGPSQ AEIECHDNGD GSALVKYLPT AVGEYAVHIL CDNEDIPKSP
FIAQILPRTD FHPELVKSSG PGLEKNGVTI NQPTSFTVDT SKAGNAPLDV VVQDVYGTKL
PVELKNNPDG TKKVTYTPTS GVPHTVEVNY GGVSTPNSPH RVYVGVPVDA ARVQAFGPWL
QPGVHPNVPT HFNVDAREAG DAELKVKIVH EETKLEVPCR IIDNEDNTYS VEVIPPTKGA
YTTTMTYGGQ RVPLGQKVVV EQTVDVSKIK VDGLEPSVIM NAATDFMVDM SNVGSNIDSG
KLSCAIFDPM GHVLPSKIVQ GPTDDIFRIM YTPFEAGRHT IELMYDNIPV PGSPFVVNVK
SGCDPSRCKA YGPGLETGLT NQKNKFTVET KGAGNGGLSL AIEGPSEAKM TCTDNRDGSC
DVDYLATDPG EYDITIRFAD KHIPGSPFRV LVEETVDPTK VKVYGPGIEH GQVRESVPTY
FNVDVAEAGP GRIAVKLTNS EGIPVDNLRV EDKGNSIYAV HYVPPKAGSV LTCQVKFSEV
EVPCSPFVMT VFPKSEATKV KVKGVNEKKK TPASLPAEFE IDTKQAGQAD INVAIKNPKG
KPMQPRLEEV ASGTYVVSFV PDECGTYQCS IKYGDKEIEG SPFKLEAFPT GEAKKCKLVE
QAPKIQPSGS QSHLKVDARE AGDGAVTCKI TNKEGNEIVD IDVIEKDGFF DILYALNDPG
DYDINVKFGG KDIPNGSFSI KAVESIEQYS HSEYIEEHTT KVVQQTTQSE LVNGKSEITY
RSVAFEKLPL PTTGGNVTAE VRMPSGKVDK PVIQDNRDGT VSVKYDPREE GSHELVVKYN
GEPVQGSPFK FHVDSITSGY VTAYGPGLTH GVTGEPANFT ISTKGASAGG LTMAVEGPSK
ADINYHDNKD GTVSVQYLPT APGEYQVSVR FGDKHIKGSP YFAKITGEGR KRNQISVGSC
SEVTMPGDIT DDDLRALNAS IQAPSGLEEP CFLKRMPTGN IGISFTPREI GEHLVSVKRL
GKHINNSPFK VTVCEREVGD AKKVKVSGNG LKEGQTHADN IFSVDTRNAG FGGLSVSIEG
PSKAEIQCTD KDDGTLNISY KPTEPGYYIV NLKFADHHVE GSPFTVKVSG EGSNRKREKI
QRERDAVPIT EIGSQCKLTF KMPGITSFDL AACVTSPSNV TEDAEIQEVE DGLYSVHFVP
KELGVHTVSV RYSEMHIPGS PFQFTVGPLR DSGSHLVKAG GSGLERGIVG EAAEFNVWTR
EAGGGSLAIS VEGPSKADIE FKDRKDGSCD VSYKVTEPGE YRVGLKFNDR HIPDSPFKVY
VSPDAGDAHK LEVQQFPQGN IQADAPYQFM VRKNGAKGEL DAKIVAPSGT DDDCFIQVID
GEMYSVRFYP RENGIHAIHV KFNGVHIPDS PFRIKVGKDV ADPAAVHATG NGLDEVKTGH
KADFIINTCN AGVGTLAVSI DGPSKVAMDC TEVEEGYKVR YTPLLPGEHY ITVKYNNMHI
VGSPFKVNAT GDKLADEGAQ ETSTVIVETV QKVAKGGKNT GVHLPTFKSD ASKVVSKGMG
LKKAYIGKQN QFSISATDAG NNILYVGMYG PRGPCEEFHV KHAGHNNYNV QYLVRDRGQY
VLLIKWGEEH IPGSPFQIDV
//
