ID A0A0Q2UV34_9RHOB Unreviewed; 314 AA.
AC A0A0Q2UV34;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:KQI68112.1};
GN ORFNames=AN189_11920 {ECO:0000313|EMBL:KQI68112.1};
OS Loktanella sp. 3ANDIMAR09.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Loktanella.
OX NCBI_TaxID=1225657 {ECO:0000313|EMBL:KQI68112.1, ECO:0000313|Proteomes:UP000051463};
RN [1] {ECO:0000313|EMBL:KQI68112.1, ECO:0000313|Proteomes:UP000051463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3ANDIMAR09 {ECO:0000313|EMBL:KQI68112.1,
RC ECO:0000313|Proteomes:UP000051463};
RA Mas-Llado M., Nogales B., Bosch R.;
RT "Draft genome sequence of Loktanella sp. 3ANDIMAR09.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQI68112.1}.
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DR EMBL; LJAK01000007; KQI68112.1; -; Genomic_DNA.
DR RefSeq; WP_056036079.1; NZ_LJAK01000007.1.
DR AlphaFoldDB; A0A0Q2UV34; -.
DR STRING; 1225657.AN189_11920; -.
DR PATRIC; fig|1225657.3.peg.2445; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000051463; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000051463}.
FT DOMAIN 5..314
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 108..283
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 314 AA; 33320 MW; DAB845008C1C1C72 CRC64;
MKRLLLTRPF PDATIEAVRP HFDVTISDDG PLSVEAAASA LQEYDAIMCT LGDGFTDMAF
ATPDLRCKML ANFGVGYNHI DVRAAKAAGV TVSNTPGAVT DATADIALTL MLMAARRAGE
GERLVRAGQW TGWEPTQLLG MHLTGKRIGI VGMGRIGQAI ARRAHFGFDM KVIYYNRSVK
DVDFPARQVE ELSGVMSQSD VVVVAVPGGG ENVHLIDADA LAELSDGAIF INIARGDVVD
EASLVAALKS GRISAGLDVY ENEPTVPSEL LGLDNVVLLP HLGTAALEVR EAMGQLAVDN
LIAWDQGDSP PNVV
//
