ID A0A0Q3M6R5_AMAAE Unreviewed; 4346 AA.
AC A0A0Q3M6R5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=E3 ubiquitin-protein ligase HERC1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AAES_120294 {ECO:0000313|EMBL:KQK78048.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK78048.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK78048.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK78048.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK78048.1}.
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DR EMBL; LMAW01002690; KQK78048.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3M6R5; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 10.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF117289; Nucleoporin domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 13.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 165..214
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 233..285
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 286..335
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 337..388
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 389..439
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 440..492
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1491..1684
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 2906..2947
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3104..3135
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3228..3269
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3482..3530
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3531..3585
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3586..3637
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3638..3689
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3691..3742
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3743..3794
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3795..3846
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 3986..4333
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 819..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1749..1775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1890..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2099..2158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2175..2237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2276..2359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1890..1919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1920..1961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2105..2152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2175..2226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2293..2311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4296
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4346 AA; 476818 MW; 000997C4B9AD1192 CRC64;
MVPPVKLKWL XHLNSSWITE DRPQLPDFER ESLSSDEQDH YLDALLSSQL ALAKMVCSDS
PFAGALRKRL LVLQRVFYAL SNKYHDKANE SKIPPMGLDC LSQGSSADRS QWREPTRTSD
GLCSLYEAAL CLFEEVCRMA SDYSRTCASP DSIQTGDAPI VSETCEVYVW GSNSSHQLVE
GTQEKILQPK LAPSFSDAQT IEAGQYCTFV ISTDGSVRAC GSDGHTLAFT TEGEVFSWGD
GDYGKLGHGN SSTQKYPKLI QGPLQGKVVV CVSAGYRHSA AVTEDGELYT WGEGDFGRLG
HGDSNSRNIP TLVKDISNVG EVSCGSSHTI ALSKDGRTVW SFGGGDNGKL GHGDTNRVYK
PKVIEALQGM FIRKVCAGSQ SSLALTSTGQ VYAWGCGACL GCGSSEATAL RPKLIEELAA
TRIVDISIGD SHCLALSHDN EVYAWGNNSM GQCGQGNSTG PITKPKKVSG LDGVAIQQIS
AGTSHSLAWT ALPRDRQVVA WHRPYCVDLE ESTFSHLRSF LEHYCDKINS EIPPLPFPSS
REHHNFLKLC LKLLSNHLAL ALAGGVATSI LGRQAGPLRN LLFRLMDSSV PDEIQEVVIE
TLSVGATMLL PPLRERMELL HSLLPQGPDR WESLSKGQNS SSVALLHKHL QLLLPHATDI
YSRSATLLKE SSWNGSVGEK LRDKCMSSLL EVALSGNEEQ KPFDYKLRPE ITVYVDLALG
CTKEPARSLW ISMQDYAVSK DWDTATLSNE SLLDTVSRFV LAALLKHTSL LSQACGESRY
QPGKALAEVY RCVYKVRSRL LACKNMELIQ TRSSSRDRWM LDNQESADVD TQEHPFTRTI
DEEAEMEEQA ERDREEGHPE QEDEEEEXEH EVMTAGKIFQ CFLSAREVAR SRDRDRMNTG
TGTRLDDSPP QSQQERRIST DLTEGQDVYT AACNSVIHRC ALLILGVSPV IEEIQKRRED
GQLQQPPSTT SEGIGLMTRS ESLTAESRSI HANSSYRLIK SRSESDLSQP ESDEEGYSLS
GRRNVDLDLA SSHRKRGAIH SQVEPLSDSW VRLKHSRDWL YTSSYSFVES DFDLSRSLGV
HTLIENVVSF VSGDVGNSPG FKEPEESMST SPQASIIAME QQQLRAELRL EALHQILVLL
SGMEEKGSVP LMGSRQVPGF QSSSLLTSVR LQFLAGCFGL GTVGHAGTKG ESVRLHHYQD
GIRAAKRSIQ IEIQVAVHKI YQQLSATLER ALQANKHHIE AQQRLLLVTV FALSVHYXPV
DVSLAISTGL LNVLSQLCGT DTMLGQPLQL LPKTGISQLS TALKVASTRL LQILAITTGT
YADKLSPKVV QSLLDLLCSQ LKNLLSQAGV MLMASFGEGE GEEDGESKKA DSSGENEKRD
FRAALRKQHA AELHLGDFLV FLRRVVSSKA IQSKMASPKW TEVLLNIASQ KCSSGVPLVG
NLRTRLLALH VLEAVLPACE SGVEDDQMAQ VVERLFSLLS DCMWETPIAQ AKHAIQIKEK
EQEIKLQKQG ESEDEDENLP IQEVSFDPEK AQCCIVENGQ VLTHGSGGKG YGLASTGVTS
GCYQWKFYIV KENRGNEGTC VGVSRWPVHD FNHRTTSDMW LYRAYSGNLY HNGEQTLTLS
SFTQGDFITC VLDMEARTIS FGKNGEEPKL AFEDVDAAEL YPCVMFYSSN PGEKVKICDM
QMRGTPRDLL PGDPICSPVA AVLAEATIQL IRILHRTDRW THCINKKMME RLNKIKTCLK
EAGQKLKKSR SIQSRDENEM REEKENKEEE KSKHSRHGLA DLSELQLKML CVEVWPVLAV
IGGVDAGLRV GGRCVHKQTG RHATLLGVVK EGSTSAKVQW DEAEITISDT PLYNLEPCEP
LPFDVARFRG LTATVLLDLT YLTGIHEDTG KQSTKRHEKK HRHESEDKGE MDQKTEGDVG
SDTRLGQSAD DNKGHSTMSS KSENEIASFS LEPSTLGMES QHQPAEGRKK NHEHTPRNHD
IVQSEIRAVQ LSYLYLGAMK SLSVLLSCSK YAELLLIPKV LAENGHNSDC ASSPVVHEDV
EMRAALQFLM RHMVKRAVMR SPIKRALGLA DLERAQAMIY KLVVHGLLED QFGGRLKQEV
DQQVEEGDQS QQAQTPVTTS PSASSTTSFM SSSLEDTTTA TTPVTDTETV PASESPGVMP
LSLLRQMFSS YPTTTVLPAR RAQTPPISSL PTSPSDEVGR RQSLTSPDSQ SARPANRTAL
SDPSSRLSTS PPPPAIAVPL LEMGFSLRQI AKAMEATGAR GEADAQNITV LAMWMIEHPG
NEDDEEPQSE GTADSRHGTI VSGSSGKCSD HCYLQSPGDI PSADATEMEE GFSESPDMDH
VDNAASASGP PPRSRSAVTR RHKFDLAART LLARAAGLYR SVQAHRNQSR REGISLQQDP
GALYDFNLDE ELEIDLDDEA MEAMFGQDLA XDNDILGMWI PEVLDWPTWH VCESEDREEV
VVCELCESSV VGFNQHMKRN HPGCGRSANR QGYRSNGSYV DGWFGGECGS GNPYYLLCGI
CREKYLALKS KSKASTSERY KGQAPDLIGK QDSVYEEDWD MLDVDEDEKL TGEEEFELLA
GPLGLNDRRI VPEPVQFPDS DPLGASVAMV TATNSMEETL MQIGCHGSIE KSSSGRITLG
EQAAALVNPH DRVMALRRVT AAAQVLLART MVMRALSLLS VSGSSCSLAA GLESLGLTDI
RTLVRLMCLA AAGRAGLSTS PATAATSAER SRGIHSKTSK PISCLAYLST AVGCLASNTP
SAAKLLVQLC TQNLISAATG VNLTTVDDPI QRKFLPSFLR GIAEENKLVT SPNFVVTQAL
VALLADKGAK LRPNYDKAEI EKKGPLELAN ALAACCLSSR LSSQHRQWAA QQLVRTLAAH
DRDNQTIPQT LADMGGDLRK CSFIKLEAHQ NRVMTCVWCN RKGLLATSGN DGTIRVWNVT
KKQYSLQQTC VLNKLEGDSE ESLGSPSDLS LSLVCWSISG KYLAGATEKM VNIWQVNGGK
GLLDLQPHWV SALAWPEXGP AATWTGDAPE LLLIGRMDGS LGLIEVVDIS AMHRLELEHC
YRKDVSVTCL AWFSEDRPFA VGYSDGKLLI GTKEPLEKGG VILVDAHKDM IVSMKWDPTG
KILLTCAKEE TVKLWGYMGG CWRRLHSLSH PALVNGIAWC ALPGKGPKLQ LLLATGCHNG
LVCVWTVPQD IVITLQSSST CSEEWWDQET NAKDGYMKAV EVKCVFQLRG HITPVRTVAF
SPDGLALVSG GLGGLMNIWS LRDGSILQSV VIGSGAIQTA VWIPEVGVAA CSNRSKDVLV
VNCTLEWISS NHVLATCRTA LKQQGVLGLN MAPCMRAFLE RLPIMLQEQY AYEKPHVVCG
DQLVHSPYMQ CLASLAVGLH LDQLLCKPPV PPHHQGCLPD PAAWNPTEWA WLECFSTTIK
AAEALARGAQ FPESFTVPDL EPVPEDELTL LMDNSKWING MDEQIMSWAT SRPEDWHLGG
KCDVYLWGAG RHGQLAEAGR NXMIPVAAPS FSQAQQVVCG QNCTFVIQAN GTVLACGEGS
YGRLGQGNSD DLHVLTVISA LQGFVVTQLV TSCGSDGHSM ALTESGEVFS WGDGDYGKLG
HGNSDRQRRP RQIEALQGEE VVQMSCGFKH SAVVTADGKL FTFGNGDYGR LGLGNTSNKK
LPERVTALEG YQIGQVACGL NHTVAVSTDG SMVWAFGDGD YGKLGLGNST AKSSPQKVDI
LCGIGIKKVA CGTQFSVALT KDGHVYTFGQ DRLIGLPEGR ARNHNRPQQV PVLSGIFIED
IAVGAEHTLA LSSTGDVYAW GSNSEGQLGL GHTNHVREPT LVTVLQGKNV RQISAGRCHS
AAWTAPPVPP RAPGVSVPLQ LGLPDAIPPQ YGALKEVSIH TVRARLRLLY HFSDLMYSSW
RLLNLSPNNQ NSTSHYNAGT WGIVQGQLRP LLAPRVYTLP MVRSIGKTMV QGKNYGPQIT
VKRISTRGRK CKPIFVQIAR QVVKLNASDL RLPSRAWKVK LVGEGADDAG GVFDDTITEM
CQELETGIVD LLIPSPNATA EVGYNRDRFL FNPSACLDEH LMQFKFLGIL MGVAIRTKKP
LDLHLAPMVW KQLCCIPLIL EDLEEVDLLY VQTLNSILHI EDSGITEENF HEMIPLDSFV
GQSADGKMVP IIPGGNSIPL TFSNRKEYVE RAIEYRLHEM DRQVAAVREG MSWIVPVPLL
SLLTAKQLEQ MVCGMPEISV EVLKKVVRYR EVDEQHQLVQ WFWHTLEEFS NEERVLFMRF
VSGRSRLPAN TADISQRFQI MKVDRPYDSL PTSQTCFFQL RLPPYSSQLI MAERLRYAIN
NCRSIDMDNY MLSRNVDNAE GSDTDY
//
