ID A0A0Q3PUE8_AMAAE Unreviewed; 882 AA.
AC A0A0Q3PUE8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Integrin alpha-1 {ECO:0000313|EMBL:KQK79716.1};
GN ORFNames=AAES_100850 {ECO:0000313|EMBL:KQK79716.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK79716.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK79716.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK79716.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK79716.1}.
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DR EMBL; LMAW01002570; KQK79716.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3PUE8; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF22; INTEGRIN ALPHA-1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 20..882
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5005965325"
FT TRANSMEM 858..878
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 21..82
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 164..347
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 467..529
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 547..605
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 609..669
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 882 AA; 97837 MW; 6113AFCB92BDB212 CRC64;
MCVATYCFFF KALFHLVGSS NVDVKNAMTF SGPVEDMFGY TVQQYENEEG KWVLIGSPLV
GQPEKRTGDV YKCPVGRDNQ SPCTKLNLPA ATSVPNVIEV KENMTLGTTL VTNPRGGFLA
CGPLYAYKCG RLHYTTGVCS NVSSTFETIK AIAPSVQECK NQLDIVIVLD GSNSIYPWES
VTAFLNSLLK NMDIGPQQTQ VGVVQYGQTV VHEFFLNTYS STEDVMAAAT RIRQRGGTQT
MTALGIDTAR KEAFTEAHGA RRGVQKVMVI VTDGESHDNY RLKEVIDDCE DENIQRFAIA
ILGSYSRGNL STEKFVEEIK SIASKPTEKH FFNVSDELAL LTIVEALGER IFALEATTDQ
QASSFEMEMS QAGFSAHYSQ DWIMLGAVGA YDWNGTVIMV KDSDISMPTN DTFRDRHSEK
SEPLAAYLGY TVNSALTPGG VLYIAGQPRY NHTGQVIIYK MEGKEVQVLQ RLNGEQIGSY
FGGVLTTIDI NRDSFTDLLL VGAPMYMGTE KEEQGKVYVY SLNKTKFEYQ MSLEPVKQTC
CSPLKQDTCK VLKNEPCGAR FGTAIAAVKD LNLDGYNDIV IGSPLEDDHR GAVYIYHGNG
NTISKKYSQR IASGGDGEKV KFFGQSVHGE MDLNDDGLID VTIGGLGGAA LFWSRDVAEV
NVSMQFTPKS INIQQQNCQI NKRKTICINA TICFKTRLKS KEYTFESSLQ YWITLDSQRQ
ISRSLFTESH ERKMQKNITI KGSECIKHNF YMLDKPDFQD SVKVLLEFNF SDPESGPVLD
SNLPSSISEY IPFTKDCGAK NKCISDLVLN VKASIAGDSS SPFIVKSRND KFTIQLSVKN
KKDSAYNTRV LVQYSPNIIF AGIEVXIFHI ITFIITYISG EI
//
