ID A0A0Q3SPR3_AMAAE Unreviewed; 3436 AA.
AC A0A0Q3SPR3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=AAES_28513 {ECO:0000313|EMBL:KQL43672.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL43672.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQL43672.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQL43672.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL43672.1}.
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DR EMBL; LMAW01000481; KQL43672.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3SPR3; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 21.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 22.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 6.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR032485; LRP1-like_beta_prop.
DR PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 21.
DR Pfam; PF00058; Ldl_recept_b; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 19.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00192; LDLa; 22.
DR SMART; SM00135; LY; 26.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 22.
DR SUPFAM; SSF63825; YWTD domain; 6.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 7.
DR PROSITE; PS50068; LDLRA_2; 22.
DR PROSITE; PS51120; LDLRB; 12.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3281..3304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 229..272
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 273..316
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 456..498
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 543..582
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 760..802
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 803..845
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 846..889
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 890..933
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1168..1212
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1937..1979
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1980..2023
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2876..2919
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 3050..3086
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3087..3120
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3122..3158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3159..3194
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3229..3264
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 1356..1374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1390..1402
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1397..1415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1409..1424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1429..1441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1436..1454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1448..1463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1497..1512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1520..1532
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1527..1545
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1539..1554
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1558..1570
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1565..1583
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1643..1655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1650..1668
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1683..1695
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1736..1754
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1748..1763
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2155..2167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2162..2180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2195..2207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2202..2220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2214..2229
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2254..2269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2294..2309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2314..2326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2321..2339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2333..2348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2353..2365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2360..2378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2372..2387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2391..2403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2398..2416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2410..2425
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2432..2444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2439..2457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2451..2466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2490..2505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2512..2524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2519..2537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2574..2589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2599..2611
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2606..2624
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2618..2633
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3054..3064
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3076..3085
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3090..3100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3126..3136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3148..3157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3162..3172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3184..3193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3231..3241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3235..3252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3254..3263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3436 AA; 383328 MW; 1C8C0AB0A3BEAC42 CRC64;
MDMXQAVTEE AAQVNEKYTM ALTPSCVXGY VLQPDNKSCK AKNKPADRPS LLLIASSETI
EVLHLNGSKM SALTPVKGSA ILTLDYSYKE DTICWIESRD LSSQLKCTKI TKAGKLTDEW
IINIAQYLHN VQQIAIDWIT GNFYFLDHVS DRIFVCNQNG SVCVTLIELD LNNPKAIAVD
PTSGFSVRLG VLGNYFDRXD AIKPGEKAVT ITLLCGIVCG KGLKPLPERK LFFTDYGNTA
KVERCDMDGM NRTWIVDSKI EQPTALALDL INKYVYWVDM YLDSVEVVDY QGRKRHTIIK
GRQIRHLCGL AVFENYLYTV DSDNLSILRI NRYNGTDIQS LARLDNAKEI HVYQKRSQTP
VRSHACEVDP YGMPGGCSHI CLLSSNYKAR TCRCRTGFIL GXDGRSCKKR KKFLLYARHS
EIRGVDIENP YFNFITAFTV PDIDDVTVID FDALEERLYW TDVKTQTIKR AFINGTGLET
IISRDIQSIR GLAVDWISRN LYWISSGFDE TQINVAHLDG SLKTSIIHGI DKPQCLAVHP
VKGKLYWTDG NTINMANMDG SNSKILFQNX KDPVGLSIDY GENKLYWISS GNGTINRCNL
DGGNLEIIES MKEDLTKATA LTIMDKKLWW ADQNLAQIGT CNKRDGRNPT VLRNKTSGVV
HMKVYDKATQ QGSNSCQLNN GGCSQLCLPT SEITRTCMCT VGYNLQKNRM ACKGIESFLM
YSVHEGIRGI PLDPNDKMDA LMPISGASFA VGIDFHAGND TIYWTDMGFN KIFRSKRDQT
WKEDIVTNGL GRVEGIAVDW IAGNIYWTDH GFNLIEVARL NGSFRYVIIS QGLDQPRSIA
VHPEKGYLFW TEWGQTPCIG KAHLDGSEKV VLVSLGIAWP NGISIDYEEN KLYWCDARTD
KIERIDLESG GNREIVLSGS NVDTFSVAVF GAYIYWSDRA HANGSIRRGH KNEATDAVTM
RTGLGINLKE VKVFNRAREK GTNICSKNNG GCHQLCLYRG NAXRTCACAH GYLAEDGITC
LRHEGYLLYS GRTILKSIHI SDENNLNSPV RPYENPEYFK NVIALAFDYS LKGRGTNRIF
FSDAQFGNIQ VIKDNWTDRK VLIENVGSVE GLAYHRAWDA LYWTSSTTSS ITRHSVDQRH
QGAFNREAVI TMSEDDHPHV LALDECQNLM FWTNWNEQLP SIMRSTLSGK NAQIIISTDI
LAPNGLTIDH RAEKLYFSDG SLGKIERCEY DGSQRYVIVK SGPGTFLSLA VYDDYIFWSD
GVRRAILRSS KYTGGDTKVL RSDIPHQPMG IIAVANDTNS CELSPCALMN GGCHDLCLLT
PDGRVNCSCR GDRILIDDNR CVTKNSTCNV YSEFECGNGE CIDYQLTCDG XAHCKDKSDE
KLFYCENRGC RKGFKPCSNR RCVSSNKVCD GVNDCGDNSD EFDCKDXTCA STEFRCADGV
CIGKSAHCNQ IIDCADASDE KNCNNTSCAY FHKLGVKSSG FISCNSTSLC ILPEWICDGS
NDCGDYTDEL KCPVQNKPTC EENYFGCPSG RCILTTWLCD GQKDCEDGVD ELHCDSSCSW
NQFACSANKC ISKQWTCDGE DDCGDGLDES DAICGSVTCA ADTFSCLGSH ACVPQHWLCD
GERDCPDGSD ELSTAGCAPN NTCDENAFMC HNKVCIPKQF VCDHDDDCGD GSDESLECGY
RHCRPGEFTC ADGRCLLNSQ WQCDGDFDCP DHSDEGPINI KCRSSEQSCN SSFFMCKNGK
XILQSDVCDN KEDCSDGSDE KSCHINECLS KKVSGCSQDC QDLPVGYKCK CWPGFLLKDD
GKTCVDIDEC SSGFPCSQQC INTYGTYKCL CADGYEIQPD NLNGCKSLSD EEPFLILADH
HEIRKISTDG SNYTLLKQGL NNVIAIDFDY REEFIYWIDS SRPNGSRINR MCLNGSEIKV
VHNTAVPNAL AVDWIGKNLY WCDTEKRIIE VSKLNGLYPT VLVSKRVKFP RDLSLDPQAG
YLYWIDCCEY PHIGRVGMDG SGQTVVIETQ ISRPMALTID YVNHRLYWAD ENHIEFSDMD
GSHRHKVPNQ DIPGVIALTL FEDYIYWTDG KTKSLSRAHK TSGSDRLSLI NSWHIITDIQ
VYHSYRQPDV SKHLCTLNNG GCSHLCLLAP DKMYTCACPT NFYLAADNKT CLSNCTASQF
RCKTDKCIPF WWKCDTVDDC GDGSDEPEEC PEFRCQPGRF QCGTGLCALP AFICDGENDC
GDNSDELNCE THVCLSGQFK CTKNQKCIPI NLRCNGQNDC GDEEDERDCP ENSCSPDHFQ
CKTTKHCISK LWVCDEDPDC ADGSDEANCD KKTCGPHEFQ CKNNNCIPDH WXCDSQNDCX
DNSDEEHCKP QTCTLKDFLC ANGDCVSARF WCDGDYDCAD GSDERYCETS CSRDQFQCSN
GQCISAKWKC DGHEDCKLGE DEKNCEPASP TCSSSEYVCA SGGCISASLK CDGEYDCTDG
SDEMDCVTEC KEDKFRCKNK AYCIPVRWLC DGIHDCVDGS DEENCDQGGN ICRADEFLCN
NSLCKLHFWV CDGEDDCGDN SDEVAEMCVK FPCPPTRPYR CRNNRVCLRP EQICNEVDDC
GDNSDEDHCD KITYKARPCK KDEFACNDKK CIPMELQCDW FDDCGDGSDE QDCKISVAEY
TCEDNVNPCG DDAYCNQTKT SLLCHCKPGF QRNKRNRQCE DINECMVFGA CSQYCNNIKG
SYKCACEKNY KERNNSCIAK GSEDQVLYVA NDTDIVGFAY PFNYSDVRQQ ISHIEHNSRI
TGIDAYFQGD MIVWSTQFNP GGIFYRKLHD WERRQSNSGL ICPEFKRPRG IAVDWVAGNI
YWTDHSRMHW FSYYATHWTS LRYSINVGQL NGPNCTRLLT SMAGEPYAIA VNPKKGMMYW
TVIGDRSHIE ESSMDGTLRR ILVQKNLQRP TGLVVDQFSQ RLFWADFELS VIGSVLFDGS
DSVVSVSTKQ GLLHPHRIDI FEDYIYGAGP KNGAFRVHKF GRSLVEYLSV DVDKAKSALI
FHRYKQMDLP NPCLDLTCEF ICLLNPSGAT CACPEGKSLV NGTCIDQSLL DDSCKLTCEN
GGKCIINEKG DPRCHCWPSY SGEKCETNHC YNYCQNGGTC GASPLGRPTC NCALGFTGPN
CNQMVCEHFC QNGGTCSVTA GNQPLCNCLP EYTGDRCQYY ICHHYCVNSE SCTISDDGSV
ECVCPVRFEG PKCEVDKCIR CHGGHCIINK DSNDIVCNCT NGKIASTCQL CDGYCYNGGT
CQLDPETNIP VCLCSANWSG TQCERPAPKS SKSDNISTRS IAIIVPLVLL VTLITTLVIG
LFLCKRKRRT KTIRRQPIIN GGINVEIGNP SYNMYEVGHD HSEGGLLASD FTVNAEKARY
IGGGPTAFKL PHTAPSIYLN SDLKGPLSTG PTNYANPVYA KLYMDGQNCR NSLASIDERR
ELLPKKIDIG IRETVA
//
