ID A0A0Q3U2D8_AMAAE Unreviewed; 658 AA.
AC A0A0Q3U2D8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000256|HAMAP-Rule:MF_03022};
DE Short=Katanin p80 subunit B1 {ECO:0000256|HAMAP-Rule:MF_03022};
DE AltName: Full=p80 katanin {ECO:0000256|HAMAP-Rule:MF_03022};
GN Name=KATNB1 {ECO:0000256|HAMAP-Rule:MF_03022};
GN ORFNames=AAES_08092 {ECO:0000313|EMBL:KQL60345.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL60345.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQL60345.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQL60345.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in a complex which severs microtubules in an
CC ATP-dependent manner. May act to target the enzymatic subunit of this
CC complex to sites of action such as the centrosome. Microtubule severing
CC may promote rapid reorganization of cellular microtubule arrays and the
CC release of microtubules from the centrosome following nucleation.
CC {ECO:0000256|HAMAP-Rule:MF_03022}.
CC -!- SUBUNIT: Interacts with KATNA1. This interaction enhances the
CC microtubule binding and severing activity of KATNA1 and also targets
CC this activity to the centrosome. {ECO:0000256|HAMAP-Rule:MF_03022}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03022}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC pole {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton
CC {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|HAMAP-Rule:MF_03022}. Note=Predominantly cytoplasmic.
CC Localized to the interphase centrosome and mitotic spindle poles.
CC {ECO:0000256|HAMAP-Rule:MF_03022}.
CC -!- SIMILARITY: Belongs to the WD repeat KATNB1 family. {ECO:0000256|HAMAP-
CC Rule:MF_03022}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL60345.1}.
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DR EMBL; LMAW01000157; KQL60345.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3U2D8; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008352; C:katanin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR HAMAP; MF_03022; Katanin_p80_B1; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR028021; Katanin_C-terminal.
DR InterPro; IPR026962; KTNB1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19845; KATANIN P80 SUBUNIT; 1.
DR PANTHER; PTHR19845:SF0; KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1; 1.
DR Pfam; PF13925; Katanin_con80; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_03022};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_03022};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03022};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|HAMAP-
KW Rule:MF_03022}; Microtubule {ECO:0000256|HAMAP-Rule:MF_03022};
KW Mitosis {ECO:0000256|HAMAP-Rule:MF_03022};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 16..58
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 59..100
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 101..142
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 143..184
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 185..226
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 496..654
FT /note="Katanin p80 subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13925"
FT REGION 311..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 72990 MW; AFB617501C5CC6C8 CRC64;
MAEAVATKTA WKLHEITAHS SNVSSLVLGK TSGRLLATGG DDCRVNIWSV NKPNCIMSLT
GHTSPIESLQ VNTNEKLIVA GSQSGSIRVW DLEAAKILRS LLGHKANICS LDFHPYGSIV
ASGSLDTNIK LWDVRKKSCV FRYKGHTEAV RCLRFSPDGK WLASAADDHT VKLWDLVAGK
LVFEFREHTG PVNVVEFHPN EYLLASGSSD RTVRFWDLEK FQVVSCIEEE ATPVRCVLFN
PDGCCLYSGF QDSLRVYGWE PERCFDMVLV NWGKVADLSV RNNQLIGVSF AQSTVSSFVV
DLSRVTKSDS IPHGLIRDDE PLVPPAPTGS SLRRIYDRPS TSCSKPQRVK HNSESERRSP
SSEDDRDEKE SKAEIQNPED YNEIFQPKNA ICRTPPRNSE PFPAPPEDEP IAAKEAVKPT
RAPHVQMLLP KQELLPNPVQ RPPIASSASL TRAEPLVIPA ARNEPIGLKA SDFLPAVKNQ
SQTELVDEEA ISQIRKGHET MCVVLTSRRK NLDTVQAVWS SSDIKNSVDS AVAINDLSVV
VDLLNIVNQK PSLWKLDLCA IVLPQVEKLL ESKYESYVQT GCTSLKLILQ RFLPLITDIL
AAPPSVGVDI TREERLHKCR LCYKQLKNXS SIIKNKSGLS GRHGSTFQEL HLLMAVLE
//
