ID A0A0Q3U681_AMAAE Unreviewed; 3125 AA.
AC A0A0Q3U681;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Unconventional myosin-XV {ECO:0000313|EMBL:KQL61424.1};
GN ORFNames=AAES_176320 {ECO:0000313|EMBL:KQL61424.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL61424.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQL61424.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQL61424.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL61424.1}.
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DR EMBL; LMAW01000001; KQL61424.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3U681; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01896; DRG; 1.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13201; FERM_C_MyoXV; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 6.10.140.1070; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR045001; DRG.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR031662; GTP-binding_2.
DR InterPro; IPR006074; GTP1-OBG_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041795; MyoXV_FERM_C.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF21; UNCONVENTIONAL MYOSIN-XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF16897; MMR_HSR1_Xtn; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF02824; TGS; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51710; G_OBG; 1.
DR PROSITE; PS00905; GTP1_OBG; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 63..288
FT /note="OBG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51710"
FT DOMAIN 969..1646
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1778..1931
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 2446..2532
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2641..2789
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 2794..3125
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 638..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1547
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 2026..2064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2578..2597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1712..1743
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 1062..1069
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 3125 AA; 351786 MW; 34F2D2B81C70577D CRC64;
MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSSAA KGEGFDVMKS
GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII
EGAAQGKGRG RQVIAVARTA DVVIMMLDAT KGEVQRALLE KELESVGIRL NKSKPNIYFK
PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP
CLYVYNKIDQ ISMEEVDRLA RRPHSVVISC GMKLNLDYLL EKLWEYLALT CIYTKKRGQR
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWKLGL RRPKKGQFKN TSRFFWGLQK
RSTNKRKKKK NKAVLKSTSN LMVRFKRVGK KRKDASGSAP PXKPSFLLLR RGATAAAEDG
ASLFRRRPER KFKPRAQVLS KAAAATGWLA XKVLNRRGRL AGGSRAADTA WLSRIGARKL
PFPAEDEILR HRANMKRIPA GSSRLPGPGV ARHGSMARRP SRRXSQRASA EXPVXRYGWA
EEEDGAYSRR HGYSKEEDGA YGSCXGYAXK EDGAYGRWRG YNKEEDGVXG PQRGYTEEXG
DYXPWRSYSE EEEDGAYSPQ XGYAGEEEGY TQAPAYPEAY GYEDVGPSPY SDYPGYEAEQ
DYGFYGGAWE EGEQQGPPYG YXGLEDEGPF GGGSPLALYD PYGSDQEYGA DTXGPFGYRE
DPYEDFGDPF SGRYPGGEHP EHRIQYSEGG WAPHAQSCNP YALALEEIAE AEEPEEWDEE
EEEDKDYPFS ILSASSLRGM RETLSSKLSL NGNFRLFPRL RAPGSPATPR RGTRAPEAAE
GDALSGEEGA GRYAVVTPQV QRLGSFRRAS RMYKQHWSTQ HVVXVREMPD AWTAEQAPPQ
LPSQRGRRWA SQRGADIARY LSQRSPGGGW RDRHPWADGY LGSKQPWRSK MQSLCSLPIV
RYQEPQEEDG LEDMTQLEDL QEAAVLSNIR TRFERQLIYT YIGSILVSVN PYRLYDIYGT
EQVLQYEGRA LGENPPHLFA IANVAYSKVM DAKHNQCIVI SGESGSGKTE ATKLILRYLA
AISQKRSTAP QILEATPLLE SFGNAKTVRN DNSSRFGKFV EIFLEDGLIC GAITSQYLLE
KSRVVFQAKS ERNYHIFYEM LAGLPAQQRQ RYCLQGAETY YYLNQGGNCE IPGKNDAEDF
HRLLNTMEAL SFSVEEQNSI FRILSSVLHL GNVYFDKYES DCQEVAMVVS ATEIRTVAEL
LQVSPEGLQK AITFKVTETL REKIFTPLTV ESAVDARDAI AKTLYSLLFG WLTDRINKLV
YPRQEALSIA ILDIYGFEDL NFNSFEQLCI NYANEYLQFF FNKIVFQEEQ EEYLREQIEW
KEIPFSDNQP CIDLISQKPY GILRILDDQS CFPQATDHTF LQKCHYHHGT NPLYTKPKMP
LPEFTIKHXA GKVTYQVHKF LDKNYDQVRQ DVLDLFISSR TKVVANLFFG HAQVMARQRS
LIRRSSTRTR RYKAPTVAAR FQQSLLDLVE KMERCNPFFV RCLKPNNKKE PGLFEADVVS
SQLRYSGILE TIRIRKEGFP IRIPFLVFID RYRCLVDMWS NVIPNGTNCV EMLRNLCPVN
PSMYYVGVSK LFLKEQLYQA LESKRARAHH LAALTLQRYA RTFFIKRRFR SLRRKIVLLQ
SRARGYLARQ RYRRMRHTLI KFRSLVHIYV NRRRYLKRKE DARRRAEEEK ERMKQELTRR
EVVDVTHLEI PAELMGLLEA AAAGREVNAG CVVLVPPPAL QPDSQLTLPL DINDYPMAKY
VRGHFQILRF MGDPALGGSQ ETLFGNYIVQ KGLSVPGLRD ELLAQAANQV WRNTNVNNEE
RGWLLLAACL SAFPPSAAFD KYLLKFVSDY AFAGYKPVCQ RKLMHAMARS QLGAAAXRAY
PPSLLEWTAN RQQASMALDL HCFNGAVMWG WGTRQRGGLV EGWRGWSVAM KAGXQWAELA
GHDYVLDLIS DLEMLXGFPK QKSCFLVAWD GAESHSGDSQ AVLGHSLDLD EVPPPPAVKA
PTLPSTEVYH PHGDGEFGEP RSQKGLDRYL DSLFDPVLSY GNGGRAAEGT PARASQPRPY
MQKAAPMGRW WPGELVRNSR LNSEHFPRPT HDIRNIIRQC QPAPRGSQPH RXPLRPSETP
APPAPGCMCW PWCRDAGNAG DAGDASKLFG KKQDPHEEAM QILKEQLSAS PVPVAVGPKE
VVATVKPVTS SRYPLRPPTG CAVATRPTVS VSRELPSEAQ QVQTQLHRSC SEDFYTYHNV
PWKIYIRKEV FYPKDSINNP LLLDLIFRQI FNDVLSNTCI RLSQEERLRX KSLFAENKLD
SFSPVATESV KREIIAAARD GCEVYFSRLF PATGSVGTGV QILAVSHTGV KLLRMVKGTN
VPGEQLRVLR AYGYADVLFV TTPSRNMLEL NLRSEKLILF SPKAPQDSQY VVAVRNYSPE
DRGQLSFHKG DIIHLQPLKH PERDHYYGCV VRKKVMYLEE LKTGTQDFGW KFGAIHGRLG
LXPAEYVQPV AAPDFVHLPA ERKEEPRDKQ GKVVASAAVA VAVASTXVAQ ELDRKSEASL
ASTAEGPEGD SSEKLGDSTG TCSMLAFARQ YFRVARHGET MEPCGMKAKR DVPNVLEMLT
FSKTPIQESL IEFVDGGISK LATEAFQAVM KFMGDHPLRG QTELDTVCTI LKLCAEHEVL
RDEVYCQVVK QITNNSSSKP ILAGTRSCLS MVGAVHAAGC GVHGAQLHPS SWSRSLPGIA
KACELNLQKT LQFGGRRLFP SSMELRAMVA GRSAKRQLFL LPGGIERHLK IKTCSVALDV
XEELCHXMGL QHPEAFEXYI LFVVTDRGEG LVGTGWLCTS VRPLTRREYV LDVATETERW
DPSYTFWCRR VVWGQPLKFD NELYVTVHYN QVLPDYLKGL FTVLPPARPG EQHFPHVAKL
AALQHRAKDH HHLPTAREVQ DYVPPQLFRL LKAQSWIHMV TQHMQQAQAL SAHQARAQFL
GLLSAYPMFG SSFFYIQSCS NNAIVSPCIL AXNQNGLNFL SKETHEPIAK FSLKEIQSTR
TQRPTAGSSY PYVEITLGDL LAQGITQLQL EQGLELCRVV AAHMERLLGA REKRLTLPPS
EITLL
//
