ID A0A0Q3XBQ1_AMAAE Unreviewed; 977 AA.
AC A0A0Q3XBQ1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN ORFNames=AAES_13380 {ECO:0000313|EMBL:KQL61477.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL61477.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQL61477.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQL61477.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQL61477.1}.
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DR EMBL; LMAW01000001; KQL61477.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q3XBQ1; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd07912; Tweety_N; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF4; PROTEIN TWEETY HOMOLOG 3; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF04906; Tweety; 1.
DR SMART; SM00015; IQ; 2.
DR PROSITE; PS50096; IQ; 2.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 495..520
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 532..559
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 663..684
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 691..710
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 841..862
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT REGION 79..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 104..145
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 374..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 110094 MW; 0106795E182F74A3 CRC64;
METAASEDVL FASAAYSQGD DGPSALTCES DPELKLKKKL FTKPPKLPNR MSYPLKSDVG
VGHVQAGFSS TPEYLKEVLG TKKPKHSHSS SSGCIPGNPN YKEKEDMYDE IIELKKTIQA
QKIERHQMKT KLRRLEEMIN RKDKQIEKLL DPFKVVNGLK QKILKLQQLC KERDKTIKYD
FIGYGGGKFQ ADIKYTDLEE MKIAMETCSE EKISAMDYAR VPSADTCESE VFAPPRSISD
DLDDPVSQHV DCVEECHRLQ RLVKKLQRDK KALRSFLLSK EVEIQNLTQK LGKLEPEEEE
EKSQMAEDKV EKGLKFSLQG KDHQRREEAA RIIQRYWKKY QDKAITTLQT AFRGHLGRQK
LLLKKRTHEA NSHNKNSCRS SMSNSSSSSS DCKEEDEMLP FIQSVFRAHL ARKEQLAERT
ADPSLVGRSQ SSSAGVSYTS SWEEVHLLYR SSGMTNRTRK DSPCNSACPT RLDFIWSLIE
FVDKIMKSNM TVNEALLLLG GIALSCLALD LLFLLFYSFW LCCRHRKSEE HLNADCCCTA
WCVIIATLVC SAGIAVGFYG NGETSDGIHR LTYSLRHANR TVAGVQDRVL DTAVALNQTA
EPNLLVLEEM FTKQTDYLHV IQKLQGLLDE LVRQTTEIPF WKNEELSLEE LAIQIDLYDW
YRWLGYLGLL LFHVLICLLV LFGLIRNSRA ILMGVCLLGV FALIVSWGSL GLELAVAVGS
SDFCINPDAY VSKVVEENAV LSADTLRYYM TCSAGYPNPF QQKLSASHKA LVEMQDDVVE
LMRSATREHP TSKEYLTRIQ EVLNSTEINL QQLTALVDCR SLHLDYVQAL TGFCYDGVEG
LIYLVLFSFV TALMFSSIVC SVPHTWQQKR SSDDDGEEES AAQGSRQTHD NLYRVHMPSL
YSCGSSYGSE TSIPAAAHTV SNAPVTEYMS QNANFQNPRC ENTPLIGRES PPPSYTSSMR
AKYLATNQPR PDAGSVH
//
