ID A0A0Q4KDU5_9SPHN Unreviewed; 496 AA.
AC A0A0Q4KDU5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQN25007.1};
GN ORFNames=ASE86_01665 {ECO:0000313|EMBL:KQN25007.1};
OS Sphingomonas sp. Leaf33.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1736215 {ECO:0000313|EMBL:KQN25007.1, ECO:0000313|Proteomes:UP000051455};
RN [1] {ECO:0000313|EMBL:KQN25007.1, ECO:0000313|Proteomes:UP000051455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf33 {ECO:0000313|EMBL:KQN25007.1,
RC ECO:0000313|Proteomes:UP000051455};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQN25007.1, ECO:0000313|Proteomes:UP000051455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf33 {ECO:0000313|EMBL:KQN25007.1,
RC ECO:0000313|Proteomes:UP000051455};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQN25007.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMLB01000001; KQN25007.1; -; Genomic_DNA.
DR RefSeq; WP_056421775.1; NZ_LMLB01000001.1.
DR AlphaFoldDB; A0A0Q4KDU5; -.
DR STRING; 1736215.ASE86_01665; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000051455; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000051455}.
FT ACT_SITE 77
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 13..16
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 77
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 184
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 332
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 341
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 496 AA; 53836 MW; BECE2C77727C8F4E CRC64;
MTEPAPTIVI LGGGTAGWMT ACLMAQAWPA AAITVIESPD IGIVGVGEGS TPQLRAFFRD
LGIAETDWMP ACSATYKAGI RFAGWSQDPG FDSYIHPFAS DVDLHTEPAF HAAALARRTG
HDVPAHPDAF FLNSWLIEHR RAPLPTDNFP FDAAYGYHFD AHLVGAYLRD HAVGRGVAHL
PRTVTDVVVG ADGDVRHLLF DDGHTLTADL FVDCSGFRSV IAQEALGVPF VSFASNLFND
RAVVMPTPSD PTGTDVHTTA TALSAGWAWA IPLTSRVGNG YVFSSRYLDA HDAEAEFRAH
LGVGDAGTAR HLTMKVGWVA TSWTGNCLAV GLSQGFIEPL EATALHIVQA TVEGFIAAWD
SAGFTPARRD EFNRVIARRY DGIRDYIVGH YRLNRRTDTP YWRDAATMDT LSDSLKSLFT
AWFTGRDLVE EVARQDIAKY YAPLSWGCLF GGYGTYPDAA RLRTGTSVDT GRIAHFLTAC
GRNFPAHDAV LALRRG
//
