ID A0A0Q5LUZ8_9MICO Unreviewed; 1211 AA.
AC A0A0Q5LUZ8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=ASF88_04985 {ECO:0000313|EMBL:KQR54177.1};
OS Leifsonia sp. Leaf336.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leifsonia.
OX NCBI_TaxID=1736341 {ECO:0000313|EMBL:KQR54177.1, ECO:0000313|Proteomes:UP000050966};
RN [1] {ECO:0000313|EMBL:KQR54177.1, ECO:0000313|Proteomes:UP000050966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf336 {ECO:0000313|EMBL:KQR54177.1,
RC ECO:0000313|Proteomes:UP000050966};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQR54177.1, ECO:0000313|Proteomes:UP000050966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf336 {ECO:0000313|EMBL:KQR54177.1,
RC ECO:0000313|Proteomes:UP000050966};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQR54177.1}.
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DR EMBL; LMOZ01000001; KQR54177.1; -; Genomic_DNA.
DR RefSeq; WP_055915020.1; NZ_LMOZ01000001.1.
DR AlphaFoldDB; A0A0Q5LUZ8; -.
DR STRING; 1736341.ASF88_04985; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000050966; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000050966}.
FT DOMAIN 671..832
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 857..1007
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1211 AA; 132135 MW; C350B9BCEACB737B CRC64;
MILQGLIAAL ERASTFSDAL AYAARDADFS LTDGLRAPLL AGLVGKRGAA GASQAVLVIT
ATGRESESVR AALPCVLPDA EIVEFPAWET LPHERLSPSP EIVGKRLVAL RRLADWSAAR
DAGEPSHPFI LVASVRAALQ PLADNLTDYA TIALDAGGRG FDLGGLALHL VDLAYARVDM
VTRRGEFAVR GGILDVFPPT AEHPYRVDFF GDEVEQIRAF SVADQRSLPE PIPSVSLPPS
RELLLSEPVR QRAREMEHEF PSLSAMLAKI GEGIPVEGME SLAPALVDRL VPLTHYLPEG
AAVAVLSPER VASRAVSLAE TNREFLSAAW SAATVGAAAP IDLAAGDFLT LQKLRDSVKF
SRPGQQNPDH PWWTFSGFQA DAVDEQPLER EVEEYLQVRV AAEAVPSFQG NVTGAVEHVA
QRLRDGWQVA IVAEGAGLVE RAAQVLADAE LPARPVEEFP ENPEPGVAYL LRANVEHGFE
MPDVKLALIG ESEFYGRSVG YESRQVKKLA TRRKNVVDPL ALKPGDYVVH ETHGIGKFLE
LTQREVSSGG RNAVKSKREY LVLEYAPSKR GYPGDKLYVP TDQLDLLTRY VGGEAPQLSK
MGGSDWSAAK GRARRAVRDI AVELVKLYSA RMASKGHAFG PDTPWQRELE EAFPFAETHD
QLQTIDEVKA DMERPIPMDR LISGDVGFGK TEIAIRAAFK AIQDGKQVAM LVPTTLLVRQ
HAETFLERFA GFPIHLRELS RFQTDKEARE TLRGMADGTV DIVIGTHRIL ADGVAFKDLG
LVIIDEEQRF GVEHKDALKK LKTNVDILAM SATPIPRTLE MAVTGIREMS TLATPPEDRH
PILTFVGPYS ERQVAAAIRR ELLREGQVFF VHNRVGSISA TAAKLAELVP EARIAVAHGR
MNEHALEQVV VDFWERKFDV LVSTTIIETG LDISNANTII IDRADKYGLS QLHQLRGRVG
RGRERAYAYF LWDEDKPLSE TAHDRLSTIA ANNDLGSGMQ VALKDLEIRG AGNLLGGEQS
GHIAGVGFDL YLRMIGEAVS TFRGEVAEGQ TELRLELPVD AHIPEEYVDS ERLRLEAYQK
LSTASSPAAK DGQIDLVLEE LTDRYGEPPE PVVNLIAVSR LRRAAQRAGL GEVVAMGSNL
RLAPAQLPDS LQVRLQRMYP GSKYHVAPKV ATVPLPRVNG EAPDDAALIE WVATLLGALF
PTPEPASEPA A
//
