ID A0A0Q7S9I5_9BURK Unreviewed; 490 AA.
AC A0A0Q7S9I5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Tryptophan halogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASD35_10790 {ECO:0000313|EMBL:KQY79353.1};
OS Pelomonas sp. Root1444.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Roseateles.
OX NCBI_TaxID=1736464 {ECO:0000313|EMBL:KQY79353.1, ECO:0000313|Proteomes:UP000051648};
RN [1] {ECO:0000313|Proteomes:UP000051648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1444 {ECO:0000313|Proteomes:UP000051648};
RA Garrido-Oter R., Mueller D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQY79353.1, ECO:0000313|Proteomes:UP000051648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root1444 {ECO:0000313|EMBL:KQY79353.1,
RC ECO:0000313|Proteomes:UP000051648};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQY79353.1}.
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DR EMBL; LMFP01000033; KQY79353.1; -; Genomic_DNA.
DR RefSeq; WP_056877798.1; NZ_LMFP01000033.1.
DR AlphaFoldDB; A0A0Q7S9I5; -.
DR STRING; 1736464.ASD35_10790; -.
DR OrthoDB; 8868802at2; -.
DR Proteomes; UP000051648; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000051648}.
FT ACT_SITE 78
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 13..16
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 78
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 325
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 334
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 338
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 490 AA; 55644 MW; 299E0732D88F517E CRC64;
MTQKFDRIVV VGGGSAGWMT AMALVTGLKG RVNVEVVESE EIGIVGVGEA TFPSIRHYNQ
LVGIDETEFL RATNGTYKLG IRFCDWLEVG RDYFHTFGHF GNLFGSQTLW AQYRRMRLAE
PLGLQCVPTV MAMQGRFALP SEQDQFKYAY HFDAVRYAAF LRQLAMQRGA RHTQGRIVDV
VRRADGGVAA VQLDDGRRVE GDIFVDCSGF RSLLLGGALQ EPFVDFSHWL PVDGAWACPT
ERVGEELAPY TQATALEGGW AWRIPLQNRT GHGHVFASRF IDPERAREQL LARLDGKPVA
EPRLLRFTTG HRQRFWVNNV IAIGLSSGFL EPLESTSIYL IQDGISRLMT MLTAGRPLDE
NDRALFNDGS VRRFARIRDF IILHYCLTRR RDSELWRHVA TMELPETLAF RMELWRRYGV
LHEYDEEGFD ATSWLAIHAG MEHWPERDDP VFAEIPPERA LQALQGRRNA IAASVARMPL
HHQMLGQVLR
//
