ID A0A0Q8P985_9ACTN Unreviewed; 2142 AA.
AC A0A0Q8P985;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KRB70006.1};
GN ORFNames=ASE03_25445 {ECO:0000313|EMBL:KRB70006.1};
OS Kitasatospora sp. Root187.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=1736486 {ECO:0000313|EMBL:KRB70006.1, ECO:0000313|Proteomes:UP000051829};
RN [1] {ECO:0000313|EMBL:KRB70006.1, ECO:0000313|Proteomes:UP000051829}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root187 {ECO:0000313|EMBL:KRB70006.1,
RC ECO:0000313|Proteomes:UP000051829};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRB70006.1, ECO:0000313|Proteomes:UP000051829}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Root187 {ECO:0000313|EMBL:KRB70006.1,
RC ECO:0000313|Proteomes:UP000051829};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRB70006.1}.
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DR EMBL; LMHX01000014; KRB70006.1; -; Genomic_DNA.
DR RefSeq; WP_057241032.1; NZ_LMHX01000014.1.
DR STRING; 1736486.ASE03_25445; -.
DR Proteomes; UP000051829; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 2.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR047738; SAV_2336-like_N.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; NF041121; SAV_2336_NTERM; 1.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 2.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00486; Trans_reg_C; 2.
DR SMART; SM01043; BTAD; 2.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00862; Trans_reg_C; 2.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR PROSITE; PS50901; FTSK; 1.
DR PROSITE; PS51755; OMPR_PHOB; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00289};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00289};
KW Reference proteome {ECO:0000313|Proteomes:UP000051829};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1071..1337
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1345..1444
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DOMAIN 1597..1700
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DOMAIN 1910..2093
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT DNA_BIND 1345..1444
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT DNA_BIND 1597..1700
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 47..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1927..1934
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 2142 AA; 230773 MW; 690680833603E6DA CRC64;
MDEREPDATA QAALREALAQ LLAPAGGDPL SQDLADVLWI SRLTGLAPLP AGGAAPHGDT
PTRAEEPEPL TVDQPEPAAE PSGPAQPSAG PKAELHPRAA AEATGPVGSR GGEAVQVTRP
AALPGALGLA RALRPLRRPL RNPVGRVERA GLDEEATADS TADVGVLLPV WRQEQQRRFS
VDLLVDTGAT MAVWHGLAGE FATLLERHGA FVDVRCWSLD TDHAVPHLTP FRRRSRRPRA
ASQPSGPARN WARPLADPLG RRILLVLTDG VGPAWYGEEL PAFLARALGG RPAAVLQVLP
RRLWHRTALR PAPVEGRAAT HGQSAPVLRS DAALPGIPRG PRGSAARAAV RWLPVLEIDA
EWLAPWAEVV AGRASGWTPM LAAPVRGVPR PQHPGRAVEE PVTAAERVAR FRAGSSPGAY
RLACHVAAAP LSLPVMRLVQ QATLPGTGQQ ELAELFLSGL LELREEALDP DEVVYDFREA
VREELLAELT RSESVRVLES VLAKVSGRVA ATFGGTLDFR ALAATAGAGG LALPSRSRPF
AEVAVAVLAG AGGQHAALAR TLSAAVEAGA GAGAGVADGT SVRGAVIRHE LLGPAPIISP
PDPLRMIGRQ HKLALLEQAA LADRHSTVVI EAVPGLGKRR LVQEYIQWHG ARHSFIHWID
GDTVSVVAGL AQLRSALDPA DLPSASFPPL SQLLREHPGW LIVIDGLSQD SVLTSLGVRF
GLADAGPGCL IVTTGLLDSS RARDDATVIT LGELTDDELL HELRLRLDEL SPGREQDEQL
RQLLEILPRN PGLLMQWDLD AELTAIAGFS VQGGDLEASA TESAVRRVRT YRLREPAVAM
AAIPSPAGQL RLAVYGRSGQ VHFYDLTDGS VVGEPITLRH AAEVVAMAAL SDEDGRVVLY
TADRDGQLSC WSSEDGSLLA RHQGFPRRPV AMAGFGHADR SQSLWAVDDE GHTHLWDPIA
LRATRPDIPL FDGRTATTVP RVAGPSALLV AESTGLVYRC ELDGSDRVVL SIIGPAAART
IVGLSDSPYE CASLGDQDDL VQVWEMSVAP RRAAPHDRTG QDTGRIVADR YRLVRQIGRG
GAGEVWKAVD ELGGSAVVVK LFDRSRGGRD SRRLSRFLSQ AETVRGLRHR GITTVRDAGV
EDDTGYLVLD LIDGPDLRGV LAGGRLPLSR AVAVARRVAE ALDYLHDHGV VHHDIKPANI
LIPAAGEAVL CDYGFDWAGP RWSGSDTTSV EISRELVTPR YMSPEQAGGA VAGPTSDLYS
LGCVLYEMLT GAPPFTDRSE ALLTSRHIDT APAFPQQIEP EVPQALDVLV RELLQKDPDL
RPQTAAEVAR RLASPGVLRR PDRPAESESE SPLRFTVLGP VRAWRGEDPV ELSPRQLAVL
AVLILNHGRP VTTSELVDAV WQRAPRSAAE ELGTYLRQIR RALNAGSAEP DVLVSGNDGH
TLRVGAGAVD VVLFEDQLHR ADEDLRNDDP RAALRHVRDA LAVWKGRPLE DVPGPFASAQ
RARLQERHLD AQEVWFEAEL WLGQAAELVA ELQELTFEYP LRERLRAFLM LALYRSGRSA
EAVDVYIDTQ RVLREEHGRR PGAELADLYG RILAQDPGLL LPGQGPRFLI LGPLKAWRDE
PLSLGPPQQQ AVLAILLLNA GRTVTVQTLV DGIWGDRPPQ AVAAVRTYVS RLRAVIDPSH
RVRQPHQVLM SVADGYALMV PPASIDLSEF DSRMAEATSA RAAGALDRAY ELLLSALSLW
QGTPLAGIPG PYAERRRAEL AERRIAALEV LHTVALDLGR HEESAGELAL LAADHPLRER
LRALQMLALH RCRRSAEARN VYRGARQLLV EELGVEPGPV LTALYRRIDA DDPDLLHGSV
DDLFERLTAV EPVQPPTGGR LPLVLDKIAL PDGFEFPELG VAFGIDDTDL APVFIDFETD
PLLIVLGESE SGKTALLRLL IEKITQRYAP DQAGIVVGDY RRSLLGVVPT AYLMDYAASA
PRLAEIAETV RGACEQRLPG PDVTPEQLRN RSWYTGKDMF VIVDDYELVA TSSGNPLAPL
AEYLPFARDL GLRIIIARNS NGAGRAMYEP IMQRMKELGG QGVLLSGDEQ EGELLHGVRL
QPLPPGRGIY VSHRHRSGTL VQTALLPPSG PLAIEAAPSP PG
//
