ID A0A0Q9WMK4_DROVI Unreviewed; 2100 AA.
AC A0A0Q9WMK4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:KRF81653.1};
GN Name=Dvir\GJ17499 {ECO:0000313|EMBL:KRF81653.1};
GN ORFNames=Dvir_GJ17499 {ECO:0000313|EMBL:KRF81653.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:KRF81653.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:KRF81653.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH940649; KRF81653.1; -; Genomic_DNA.
DR RefSeq; XP_015028417.1; XM_015172931.1.
DR STRING; 7244.A0A0Q9WMK4; -.
DR EnsemblMetazoa; FBtr0441827; FBpp0398337; FBgn0204669.
DR GeneID; 6628873; -.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG3509; Eukaryota.
DR InParanoid; A0A0Q9WMK4; -.
DR OrthoDB; 101939at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:EnsemblMetazoa.
DR GO; GO:0031012; C:extracellular matrix; IEA:EnsemblMetazoa.
DR GO; GO:0005615; C:extracellular space; IEA:EnsemblMetazoa.
DR GO; GO:0097730; C:non-motile cilium; IEA:EnsemblMetazoa.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:EnsemblMetazoa.
DR GO; GO:0000902; P:cell morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0042052; P:rhabdomere development; IEA:EnsemblMetazoa.
DR GO; GO:0010378; P:temperature compensation of the circadian clock; IEA:EnsemblMetazoa.
DR CDD; cd00054; EGF_CA; 10.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.10.25.10; Laminin; 12.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 10.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000008792}.
FT DOMAIN 165..201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 203..239
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 241..277
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 279..319
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 321..357
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 359..395
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 397..434
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 946..982
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 993..1194
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1237..1274
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1281..1477
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1473..1509
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1511..1549
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1620..1807
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1803..1840
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1841..1874
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1880..2090
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 540..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..892
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 169..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 229..238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 267..276
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 309..318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 347..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 385..394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 424..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 972..981
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1264..1273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1499..1508
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1539..1548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1830..1839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1864..1873
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2100 AA; 226394 MW; 8CB2CA54BABAAAD0 CRC64;
MERENLKREL CRRRDVITNK CIKYAQSTTT ITTAATTTTT ATTTPLTANG TTTTGPILEV
ALSSSTTKPL TDMQRNHLLK MPTKTATTAT ATATATTTAT KTKGLPTTVN CANSAAAAAA
AAAAGATTTA QSIARTLRTL VHSCPQTGLL LTLCLSLSLV CVSQAGFACL SNPCVFGVCI
DGLNSSYSCY CIDGYTGIQC QTNWDECWSG PCQNGGTCVD GVAYYNCTCP EGFSGSNCEE
NVDECMSNPC QNGGLCRDRN NGYTCTCQPG YLGDHCEVDV AVCDTGTGAR CQHGGECIEG
PGLEFSCECS AGWHGRICQE EINECASSPC QNGGVCVDKL AAYACACPMG YTGVNCEEEI
LICADNPCQN NALCLMEENI PTCYCVPDYH GEKCEFQYDE CQLGPRCMNG GVCIDGVDTF
SCSCPPLLTG MLCECLMVGE ESLDCNYTSP PTSAPPVVPV TPSMFPSTLA PPTVRPVTPP
ETTMAPSTPP AAPVTTTPVV ELSSSSEEHF VGVKVTAAPP ESDSHSIDKD LTTSRPHLEV
ELTPEMQPTA GPTTPPAGGS SSASSSEESH AIYTTIPPVP VPGVTSSSAE GSSEVVTSEE
YTTVRRFDIS GSGGSSSSEE PTTTMRPTSP QRPSITIAVD YPSSGSSESV EQPMTVTTPG
SIFVHRVTTF GTSISVDYAP TPTPYFPPET TLRATKSPLE ETTRHLWTEL PTTAAPFFTD
YPAEVLITTH RTSAGRFTTV QPPTQQETTT APLDYEPASV ELTTAQAPHI VVTILEGNTT
IPTTTYMPTM TTQRLQPQTA HATTELPLEW EPSTTQLPPA VTMPMPVEVT TSQTITTEDL
LGPPVPPLMT IEPPRETTTP RAIPMPTEPP TLPSLPAATV PPTPPSTQSA QTMPPPTPAV
HAYSTPGQPE LPAQTKPPVT ESSEESEGAN TVAIGSAGGG AEEKSGDVDC VKLGCYNGGT
CVTTSEGSRC VCRFDRQGPL CELPIIIRNA AFSGDSYVSH RIYKDIPQHE ALDAVLPMHI
QLKVRTRATN GLIMLAAAQG TKGGHYMALF LQKGLMQFQF SCGLQTMLLS ELETPVNTGH
EITIRAELDF SRNYTHCNAS LLVNDTLAMS GDQPTWLKLL PPRLHTPEVI LNTWLHLGGA
PQAPIGLIIE LPPAQSGTGF TGCLHTLRIN GQSREIFGDA LDGFGITECG SLACLSSPCR
NGAACIKIES NELDANGDKA EKWKCKCPTG YMGPTCEISV CEDNPCQYGG TCVQFPGSGY
LCLCPLGKHG HYCEHNLEVA LPSFSGSVNG LSSFVAYTVP VPLEYSLELS FKILPQTMSQ
ISLLAFLGQS GYHDEKSDHL AVSFIQGYIM LTWNLGAGPR RIFTQKPIDF RLDAPRVPYE
IKVGRIGRQA WLSVDGKFNI TGRSPGSVSR MDVLPILYLG GHEIANFNTL PHDLPLHSGF
QGCIYDVQLK AGQVTVPLQE TRGVRGRGVG QCGTRECHRH ACQHDGACLQ HGATFTCICQ
EGWYGPLCAQ ATNPCDSFNN KCYEEATCVP LVNGYECDCP VGRTGKNCEE EIRSLSDVSL
TGRRSYLAVR WPYLYDGGDK LGAKRSQMVS YRNFTKKLMP PKPISTPSTH FVMKLLNEVE
KQRSFSPVPL MGSKTFEEHH RVQFFFIEFQ LRPLSERGLL LYFGTLNNNQ DKKIGFVSLS
LQGGVVEFRI SGPSNHVTVV RSVRMLAIGE WHKIKMAQRG RWLTLWVEGS ASSALAPSAE
VLVEPDSLLF IGGLKDVSKL PHNAISGFPI PFRGCVRGLV VSGTRIVLNE TNIVESRNIR
DCDGTACGGD SCESGGHCWL DEKLQPHCIC PDYAKGDRCE YSETCKLIPC KNNGRCLRSG
RCSCPNGWGG FYCEIALSKP TTPSFRGNSY LILPPPRIPM KDKRRGPSLY ARPRETIQIS
LNFSTIEPDG LLLWSEHNPV KFLGLGLENG HLKLANNLLG SNNDTVQAPA SGFVADGAWH
GISVLLDRTR LELQLDGAVI FTERLPELSR RMTTTPTTSF QRRGSKEPTI SYEDIFYLGG
FPNQDSVSMR TQGRFFEPFK GCLQDIQFGA EPKAVINDFS TYQGENIGSC DLHGDEPIIL
//
