ID A0A0Q9YSV0_9COXI Unreviewed; 857 AA.
AC A0A0Q9YSV0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=RasGEF domain protein {ECO:0000313|EMBL:KRG20004.1};
GN ORFNames=CC99x_00225 {ECO:0000313|EMBL:KRG20004.1};
OS Candidatus Berkiella cookevillensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Berkiella.
OX NCBI_TaxID=437022 {ECO:0000313|EMBL:KRG20004.1, ECO:0000313|Proteomes:UP000051494};
RN [1] {ECO:0000313|EMBL:KRG20004.1, ECO:0000313|Proteomes:UP000051494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC99 {ECO:0000313|EMBL:KRG20004.1,
RC ECO:0000313|Proteomes:UP000051494};
RA Mehari Y.T., Arivett B.A., Farone A.L., Gunderson J.H., Farone M.B.;
RT "Draft Genome Sequences of Two Novel Amoeba-resistant Intranuclear
RT Bacteria, Candidatus Berkiella cookevillensis and Candidatus Berkiella
RT aquae.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRG20004.1}.
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DR EMBL; LKHV01000001; KRG20004.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q9YSV0; -.
DR STRING; 437022.CC99x_00225; -.
DR Proteomes; UP000051494; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000051494}.
FT REPEAT 35..67
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 419..664
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 267..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..291
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 98945 MW; 49CF0DE21B8974CD CRC64;
MSKLISLIEN KEYKSAEQYI KKQKYIRWND HLNQDGKSAL HLVAMTGPLS LLQLMIARGC
PWDMMDNHGF TPIHYARKAN QVDIFLELNE MYKIVGIELP SEFISDIQSL YYPKRKFSVL
DRLGRKSIPQ DISITNEPVP VIYAGSSSSR DAYLESPISD GTVDQKIPIL HTPRNLIAQL
EDCYNVPDAL PHYELESELD CYNRYQMLFK KMHSEYIKAK NNLELSLFEA GLTIVDRLEK
PNENNKHAIK KIRRKLKNID EMFIPVDSEE KKHPSEHKHQ KSKRKARVKK DKPASMLKNN
IRQLFVSSSV SDSVLTRLRP EDIRYLAISF FHNYEPIAIL KEIISAWYWM PNKMKPASIY
FVMQLINADN SILHIGTKPF KEVFDLFLSQ LESDIPAISR CGLDLRIFSR FLLSRAMPMC
DDIVLQQAMI DTKNLSEIFP TDVSHYVDIV ENIAEDLLGY HIWNSFQLGR NLLTSRGWDL
FVNSFNKLSH MVAFQLLTSN SDRHREQIAR LYLDVADKLV KKNEFHFSHA IFSAFSKSSI
FRLKQFDAFL SQDAVYIRLN ELFEISKNFK NYRERIKETG GLPYWGLLSN DFIHLAELEV
NFNYYLFEGK TYSIVHDTQN KFIGTPLHFY TNIVTSILQT NIDEELLNSL SCEILPRTLY
LNDNLLVEEL IKNLQCRERH KLGLAIYDSE LKLASGLAAF DSIYAYVCQQ LADKIFSYES
CKNIMSLAVN LIQDDALKIN MLPYLLGLMD INSVPPSPVT LDIGASSESS AKLLSREISQ
VKRRKKEELA SLSHDRFSLT LDAVLTPRII FSRTNTVYQD NDKSDDVVNS GNLHSAQAIA
SDISNEIRLR NLRREKM
//
