ID A0A0R0BJ08_9GAMM Unreviewed; 221 AA.
AC A0A0R0BJ08; A0A7W3V0B5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Thymidylate kinase {ECO:0000256|ARBA:ARBA00017144, ECO:0000256|HAMAP-Rule:MF_00165};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980, ECO:0000256|HAMAP-Rule:MF_00165};
DE AltName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00029962, ECO:0000256|HAMAP-Rule:MF_00165};
GN Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN ORFNames=ABB25_09910 {ECO:0000313|EMBL:KRG57205.1}, H4O09_08640
GN {ECO:0000313|EMBL:MBB1117115.1};
OS Stenotrophomonas koreensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Stenotrophomonas.
OX NCBI_TaxID=266128 {ECO:0000313|EMBL:KRG57205.1, ECO:0000313|Proteomes:UP000051254};
RN [1] {ECO:0000313|EMBL:KRG57205.1, ECO:0000313|Proteomes:UP000051254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17805 {ECO:0000313|EMBL:KRG57205.1,
RC ECO:0000313|Proteomes:UP000051254};
RA Patil P.P., Midha S., Patil P.B.;
RT "Genome sequencing and analysis of members of genus Stenotrophomonas.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBB1117115.1, ECO:0000313|Proteomes:UP000550609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W1S232 {ECO:0000313|EMBL:MBB1117115.1,
RC ECO:0000313|Proteomes:UP000550609};
RA Deng Y.;
RT "Stenotrophomonas sp. W1S232.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-Rule:MF_00165}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001008, ECO:0000256|HAMAP-
CC Rule:MF_00165};
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776, ECO:0000256|HAMAP-Rule:MF_00165}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRG57205.1}.
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DR EMBL; LDJH01000016; KRG57205.1; -; Genomic_DNA.
DR EMBL; JACIUV010000003; MBB1117115.1; -; Genomic_DNA.
DR RefSeq; WP_057666336.1; NZ_LDJH01000016.1.
DR AlphaFoldDB; A0A0R0BJ08; -.
DR STRING; 266128.ABB25_09910; -.
DR PATRIC; fig|266128.3.peg.851; -.
DR OrthoDB; 9774907at2; -.
DR Proteomes; UP000051254; Unassembled WGS sequence.
DR Proteomes; UP000550609; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF4; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00165};
KW Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000313|EMBL:KRG57205.1};
KW Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00165}; Reference proteome {ECO:0000313|Proteomes:UP000051254};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW ECO:0000313|EMBL:MBB1117115.1}.
FT DOMAIN 14..207
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
FT BINDING 16..23
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00165"
SQ SEQUENCE 221 AA; 24053 MW; 6186C4C16E9DD482 CRC64;
MNDVLPRRAH LITLEGGEGA GKSTALATVR DCLQAAGCTL VVSREPGGTP LAEQLRAMVL
HSSRQDDADE RLHPSAELLM VFAARAQHVA EVINPALQRG DWVLCDRFTD SSFAYQGGGR
GLPVDWIADL ERRVVGFVPG LTLWLDVPVA LGRSRVQGRG GVPDAIEREH DAFFERVHAG
FAARVAADPQ RFVRIDASVP LEQMVAEVTR AVNAYLAQVR R
//