ID A0A0R0D4B9_9GAMM Unreviewed; 1154 AA.
AC A0A0R0D4B9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=ABB28_03610 {ECO:0000313|EMBL:KRG76347.1};
OS Stenotrophomonas chelatiphaga.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Stenotrophomonas.
OX NCBI_TaxID=517011 {ECO:0000313|EMBL:KRG76347.1, ECO:0000313|Proteomes:UP000051386};
RN [1] {ECO:0000313|EMBL:KRG76347.1, ECO:0000313|Proteomes:UP000051386}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21508 {ECO:0000313|EMBL:KRG76347.1,
RC ECO:0000313|Proteomes:UP000051386};
RA Patil P.P., Midha S., Patil P.B.;
RT "Genome sequencing and analysis of members of genus Stenotrophomonas.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRG76347.1}.
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DR EMBL; LDJK01000009; KRG76347.1; -; Genomic_DNA.
DR RefSeq; WP_057507311.1; NZ_LDJK01000009.1.
DR AlphaFoldDB; A0A0R0D4B9; -.
DR PATRIC; fig|517011.3.peg.3474; -.
DR Proteomes; UP000051386; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000051386}.
FT DOMAIN 623..784
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 797..959
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1154 AA; 127954 MW; 25967837DF91C2BC CRC64;
MSRSPYPLPP LPRPGQLRAW WRAPSSPTAL AWYLARAAQA HDGPVLVVAP DNHGANQIES
DLRTLLGDDP SLPVVAFPDW ETLPYDRFSP HPDIISQRLS ALHRLPGLKR GLVVVPVQTL
MQQLAPKQYV IGGSFDLEVG QRLDLDAEKR RLESAGYRNV PQVMDPGDFA VRGGLLDVYP
MGASEPLRVE LLDQDIDTIR AFDPETQRSL EKVQAVHMLP GREVPMDDAS ISRVMDALRE
RFDVDTRRSS LYQDLKSRLA PAGIEYYLPL FFDHTATLFD YFSADVLPVM AAGVGEAAAA
FWAQTGQRYE QRRHDVERPL LPPGQLYLSP ELLRERLNDL PRVEVWPPGH ARIEQAHALG
DTALPPLPVA ARDAAAGQAL ATFIEQYPGR VLIAADTAGR REALLEVLQA ASLRPPVVAD
LPTFLAGSER FAITVAPLED GFALDDPRIA VLTERQLFPE RAAHQRRSRR AGREPEAIIR
DLGELTEGAP IVHEDHGVGR YRGLIAMDVG GMPGEFLEIE YAKGDRLYVP VAQLHLISRY
SGASAETAPL HSLGGEQWTK AKRKAAEKVR DVAAELLEIQ ARRRARAGLA LDVDRAMYEP
FAAGFPFEET QDQLAAIDAT LRDLASSQPM DRVVCGDVGF GKTEVAVRAA FAAASAGKQV
AVLVPTTLLA EQHYRNFRDR FADYPMKVEV LSRFKSTKEI KAELEKVADG TIDVIIGTHR
LLQPDVKFKD LGLVVVDEEQ RFGVRQKEAL KAMRANVHLL TLTATPIPRT LNMAMAGLRD
LSIIATPPPN RLAVQTFISQ WDDALLREAF QRELARGGQL YFLHNDVESI GRMQRELSEL
VPEARIGIAH GQMPERELER VMLEFQKQRF NVLLSTTIIE SGIDIPNANT IIINRADRFG
LAQLHQLRGR VGRSHHRAYA YLVVPDRRSI TPDAEKRLEA IASMDELGAG FTLATHDLEI
RGAGELLGED QSGQMAEVGF SLYTELLERA VRSIRLGKLP DLDAGEEARG AEVELHVPSL
IPNDYLPDVH TRLTLYKRIS SARDSASLRE LQVEMIDRFG LLPDAAKHLF AIAELKLQAN
ELGIRKVDLG EAGGRIVFEA KPNIDPMSVI QLIQKQSNLY SMDGPDKLRI KHPLPLPEDR
FNAARALLTT LAPG
//
