ID A0A0R0E2D4_9GAMM Unreviewed; 337 AA.
AC A0A0R0E2D4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:KRG84775.1};
GN ORFNames=ABB34_08425 {ECO:0000313|EMBL:KRG84775.1};
OS Stenotrophomonas daejeonensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Stenotrophomonas.
OX NCBI_TaxID=659018 {ECO:0000313|EMBL:KRG84775.1, ECO:0000313|Proteomes:UP000050940};
RN [1] {ECO:0000313|EMBL:KRG84775.1, ECO:0000313|Proteomes:UP000050940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 16244 {ECO:0000313|EMBL:KRG84775.1,
RC ECO:0000313|Proteomes:UP000050940};
RA Patil P.P., Midha S., Patil P.B.;
RT "Genome sequencing and analysis of members of genus Stenotrophomonas.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRG84775.1}.
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DR EMBL; LDJP01000048; KRG84775.1; -; Genomic_DNA.
DR RefSeq; WP_057640868.1; NZ_LDJP01000048.1.
DR AlphaFoldDB; A0A0R0E2D4; -.
DR STRING; 659018.ABB34_08425; -.
DR PATRIC; fig|659018.3.peg.1632; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000050940; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000050940}.
FT DOMAIN 17..313
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 112..291
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 337 AA; 35239 MW; 9E3DFFBA18AADCEF CRC64;
MAERRPRVWV SQPLFDDTVA QLAAYCDVVA TPAVTAYDSA ALAAHLSGAD GALVTLNERI
GAAEIADAPA LKVVANIGVG YNNLDLAALS AAGIVATNTP DVLTETTADL GFALLMAAAR
RIVESDRWLR EGNWGQWSFT TMLGADLHGS TLGILGMGRI GQAIARRGHH GFGMKVLYHN
RSRLPQETER DVGARYAGFD ELLSSADHLL LVLPYTAQNH HVIDAAALAK MKPTATLVNI
ARGGIVDELA LAGALAGGRL ASAALDVYEN EPAVRPELLA LRNIVLTPHI GSASLATRRA
MVQVAVDNLL AGLGIGADAG RPANALNAIA GGKTEKR
//
