ID A0A0R0LFN5_9PROT Unreviewed; 853 AA.
AC A0A0R0LFN5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:KRH78026.1};
GN ORFNames=FERRO_19810 {ECO:0000313|EMBL:KRH78026.1};
OS Ferrovum sp. JA12.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Ferrovales; Ferrovaceae;
OC Ferrovum.
OX NCBI_TaxID=1356299 {ECO:0000313|EMBL:KRH78026.1, ECO:0000313|Proteomes:UP000050960};
RN [1] {ECO:0000313|EMBL:KRH78026.1, ECO:0000313|Proteomes:UP000050960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA12 {ECO:0000313|EMBL:KRH78026.1,
RC ECO:0000313|Proteomes:UP000050960};
RA Poehlein A., Ullrich S.R., Tischler J.S., Schloemann M., Muehling M.,
RA Daniel R.;
RT "Genome sequence of the acidophilic iron oxidising Ferrovum strain JA12.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRH78026.1}.
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DR EMBL; LJWX01000003; KRH78026.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R0LFN5; -.
DR STRING; 1356299.FERRO_19810; -.
DR PATRIC; fig|1356299.4.peg.1988; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000050960; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 687..703
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 853 AA; 95399 MW; 6FB2FB01F76D4694 CRC64;
MNSPQHTPMM TQYLAIKAQH TEYLLFYRMG DFYELFFHDA EKASRLLDIT LTRRGQSAGQ
PIPMAGVPVH AAEQYLAKLV RLGESVAICE QVGDPATSKG PVAREVVKII TPGTLTESSL
LEDDKDTLLA SVWINTAQMG LAVINVLTGV LTLTEHHISD LASTLERIAP AEILLPEGVT
LPFTHHSHYT VTRPHFHFDR ERGQKMLCEQ LGVFDLNGFG AASLSLAHGA ACALIYYIEH
THKHTQHIIH SLRVENATDF VQMDPNTRRH LEITETQSGH HSPSLLSVLD VCKNPMGRRL
LRHWLHHPLR DLSQITARQA WIEVWVAPEH QEALQDLRKT LQHIADIERI LGRLGLKQAR
PRDLSALRES LSLLPTVSAL LGQVNRQLFS SFISQIQALP SAPLNLLQRA IKDEPAVSLK
DGGVIAAGYD SDLDELRLLQ QDQGQFLIDL ELAEKERTNI PTLRVEYNRV HGFFIEVSRS
YSDRVPVHYQ RRQTLKNSER YTTEHLSAFE EKILHANERA LSREKYLFDQ LVDQLTEYLT
PLKTLASLVA TSDVMTTLAH QAIHLNLVKP ILTEEQGIHI TQGRHLVVEQ QVERFIANSV
ALHHQRRLLM ITGPNMGGKS TYMRQCALIT LLAHVGSFVP ASHATLGLVD QIFTRIGAND
DLASGRSTFL VEMSEAATIL NRATAKSLVL IDEIGRGTST YDGLSLAHAI ALDLAQRIGC
LTLFATHYFE LTELAGEVDG VVNVHFDALE HGEHIVFLHS LEEGPASQSY GLQVARLAGV
PRPVIELART KLKALESSRP LSLTQEPPGP MRQQELFANS PIIEELKGLD PNQLSARQAL
DLIYRWREDI DLY
//
