ID A0A0R1R801_9LACO Unreviewed; 707 AA.
AC A0A0R1R801;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Cell division protein penicillin-binding protein 2 {ECO:0000313|EMBL:KRL53231.1};
GN ORFNames=FD01_GL001336 {ECO:0000313|EMBL:KRL53231.1};
OS Lacticaseibacillus manihotivorans DSM 13343 = JCM 12514.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=1423769 {ECO:0000313|EMBL:KRL53231.1, ECO:0000313|Proteomes:UP000051790};
RN [1] {ECO:0000313|EMBL:KRL53231.1, ECO:0000313|Proteomes:UP000051790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13343 {ECO:0000313|EMBL:KRL53231.1,
RC ECO:0000313|Proteomes:UP000051790};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRL53231.1}.
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DR EMBL; AZEU01000018; KRL53231.1; -; Genomic_DNA.
DR RefSeq; WP_056962321.1; NZ_AZEU01000018.1.
DR AlphaFoldDB; A0A0R1R801; -.
DR PATRIC; fig|1423769.4.peg.1437; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000051790; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KRL53231.1};
KW Cell division {ECO:0000313|EMBL:KRL53231.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000051790}.
FT DOMAIN 65..300
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 347..681
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 707 AA; 76473 MW; 58FF817E8E744BCD CRC64;
MKYIRTPKPK RAKSHIPFRL NLLFFFVFLL LAALVGQLAY LQILNGGKFA AEVNRTDQTT
VTGAVPRGLI YDSQGRVLVE NKANNAITFT KSVNTTSQSM YDTANRLVRY ITVDHDNLQK
RDYADYVLAD SKAAKAVVKE LPKSQQSETD ATKLYKYEVA YVQKHLPDFS TKQKEAIALY
KIMNGATQLT TVYLKNSGVT TQESAAVGEN LTAMSGVNLG TDWERAYPNG DSMTAIIGTV
SSTKSGLPSD GLQSYLAQGY ARNDRVGISY LEKGYESILK GAKSRTQVEL GNNNNIVKQV
QTFKGQQGSN LNLTIDSAYQ NKVQSIVKSV FNQALSNGAA AHSDGAFAVA MNPQTGAILA
LAGESHNVKT GKVTEDALGA INRSFAMGSA VKPAMVLGAL QDGVITVNNN TQSDDPIYLP
STPVKKSVYP VGTFSSMNAT TALEVSSNIY MMRLAMKEGN AKYVPKTSMV MDNNIFTKMR
RYFSEFGLGQ TTGVDLPGEV KGQTGSTTLN GSLAVGSALD LSYGNYDTYT LMQMAQYVST
VANNGYRMKP YIVKSISQTL PDGSNGATIS TTSPQVQLKV PNTQAQIDLV KQGMWEVVHG
TNGWTTATML NTLNPGVAGK TGTAQTFTRS DPTNTNSELL ETTTLSFVGF APAKNPQIAI
AVVVPNLSNE DVNYNELIAK QMFADYYSMN DVKKDSSYSA HQTSING
//
