ID A0A0R2ESE5_9LACO Unreviewed; 873 AA.
AC A0A0R2ESE5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN ORFNames=FD14_GL001742 {ECO:0000313|EMBL:KRN19330.1};
OS Secundilactobacillus similis DSM 23365 = JCM 2765.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Secundilactobacillus.
OX NCBI_TaxID=1423804 {ECO:0000313|EMBL:KRN19330.1, ECO:0000313|Proteomes:UP000051442};
RN [1] {ECO:0000313|EMBL:KRN19330.1, ECO:0000313|Proteomes:UP000051442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23365 {ECO:0000313|EMBL:KRN19330.1,
RC ECO:0000313|Proteomes:UP000051442};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN19330.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYZM01000138; KRN19330.1; -; Genomic_DNA.
DR RefSeq; WP_054737192.1; NZ_BBAD01000079.1.
DR AlphaFoldDB; A0A0R2ESE5; -.
DR STRING; 1423804.FD14_GL001742; -.
DR PATRIC; fig|1423804.4.peg.1885; -.
DR OrthoDB; 9815791at2; -.
DR Proteomes; UP000051442; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000051442}.
FT DOMAIN 11..284
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 471..853
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 873 AA; 95359 MW; C0FAE81C766EA284 CRC64;
MLKETNSKPT TKTTKKPATI AETIDQLVEN AHDALCAMDD FTQEKVDNIV HQMAMAGLDH
HMELAKLAYE ETGRGVIEDK AIKNMFATEE IWNSIKNDKT VGIINDDHER QLITVAEPLG
IIAGVTPVTN PTSTTLFKSL IAVKTRNPII FAFHPQAQKS SAAAAKVVRD AAIAAGAPEG
VIQWIETPSL EATQTLMNHE RVASVLATGG PGMVKAAYST GKPALGVGPG NGPAYIEKTA
NIKRAVNDIV LSKTFDNGMV CASENSAVID ADIYDDVKKE MKARKVFFIK KADHKALADA
MFDQKRGGVK GPIPGMSAVA IAKLAGIEVP EDTKVLAAEI KEVGPKDWLS AEKLCPVISI
YKAADHAEGF ALCDQLLHFG GLGHTASIHT LDDDLATEFG IQMKASRVLV NTPSAIGGIG
NMYNEMVPSL TLGTGSWGKN SVSHNVSSFD LLNIKTIAKR RNNMQWIKLP RVYFEKTSVR
YLGSMPGIKK VFIVADAVMI ELGYVDKVLG ELKRRPDGIE YQLFSITETD PTTDTVEKGT
QQMNNFQPDT IIALGGGSPM DAAKGMWLFY EHPDASFFGA KQKFLDIRKR TYKLEKPNKA
QFVAIPTTSG TGSEVTPFAV ITDAKTHVKY PLADYALTPD VAIVDSQFIE TLPKRTISYA
GLDVLTHAIE SYVSNMASDY TRPWSLQAIK LVFDNLTASY NGDLQARAEM HNAATIAGMA
FANAFLGVNH SIAHKLGGEF GLPHGLAIAI TLPHVIRYNF KEPRKLTMWP KYEYFRADED
YAQIARYIGL QGKTNEELKE ALVQKVIELA HSVDVTLSLK ANGVDKKHLE DTVDKLAELA
YEDQCTTANP KEPLIGELRQ IMLDEYDGKG VED
//
