ID A0A0R2FZ78_9LACO Unreviewed; 1251 AA.
AC A0A0R2FZ78;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Transport protein {ECO:0000313|EMBL:KRN33779.1};
GN ORFNames=IV38_GL000579 {ECO:0000313|EMBL:KRN29692.1}, IV40_GL000089
GN {ECO:0000313|EMBL:KRN33779.1};
OS Lactobacillus selangorensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=81857 {ECO:0000313|EMBL:KRN33779.1, ECO:0000313|Proteomes:UP000051645};
RN [1] {ECO:0000313|Proteomes:UP000051645, ECO:0000313|Proteomes:UP000051751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-66 {ECO:0000313|EMBL:KRN29692.1,
RC ECO:0000313|Proteomes:UP000051751}, and DSM 13344
RC {ECO:0000313|EMBL:KRN33779.1, ECO:0000313|Proteomes:UP000051645};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN33779.1}.
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DR EMBL; JQAT01000001; KRN29692.1; -; Genomic_DNA.
DR EMBL; JQAZ01000001; KRN33779.1; -; Genomic_DNA.
DR RefSeq; WP_057768282.1; NZ_JQAZ01000001.1.
DR AlphaFoldDB; A0A0R2FZ78; -.
DR STRING; 81857.IV38_GL000579; -.
DR PATRIC; fig|81857.3.peg.584; -.
DR OrthoDB; 9782006at2; -.
DR Proteomes; UP000051645; Unassembled WGS sequence.
DR Proteomes; UP000051751; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 2.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR023908; xxxLxxG_rpt.
DR NCBIfam; TIGR03057; xxxLxxG_by_4; 7.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051645};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1072..1091
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1134..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1174..1194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1200..1227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1103..1229
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1251 AA; 130735 MW; 363B618B907CC154 CRC64;
MRNFRKNHIG SAVIWLVVVL IAIFSLPNLT QLVSEKGQTK IPSSSQSQVA NMIQKNWGHG
QKNTTQVVAV FNNGDHKLTD SQKDQIDDAV QTLEDNKAHF GIKDVLDPSS NKEAKKQLVS
KDGTTEIVQL MVAKSHGSYT KIDSQLTKAI KTPGLKTYVT GADILNDDFS KATEAGIQKT
EVIAAVFIFI VLIIVFRSPV VPLISLLTVG VTYITSLSIV ANLVKYANFP FSNFTQVFMV
VVLFGIGTDY NILLYDQFKE ELSHGKDNWE ATRSAVKIAG RKILYSGLSL LIGFSALFLA
QFSIYRSASG VAVGVAVLLI VLLTLNPFFM ATLGPTMFWP TKNFNGGSRS KMWQWLSAHS
VLHPIISLAI VLIATLPFIL TYHNNLNYDN LAELSDSLPA KQGVQVVQKH FSKGTAEPST
LYIQADHKLN NEEALKLIDM VTKTAQAEPG VKTVASATQP GGSKVSALYA NNQLSTVTSG
MNTANKGLNK IGKGLNSADK KLSGTDMQSG LSQVKQLSDG ASTLANGAVA LNSGITELDN
GSEQISSNLS VLNDGVQQYT AGVGRLNSGA SALNNGIQSY TAGASQLGSG ASQLSSGVQT
YTSGVSSLNN GLQTLANKNS ELESGASQLA SGVTSLQSGS QQLSNGLSQM QSQLNGSTSA
AQLEQLNTGL GQINSAISTL ANTQSTLSTS LTSVGDNITS AGASTQKTAD DLKQIQAALA
ANPQLAQSNP ALAAAVSDIA TNTKNTGDQL NTAGTTLKGI SGSSSSLTSD QISQMQTALT
GAQSAVTALE SVQNALNNQG LVSGSQQLTA GLNQLTAGTN QVTSGLQAYT SGVASAASGA
SQLSANSSTL NSGAAQLASG TSELNANSSA LNSGASQLAS GTSELSANSA TLNSGSAQLA
AASQQMTTGL GTLSSQAPTF VSGLMQVSNG TQTMYTTLSG LTGEMGQLQT GLNSAATGVT
KVAKGTKSAN SYLKGLQNSS AADEFYIPKS VLKGDTFKQS LNTYMSSDMK ATKMTIVLDS
DPASETAMNR VTNMQKVIKN NLKGTSLENA TVAIGGQTST LADTKSIASQ DFIRTAAIML
VGIALALMVV TRSLLQPFYI LGTLLLAYMT SLGLTKLFST AFLGQSMLTW NTPFFGFIML
IALGVDYSIF LMMKYRELAG TGTPGQRIVQ ASGIIGAVVL SAALILSGTF AALMPSGVLT
LIQVALVVII GLIILVIILP IVLPALIKLT YPAKPDKNDD TKTTRQERNQ D
//
