ID A0A0R2H890_WEIVI Unreviewed; 476 AA.
AC A0A0R2H890;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:KRN46295.1};
GN ORFNames=IV50_GL000563 {ECO:0000313|EMBL:KRN46295.1};
OS Weissella viridescens (Lactobacillus viridescens).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae; Weissella.
OX NCBI_TaxID=1629 {ECO:0000313|EMBL:KRN46295.1, ECO:0000313|Proteomes:UP000051992};
RN [1] {ECO:0000313|EMBL:KRN46295.1, ECO:0000313|Proteomes:UP000051992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20410 {ECO:0000313|EMBL:KRN46295.1,
RC ECO:0000313|Proteomes:UP000051992};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN46295.1}.
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DR EMBL; JQBM01000002; KRN46295.1; -; Genomic_DNA.
DR RefSeq; WP_057744756.1; NZ_JQBM01000002.1.
DR AlphaFoldDB; A0A0R2H890; -.
DR PATRIC; fig|1629.5.peg.567; -.
DR OrthoDB; 9804590at2; -.
DR Proteomes; UP000051992; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR NCBIfam; TIGR00479; rumA; 1.
DR PANTHER; PTHR11061:SF45; -; 1.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR Pfam; PF01938; TRAM; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01024,
KW ECO:0000313|EMBL:KRN46295.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051992};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01024,
KW ECO:0000313|EMBL:KRN46295.1}.
FT ACT_SITE 434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 434
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 309
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 338
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 359
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 407
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 476 AA; 53833 MW; 09C7969788BDF503 CRC64;
MPDYKKKTYN QNQRNAKSNQ KQNQDVQVEV GDKLLITIKR LGINGEGIGY YKRKITFIPN
ALPGEVVDVV VTAVNPKFIE ARIRKFKQKS PDRIEPLDNQ EVGGTELGHL RYEKQLEFKQ
DVIRQALEKY RPRGYEDYDL RPTIGMDDPT GYRNKAQFPI RKQGDHLAVG MYKPNSHELV
DLPEISTQHP ATLKVVRTVR DILEELEVPI YDEKQNSGIV KTLIARVSES TGDVQLTLVT
NSPKLPKARQ IIERINADLP EVVSIDQNIN KGKTSLVWGE ETKHLWGTDY ITETINGKQF
MLSPRAFLQL NPKQTERLYQ EAIKALDLTH ADKLVDAYSG VGTIGLSLAD QAGEVRGMDT
VADAVYDANE NAEANEIENA DYFVGEAEVL IPEWADQGWV ADAMVVDPPR TGLGEALRDT
ILDTEPEKLV YISCNASTLA RDLEDLTEVY DVDYIQSIDM FPQTARWEGI VKFTRR
//
