ID A0A0R2I3W1_CARDV Unreviewed; 905 AA.
AC A0A0R2I3W1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=IV74_GL000491 {ECO:0000313|EMBL:KRN56844.1};
OS Carnobacterium divergens DSM 20623.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Carnobacterium.
OX NCBI_TaxID=1449336 {ECO:0000313|EMBL:KRN56844.1, ECO:0000313|Proteomes:UP000051658};
RN [1] {ECO:0000313|EMBL:KRN56844.1, ECO:0000313|Proteomes:UP000051658}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20623 {ECO:0000313|EMBL:KRN56844.1,
RC ECO:0000313|Proteomes:UP000051658};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRN56844.1}.
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DR EMBL; JQBS01000017; KRN56844.1; -; Genomic_DNA.
DR RefSeq; WP_034572322.1; NZ_JQLO01000001.1.
DR AlphaFoldDB; A0A0R2I3W1; -.
DR PATRIC; fig|1449336.4.peg.504; -.
DR eggNOG; COG2205; Bacteria.
DR Proteomes; UP000051658; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000051658};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 678..899
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 905 AA; 102319 MW; 6730DDAD0CCDC34D CRC64;
MDEENRPNPD QLLLKYGAKS SNQRGKLKVF FGYAAGVGKT YGMLRAAIEQ SEAGKNVLVG
YVEPHARPET IALLENLTTL PTKTIDYRGL SLEEFDLDSA LLAKPELILV DELAHTNVEG
SRNRKRYQDI DELLNAGIDV YTTMNVQHLE SLNDIVEEIT NIHVNETVPD HFFDEAFIKL
IDVEPEELVH RLKEGKIYQP HNAKKAMNHF FTLENLKLLR EIAIRKAADY IGMENRPDQL
LNNKRVQSKL LTYIDDTSKV GAEKCIRWTA RLAVAFRAEW VVLFVENDES DGKSTNEQVM
KNFELAETLG AETVTLNAHD KVETIIQYAK LTGVTDIIIG KKRRGQNFRK LFKTELEDQL
VQELNNVEIH MIPFAEKADS AKPREIKNSW KPKLFSTSNF LKTILLLVVA TLCSEVVTYL
GIGEQNVIVV YLLFVLIIAR ATYGYSYGVF ASILSVLLFN WFFVEPLYSL TVYKPGYPIT
LLIMLAVALF TSNMMIRVKS QARDSIEKEH RMEVIYDLNK DLLRVKSING IVAITNRYLA
QTLERSVIFY TEKPEQNQAY QVEVYNGNQE AQASLVSDSE IAVANWVFNN RKEAGFGSNT
LMGASTYYFP LLSQGDTVAV IGVYCLNERP LTHENLNFLK LISTQISLAL ERQHLANEQQ
EILLESEKEK MRGNLLRAIS HDLRTPLTGI LGASSAIIEN KDKFTEPLKL QLLTDIKEDS
EWLIRMVENL LSVTRIDEGT MKVNKVPEAV EEIAATAVRR IRKRFPQQEI QITVPEELLL
VPMDGKLIEQ VLINLMENAI RHSGKITPIM VNVLRKDKDV VFEVRDQGIG IKKERLNNLF
NPFDGSKVSQ GNAPIDAKRG LGIGLSICKT IIAAHNGTIS GENNETDGAV FRFTLPIEPN
EEENG
//
