ID A0A0R2LUW6_9LACO Unreviewed; 750 AA.
AC A0A0R2LUW6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Metallo-beta-lactamase superfamily hydrolase {ECO:0000313|EMBL:KRO04935.1};
GN ORFNames=IV54_GL000659 {ECO:0000313|EMBL:KRO04935.1};
OS Levilactobacillus paucivorans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Levilactobacillus.
OX NCBI_TaxID=616990 {ECO:0000313|EMBL:KRO04935.1, ECO:0000313|Proteomes:UP000051906};
RN [1] {ECO:0000313|EMBL:KRO04935.1, ECO:0000313|Proteomes:UP000051906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22467 {ECO:0000313|EMBL:KRO04935.1,
RC ECO:0000313|Proteomes:UP000051906};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Nat. Commun. 6:8322-8322(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRO04935.1}.
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DR EMBL; JQCA01000020; KRO04935.1; -; Genomic_DNA.
DR RefSeq; WP_057877531.1; NZ_JQCA01000020.1.
DR AlphaFoldDB; A0A0R2LUW6; -.
DR STRING; 616990.IV54_GL000659; -.
DR PATRIC; fig|616990.3.peg.704; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000051906; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:KRO04935.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 497..701
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 750 AA; 83030 MW; 7C984EC5F33D8592 CRC64;
MGGRWLFVAL PLAALSVALS GHPWAGLALV VVAWGRVLTL RSARIVVITG LVFVVIGGVW
WGRQRQLAGR LVSAFTESPA SLTVRFQPDA LSIRGATYSF VGRAAATGER LILHGRIGSA
EELHRLQTVD HAQSWHIQGT QSGILPATNF NQFDGATYWS RRGIVKQVRI AQVTPLMATT
GPLTWWSDWW HGLRARLIRA CQRLPGALKV YALGLLPGYR ALEATQELEG MQRLGLLHLF
SISGLHVSLV LLVVEWLCVH CRLPRNLWER GMIIGLPGYF ILAGGGGSIL RASLMRGLQL
SGRQLGLRVT GLDAWSLTLI AALMGNAGLL FELGSQLSFG LSLVLILLEQ ESFAWRQVGL
ALVSLPSLLN GLFQWHLLTL LANWLVVPLF PVLLLPLTVV GTAIFPWVPE VSRGCATLLG
WFDQTMTWLG TLPGNLVFGK PWWWVCWLWI WLAVGVFSRP VGQRRKLLRL LAMSYGLMYG
AIHFPWHGEV TYFDVGQGDS ILIRERFNRH VSLIDTGGHL GFQQPHWVPK IPVTYAADRT
SVTYLRSHGV TTIDDLYLTH HDADHIGDLP AILKAFRVKR VLVPAGMEKE PAWQHLLANR
QATTALMPIK TTSDLPLTVR HPFEADPAEN ANSLALQGQY GGLNFLFMGD LDQAGEQKML
EVDPHLRTDV LKLGHHGSKT ASGVAFLNQV RPRWGIISAG RHNRYGHPNP ETLARLRADQ
IPAVSTQTSG MIRYVFAGQH GEWQTKLKGD
//
